World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
71
Citations
18483
World Ranking
19992
National Ranking
9957

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David J. Tweardy is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on the field of medicine, with significant contributions in oncology, pulmonary and respiratory medicine, immunology, molecular biology, and pathology and forensic medicine.

The scientist's work covers several main topics, including:

  • Cytokine Signaling Pathways and Interactions
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • Advanced Breast Cancer Therapies
  • Cancer Mechanisms and Therapy
  • Cancer-related Molecular Pathways
  • Lung Cancer Research Studies

Frequently publishing in prominent venues, their work often appears in:

  • Cancer Research
  • Biochemical Pharmacology
  • International Journal of Molecular Sciences
  • Pharmacological Reviews
  • Nature Communications

Their recent scientific papers include:

  • "Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution" (2020, Pharmacological Reviews)
  • "Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy" (2020, Nature Communications)
  • "Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40" (2020, American Journal of Physiology-Endocrinology and Metabolism)
  • "Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease" (2022, JHEP Reports)
  • "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" (2021, Biochemical Pharmacology)

David J. Tweardy has collaborated regularly with other researchers, including:

  • Moses M. Kasembeli
  • T. Kris Eckols
  • Uddalak Bharadwaj
  • Prema Robinson
  • Michael J. Clowers

The scientist has been recognized with several awards during their career, such as becoming a Fellow of the American Association for the Advancement of Science (AAAS) in 2016 and membership in the Association of American Physicians.

Best Publications

  • Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

    Jennifer Rubin Grandis;Mona F. Melhem;William E. Gooding;Roger Day

  • Elevated Levels of Transforming Growth Factor α and Epidermal Growth Factor Receptor Messenger RNA Are Early Markers of Carcinogenesis in Head and Neck Cancer

    Jennifer Rubin Grandis;David J. Tweardy

  • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

    Jennifer Rubin Grandis;Stephanie D. Drenning;Arup Chakraborty;Min Yu Zhou

  • Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

    Christian Hierholzer;Brian G Harbrecht;John M. Menezes;John Kane

  • Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients.

    R. A. Salata;M. M. Lederman;D. M. Shlaes;M. R. Jacobs

  • Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms

    Carlo M. Croce;Masaharu Isobe;Antonio Palumbo;Jennifer Puck

  • Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.

    Jörg C. Kalff;Andreas Türler;Nicolas T. Schwarz;Wolfgang H. Schraut

  • Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

    Wei Lou;Zuyao Ni;Kevin Dyer;David J. Tweardy

  • Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

    Michele S. Redell;Marcos J. Ruiz;Todd A. Alonzo;Todd A. Alonzo;Robert B. Gerbing

  • Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

    Liping Zhang;Jenny Pan;Yanjun Dong;Yanjun Dong;David J. Tweardy

  • Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

    Uddalak Bharadwaj;Moses M. Kasembeli;Prema Robinson;David J. Tweardy

  • G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis

    Naijie Jing;Yidong Li;Weijun Xiong;Wei Sha

  • Identification and Characterization of Signal Transducer and Activator of Transcription 3 Recruitment Sites within the Epidermal Growth Factor Receptor

    Huang Shao;Haiyun Y. Cheng;Richard G. Cook;David J. Tweardy

  • Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock.

    Zhi Hong Meng;Kevin Dyer;Timothy R. Billiar;David J. Tweardy

  • Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma.

    Jennifer Rubin Grandis;David J. Tweardy;Mona F. Melhem;Mona F. Melhem

  • STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation

    Mesias Pedroza;Thuy T. Le;Katherine Lewis;Harry Karmouty-Quintana

  • Single Nucleotide Polymorphisms in Genes for 2′-5′-Oligoadenylate Synthetase and RNase L in Patients Hospitalized with West Nile Virus Infection

    Imtiaz Yakub;Kristy M. Lillibridge;Ana Moran;Omar Y. Gonzalez

  • Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from a Pol III promoter

    Yukai He;Jennifer R. Grandis;Leaf Huang

  • Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

    U. Bharadwaj;T. K. Eckols;M. Kolosov;M. M. Kasembeli

  • Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells.

    J. Rubin Grandis;A. Chakraborty;M. F. Melhem;Q. Zeng

Frequent Co-Authors

Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Jennifer R. Grandis
Jennifer R. Grandis University of California, San Francisco
Penelope A. Morel
Penelope A. Morel University of Pittsburgh
Richard L. Simmons
Richard L. Simmons University of Pittsburgh
Anthony J. Bauer
Anthony J. Bauer Liberty University
Joel V. Weinstock
Joel V. Weinstock Tufts Medical Center
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Wah Chiu
Wah Chiu Stanford University
Susan G. Hilsenbeck
Susan G. Hilsenbeck Baylor College of Medicine
Kelly K. Hunt
Kelly K. Hunt The University of Texas MD Anderson Cancer Center

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