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D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
9198
World Ranking
18656
National Ranking
1277

Overview

Andreas Klos is affiliated with Hannover Medical School in Germany and has contributed extensively to research in immunology and microbiology, with additional focus on medicine. Their work spans multiple subfields including immunology, epidemiology, microbiology, hematology, and parasitology.

The scientist's research topics cover a range of areas such as reproductive tract infections, the complement system in diseases, urinary tract infections management, immune response and inflammation, blood coagulation and thrombosis mechanisms, vector-borne infectious diseases, and cervical cancer and HPV research.

Andreas Klos has published in several academic venues, with frequent contributions to:

  • Frontiers in Immunology
  • Vaccines
  • Thrombosis and Haemostasis
  • arXiv (Cornell University)
  • The Journal of Immunology

Recent notable papers include:

  • Complement and Chlamydia psittaci: Non-Myeloid-Derived C3 Predominantly Induces Protective Adaptive Immune Responses in Mouse Lung Infection (2021) in Frontiers in Immunology
  • Prophylactic Multi-Subunit Vaccine against Chlamydia trachomatis: In Vivo Evaluation in Mice (2021) in Vaccines
  • Complement and Chlamydia psittaci: Early Complement-Dependent Events Are Important for DC Migration and Protection During Mouse Lung Infection (2021) in Frontiers in Immunology
  • Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme (2024) in Frontiers in Immunology
  • Cardiac Repair after Myocardial Infarction is Controlled by a Complement C5a Receptor 1-Driven Signaling Cascade (2024) in Thrombosis and Haemostasis

Frequent collaborators in their research include:

  • Robert Laudeley
  • Martin Kohn
  • Christian Lanfermann
  • Claudia Rheinheimer
  • Silke Glage

Andreas Klos' research emphasizes the role of the complement system in immune responses, especially in infections and inflammatory conditions. Their work on Chlamydia species and immune mechanisms explores how complement components influence pulmonary and systemic infections. Other studies explore therapeutic approaches like alpha1-antitrypsin in sepsis and complement receptor signaling in cardiac repair following myocardial infarction.

Best Publications

  • The role of the anaphylatoxins in health and disease.

    Andreas Klos;Andrea J. Tenner;Kay-Ole Johswich;Rahasson R. Ager

  • Molecular Intercommunication between the Complement and Coagulation Systems

    Umme Amara;Michael A. Flierl;Daniel Rittirsch;Andreas Klos

  • Interaction between the coagulation and complement system.

    Umme Amara;Daniel Rittirsch;Michael Flierl;Uwe Bruckner

  • T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

    Giuseppina Arbore;Erin E. West;Rosanne Spolski;Avril A. B. Robertson

  • Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6.

    Oliver Selberg;Hartmut Hecker;Michael Martin;Andreas Klos

  • International Union of Basic and Clinical Pharmacology. LXXXVII. Complement Peptide C5a, C4a, and C3a Receptors

    Andreas Klos;Elisabeth Wende;Kathryn J. Wareham;Peter N. Monk

  • Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models

    Ames Rs;Lee D;Foley Jj;Jurewicz Aj

  • Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins.

    Silke F. Fischer;Juliane Vier;Susanne Kirschnek;Andreas Klos

  • Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells

    Torsten Crass;Ute Raffetseder;Ulrich Martin;Melanie Grove

  • Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury.

    T Heller;M Hennecke;U Baumann;J E Gessner

  • The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes

    Ulrich Martin;Daniel Bock;Lubomir Arseniev;Mark A. Tornetta

  • Circulating complement proteins in multiple trauma patients--correlation with injury severity, development of sepsis, and outcome.

    Friederike Hecke;Ulf Schmidt;Axel Kola;Wilfried Bautsch

  • The human complement fragment receptor, C5L2, is a recycling decoy receptor.

    Anne-Marie Scola;Kay-Ole Johswich;B. Paul Morgan;Andreas Klos

  • Cutting edge: guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma.

    Wilfried Bautsch;Heinz-Gerd Hoymann;Qiuwang Zhang;Ivo Meier-Wiedenbach

  • C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis

    Jeanne Godau;Tanja Heller;Heiko Hawlisch;Matthew Trappe

  • Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome.

    S Stöve;T Welte;T O Wagner;A Kola

  • C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.

    Magnus Otto;Heiko Hawlisch;Peter N. Monk;Melanie Müller

  • Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor

    Franziska Glatzer;Maria Gschwandtner;Maria Gschwandtner;Sarah Ehling;Kristine Rossbach

  • C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding

    A Klos;S Bank;C Gietz;W Bautsch

  • Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis.

    Heller T;Gessner Je;Schmidt Re;Klos A

Frequent Co-Authors

Jörg Köhl
Jörg Köhl University of Lübeck
Peter N. Monk
Peter N. Monk University of Sheffield
Ulrich Martin
Ulrich Martin Hannover Medical School
Hermann Haller
Hermann Haller Hannover Medical School
Trent M. Woodruff
Trent M. Woodruff University of Queensland
Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Claudia Kemper
Claudia Kemper National Institutes of Health
Henry M. Sarau
Henry M. Sarau GlaxoSmithKline (United Kingdom)
Michael Kracht
Michael Kracht University of Giessen
Rick A. Wetsel
Rick A. Wetsel The University of Texas Health Science Center at Houston

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