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Molecular Biology

D-Index
50
Citations
11218
World Ranking
2551
National Ranking
174

Overview

Walter Witke is affiliated with the University of Bonn in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with notable contributions to subfields including Molecular Biology, Reproductive Medicine, Public Health, Environmental and Occupational Health, Cell Biology, and Genetics.

Their work covers a range of main topics, particularly focusing on Sperm and Testicular Function and Reproductive Biology and Fertility. Additional topics of interest in their research include Nuclear Structure and Function, Cellular Transport and Secretion, Genetics and Neurodevelopmental Disorders, Signaling Pathways in Disease, and Renal and Related Cancers.

Walter Witke's recent papers include:

  • Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2, 2020, published in Cells
  • Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization, 2021, published in Frontiers in Cell and Developmental Biology
  • Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis, 2023, published in Development
  • Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus, 2020, published in Journal of Cell Science
  • Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory, 2024, published in bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors who have collaborated on multiple projects with Walter Witke are:

  • Lena Arévalo
  • Keerthika Lohanadan
  • Hubert Schorle
  • Naila Umer
  • Sharang Phadke

The scientist has published regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cells, Frontiers in Cell and Developmental Biology, Development, and the Journal of Cell Science.

Best Publications

  • The role of profilin complexes in cell motility and other cellular processes.

    Walter Witke

  • The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

    Ilaria Napoli;Ilaria Napoli;Valentina Mercaldo;Pietro Pilo Boyl;Boris Eleuteri

  • Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

    Walter Witke;Arlene H Sharpe;John H Hartwig;Toshifumi Azuma

  • Mena is required for neurulation and commissure formation.

    Lorene M Lanier;Monte A Gates;Walter Witke;A.Sheila Menzies

  • In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

    Walter Witke;Alexander V. Podtelejnikov;Alessia Di Nardo;James D. Sutherland

  • Gelsolin is a downstream effector of rac for fibroblast motility

    Toshifumi Azuma;Walter Witke;Thomas P. Stossel;John H. Hartwig

  • Profilin I is essential for cell survival and cell division in early mouse development

    Walter Witke;James D. Sutherland;Arlene Sharpe;Maya Arai

  • The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons.

    Katsutoshi Furukawa;Weiming Fu;Ying Li;Walter Witke

  • The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration.

    Christine B. Gurniak;Emerald Perlas;Walter Witke

  • RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.

    Jorge Santos Da Silva;Miguel Medina;Cecilia Zuliani;Alessia Di Nardo

  • EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway

    Heng Xie;Manuel A. Pallero;Kiran Gupta;Philip Chang

  • Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

    Marco B Rust;Marco B Rust;Christine B Gurniak;Christine B Gurniak;Marianne Renner;Marianne Renner;Hugo Vara

  • ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

    Kevin C. Flynn;Kevin C. Flynn;Farida Hellal;Dorothee Neukirchen;Sonja Jacob

  • Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system

    Schanila Nawaz;Schanila Nawaz;Paula Sánchez;Sebastian Schmitt;Sebastian Schmitt;Nicholas Snaidero;Nicholas Snaidero

  • Redundancy in the microfilament system: abnormal development of Dictyostelium cells lacking two F-actin cross-linking proteins.

    Walter Witke;Michael Schleicher;Angelika A. Noegel

  • N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex

    Gian Carlo Bellenchi;Christine B. Gurniak;Emerald Perlas;Silvia Middei

  • Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing

    Walter Witke;Wei Li;David J. Kwiatkowski;Frederick S. Southwick

  • Delayed retraction of filopodia in gelsolin null mice.

    Mei Lu;Walter Witke;David J. Kwiatkowski;Kenneth S. Kosik

  • Coordinated Regulation of Platelet Actin Filament Barbed Ends by Gelsolin and Capping Protein

    Kurt Barkalow;Walter Witke;David J. Kwiatkowski;John H. Hartwig

  • SMN, profilin IIa and plastin 3: A link between the deregulation of actin dynamics and SMA pathogenesis

    Mélissa Bowerman;Mélissa Bowerman;Carrie L. Anderson;Carrie L. Anderson;Ariane Beauvais;Ariane Beauvais;Pietro Pilo Boyl

Frequent Co-Authors

Marco Sassoè-Pognetto
Marco Sassoè-Pognetto University of Turin
Eckhard Friauf
Eckhard Friauf Technical University of Kaiserslautern
David J. Kwiatkowski
David J. Kwiatkowski Brigham and Women's Hospital
Bernhard Nieswandt
Bernhard Nieswandt University of Würzburg
John H. Hartwig
John H. Hartwig Brigham and Women's Hospital
Frank Bradke
Frank Bradke German Center for Neurodegenerative Diseases
Matthias W. Hentze
Matthias W. Hentze European Molecular Biology Laboratory
Maurizio Giustetto
Maurizio Giustetto University of Turin
Arlene H. Sharpe
Arlene H. Sharpe Harvard University

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