World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
40
Citations
21331
World Ranking
7960
National Ranking
183

Overview

Ueli Gubler is affiliated with Roche (Switzerland) and has a research portfolio spanning biochemistry, genetics, molecular biology, and medicine. Their work intersects multiple subfields including molecular biology, infectious diseases, parasitology, epidemiology, and organic chemistry.

The scientist's research topics cover diverse areas such as parasitic diseases research and treatment, parasites and host interactions, Trypanosoma species research and implications, advanced biosensing and bioanalysis techniques, DNA and nucleic acid chemistry, RNA interference and gene delivery, and synthesis and reactivity of heterocycles.

Ueli Gubler has contributed to several scientific publications. Notable recent papers include:

  • Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate, 2023, PLoS neglected tropical diseases
  • A beginners guide to SELEX and DNA aptamers, 2025, Analytical Biochemistry
  • A Novel Strategy for Identifying Non-covalent KRas Inhibitors, 2020, Medical Research Archives
  • Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase, 2020, Archives of Biochemistry and Biophysics

Frequent coauthors in their research include Nina M. Goodey, Tyler Eck, Cheryl A. Janson, Keith Lange, and Kathleen M. Frey, with multiple collaborations documented.

The scientist's frequent publication venues reflect the interdisciplinary nature of their research, featuring journals such as PLoS neglected tropical diseases, Analytical Biochemistry, Medical Research Archives, and Archives of Biochemistry and Biophysics.

Best Publications

  • A simple and very efficient method for generating cDNA libraries

    Ueli Gubler;Beth J. Hoffman

  • THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

    Maurice K. Gately;Louis M. Renzetti;Jeanne Magram;Alvin S. Stern

  • Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells.

    Susanne J. Szabo;Anand S. Dighe;Ueli Gubler;Kenneth M. Murphy

  • Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

    Peter T. Lomedico;Ueli Gubler;Christopher P. Hellmann;Mitchell Dukovich

  • Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

    Lars Rogge;Luisella Barberis-Maino;Mauro Biffi;Nadia Passini

  • A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

    David H. Presky;Hong Yang;Lisa J. Minetti;Anne O. Chua

  • Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

    U Gubler;A O Chua;D S Schoenhaut;C M Dwyer

  • Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides

    U. Gubler;Peter H. Seeburg;B. J. Hoffman;L. P. Gage

  • Cloning and expression of murine IL-12.

    D S Schoenhaut;A O Chua;A G Wolitzky;P M Quinn

  • Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

    M K Gately;B B Desai;A G Wolitzky;P M Quinn

  • Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

    Silke Gillessen;Daisy Carvajal;Ping Ling;Frank J. Podlaski

  • Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

    Ping Ling;M. K. Gately;U. Gubler;A. S. Stern

  • Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

    T S Kupper;D W Ballard;A O Chua;J S McGuire

  • Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation

    T S Kupper;A O Chua;P Flood;J McGuire

  • Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

    Hideaki Tahara;Herbert J. Zeh;Walter J. Storkus;Itzhak Pappo

  • Two high-affinity interleukin 1 receptors represent separate gene products.

    Richard Chizzonite;Terri Truitt;Patricia L. Kilian;Alvin S. Stern

  • TWO HUMAN TNF RECEPTORS HAVE SIMILAR EXTRACELLULAR, BUT DISTINCT INTRACELLULAR, DOMAIN SEQUENCES

    Zlatko Dembic;Hansruedi Loetscher;Ueli Gubler;Yu-Ching E. Pan

  • Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

    H. Tahara;L. Zitvogel;W. J. Storkus;H. J. Zeh

  • Recombinant human interleukin 1 alpha: purification and biological characterization.

    U Gubler;A O Chua;A S Stern;C P Hellmann

  • Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells.

    P L Kilian;K L Kaffka;A S Stern;D Woehle

  • Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin

    U Gubler;J J Monahan;P T Lomedico;R S Bhatt

Frequent Co-Authors

Zlatko Dembic
Zlatko Dembic University of Oslo
Joseph F. McGuire
Joseph F. McGuire University of California, Los Angeles
Floyd E. Bloom
Floyd E. Bloom Scripps Research Institute

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