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Immunology

D-Index
55
Citations
9932
World Ranking
3816
National Ranking
146

Overview

Stefan Nierkens is affiliated with the University Medical Center Utrecht in the Netherlands. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with particular focus on Immunology, Hematology, and Oncology as significant subfields.

Their main research topics include hematopoietic stem cell transplantation, CAR-T cell therapy research, immune cell function and interaction, acute myeloid leukemia research, T-cell and B-cell immunology, acute lymphoblastic leukemia research, and immunotherapy and immune responses.

Stefan Nierkens has contributed to publications in several scientific venues, with frequent publications appearing in bioRxiv (Cold Spring Harbor Laboratory), Blood, Cancers, Frontiers in Immunology, and Neuro-Oncology. These venues reflect a focus on immunology, hematology, oncology, and related biomedical sciences.

Recent papers authored or co-authored by Stefan Nierkens include:

  • MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy, 2020, Cancers
  • The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology, 2020, European Journal of Cancer
  • Uncovering the mode of action of engineered T cells in patient cancer organoids, 2022, Nature Biotechnology
  • Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers, 2020, Journal of Allergy and Clinical Immunology
  • Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis, 2021, Journal of Investigative Dermatology

They have collaborated frequently with several co-authors, including Caroline A. Lindemans, Jaap Jan Boelens, Eveline M. Delemarre, Annelisa M. Cornel, and Mirjam E. Belderbos. These collaborations suggest ongoing research efforts in immunology and hematology-related projects.

Best Publications

  • MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy.

    Annelisa M. Cornel;Iris L. Mimpen;Stefan Nierkens

  • Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

    M H M G M den Brok;R P M Sutmuller;S Nierkens;E J Bennink

  • Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

    W. Joost Lesterhuis;Cornelis J.A. Punt;Stanleyson V. Hato;Dagmar Eleveld-Trancikova

  • Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

    Joannes F M Jacobs;Stefan Nierkens;Carl G Figdor;I Jolanda M de Vries

  • CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

    Oliver M. Grauer;Stefan Nierkens;Erik Bennink;Liza W.J. Toonen

  • Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

    Joannes F.M. Jacobs;Albert J. Idema;Kalijn F. Bol;Stefan Nierkens

  • Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine

    Martijn H.M.G.M. den Brok;Roger P.M. Sutmuller;Stefan Nierkens;Erik J. Bennink

  • Uncovering the mode of action of engineered T cells in patient cancer organoids

    Unknown

  • Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a retrospective, pharmacodynamic cohort analysis

    Rick Admiraal;Rick Admiraal;Stefan Nierkens;Moniek A de Witte;Eefke J Petersen

  • Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation.

    Rick Admiraal;Caroline A. Lindemans;Charlotte van Kesteren;Marc B. Bierings

  • The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology.

    Judith Wienke;Miranda P. Dierselhuis;Godelieve A.M. Tytgat;Annette Künkele

  • TLR ligands in the local treatment of established intracerebral murine gliomas.

    Oliver M. Grauer;Johan W. Molling;Erik Bennink;Liza W. J. Toonen

  • Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis.

    Judith L. Thijs;Ian Strickland;Carla A.F.M. Bruijnzeel-Koomen;Stefan Nierkens

  • Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

    Stefan Nierkens;Jurjen Tel;Edith Janssen;Gosse J. Adema

  • Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells.

    Stefan Nierkens;Martijn H. den Brok;Zacharias Garcia;Susan Togher

  • Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

    Joris M. Van Montfrans;Esther A. R. Hartman;Kees P. J. Braun;Eric A. M. Hennekam

  • Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry.

    Lieneke F M Ariëns;Jorien van der Schaft;Daphne S Bakker;Deepak Balak

  • Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation

    Rick Admiraal;Coco C.H. de Koning;Caroline A. Lindemans;Marc B. Bierings

  • Toll-like receptor signalling on Tregs: to suppress or not to suppress?

    Wendy W C van Maren;Joannes F M Jacobs;I Jolanda M de Vries;Stefan Nierkens

  • Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate‐pulsed dendritic cells in a murine glioma model

    Oliver M. Grauer;Roger P.M. Sutmuller;Roger P.M. Sutmuller;Wendy van Maren;Joannes F.M. Jacobs

  • Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

    J Van Montfrans;E Hartman;K Braun;F Hennekam

Frequent Co-Authors

Gosse J. Adema
Gosse J. Adema Radboud University
Raymond Pieters
Raymond Pieters Utrecht University
Edward F. Knol
Edward F. Knol Utrecht University
Louis Boon
Louis Boon University of Amsterdam
Marianne Boes
Marianne Boes Utrecht University
Carl G. Figdor
Carl G. Figdor Radboud University
Timothy R D J Radstake
Timothy R D J Radstake Utrecht University
Leo Koenderman
Leo Koenderman Utrecht University
Guillermo Sanz
Guillermo Sanz Hospital Universitari i Politècnic La Fe

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