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Stefan Frohling

Stefan Frohling

D-Index & Metrics

Medicine

D-Index
84
Citations
36730
World Ranking
14870
National Ranking
784

Overview

Stefan Frohling is affiliated with the DKFZ-ZMBH Alliance in Germany and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans particularly within molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and genetics.

The scientist's work focuses on varied topics such as cancer genomics and diagnostics, sarcoma diagnosis and treatment, lung cancer treatments and mutations, epigenetics and DNA methylation, pancreatic and hepatic oncology research, cancer immunotherapy and biomarkers, and acute myeloid leukemia research.

Stefan Frohling has authored multiple papers, including notable publications like:

  • Accurate and efficient detection of gene fusions from RNA sequencing data, 2021, Genome Research
  • The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K, 2020, Nature
  • Caring for patients with cancer in the COVID-19 era, 2020, Nature Medicine
  • Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers, 2021, Cancer Discovery
  • Small-molecule-induced polymerization triggers degradation of BCL6, 2020, Nature

Frequent co-authors in their research collaborations include:

  • Peter Horak
  • Albrecht Stenzinger
  • Hanno Glimm
  • Daniel Hübschmann
  • Christoph E. Heilig

The scientist often publishes in the following venues:

  • Annals of Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • European Journal of Cancer

Best Publications

  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

    Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

    Richard F. Schlenk;Konstanze Döhner;Jürgen Krauter;Stefan Fröhling

  • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia.

    Lars Bullinger;Konstanze Döhner;Eric Bair;Stefan Fröhling

  • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

    Stefan Fröhling;Richard F. Schlenk;Jochen Breitruck;Axel Benner

  • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.

    Konstanze Döhner;Richard F Schlenk;Marianne Habdank;Claudia Scholl

  • Activating mutations in ALK provide a therapeutic target in neuroblastoma

    Rani E. George;Takaomi Sanda;Megan C. Hanna;Stefan Fröhling

  • Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction : Results of the Ex-DHF (Exercise training in Diastolic Heart Failure) Pilot Study

    Frank Edelmann;Götz Gelbrich;Hans-Dirk Düngen;Stefan Fröhling

  • TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.

    Frank G. Rücker;Richard F. Schlenk;Lars Bullinger;Sabine Kayser

  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

    Claudia Scholl;Stefan Fröhling;Ian F. Dunn;Anna C. Schinzel

  • CEBPA Mutations in Younger Adults With Acute Myeloid Leukemia and Normal Cytogenetics: Prognostic Relevance and Analysis of Cooperating Mutations

    Stefan Fröhling;Richard F. Schlenk;Ina Stolze;Jörg Bihlmayr

  • Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications

    Stefan Fröhling;Claudia Scholl;D. Gary Gilliland;Ross L. Levine

  • Prognostic Significance of Partial Tandem Duplications of the MLL Gene in Adult Patients 16 to 60 Years Old With Acute Myeloid Leukemia and Normal Cytogenetics: A Study of the Acute Myeloid Leukemia Study Group Ulm

    Konstanze Döhner;Karen Tobis;Regina Ulrich;Stefan Fröhling

  • Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

    Michael G Kharas;Michael G Kharas;Christopher J Lengner;Fatima Al-Shahrour;Fatima Al-Shahrour;Lars Bullinger

  • Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B

    Stefan Fröhling;Richard F Schlenk;Sabine Kayser;Martina Morhardt

  • BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

    Simon Raffel;Mattia Falcone;Niclas Kneisel;Jenny Hansson

  • Caring for patients with cancer in the COVID-19 era.

    Joris van de Haar;Louisa R. Hoes;Charlotte E. Coles;Kenneth Seamon

  • Accurate and efficient detection of gene fusions from RNA sequencing data.

    Sebastian Uhrig;Julia Ellermann;Tatjana Walther;Pauline Burkhardt;Pauline Burkhardt

  • Chromosomal abnormalities in cancer

    Stefan Fröhling;Hartmut Döhner

  • AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

    Stephen M. Sykes;Steven W. Lane;Lars Bullinger;Demetrios Kalaitzidis

Frequent Co-Authors

Lars Bullinger
Lars Bullinger Charité - University Medicine Berlin
Hanno Glimm
Hanno Glimm TU Dresden
Peter Horak
Peter Horak University of Southampton
Richard F. Schlenk
Richard F. Schlenk University Hospital Heidelberg
Barbara Hutter
Barbara Hutter German Cancer Research Center
Benedikt Brors
Benedikt Brors German Cancer Research Center
Hartmut Döhner
Hartmut Döhner University of Ulm
Dirk Jäger
Dirk Jäger Heidelberg University
Wilko Weichert
Wilko Weichert Technical University of Munich

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