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Biology and Biochemistry

D-Index
74
Citations
17417
World Ranking
5676
National Ranking
2689

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stanley C. Froehner is affiliated with the University of Washington in the United States. Their research contributions span multiple fields within medicine and biochemistry, genetics, and molecular biology.

The scientist has published extensively, with a focus on muscle physiology and disorders as well as adipose tissue and metabolism. Their work also delves into ion channel regulation and function, mitochondrial function and pathology, receptor mechanisms and signaling, sirtuins and resveratrol in medicine, and ion transport and channel regulation.

Recent publications by Stanley C. Froehner include the following papers:

  • Orchestrating aquaporin-4 and connexin-43 expression in brain: Differential roles of α1- and β1-syntrophin, 2021, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Functional specialization of retinal Müller cell endfeet depends on an interplay between two syntrophin isoforms, 2020, Molecular Brain
  • Ultrastructural localization of the Mr 43,000 protein and the acetylcholine receptor in Torpedo postsynaptic membranes using monoclonal antibodies, 2020, UNC Libraries
  • Rebuttal to: Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy, Verhaart et al. 2020, 2021, Journal of Neuromuscular Diseases
  • Differential Association of Syntrophin Pairs with the Dystrophin Complex, 2021, UNC Libraries

Frequent collaborators in Stanley C. Froehner's research include Marvin E. Adams, Neal R. Kramarcy, Robert Sealock, Stephen Gee, and Robert J. Sealock.

The majority of their research output has appeared in the UNC Libraries publication venue, along with publications in Biochimica et Biophysica Acta (BBA) - Biomembranes, Molecular Brain, Journal of Neuromuscular Diseases, and the Journal of the American Society of Nephrology.

Within their main fields of study, Stanley C. Froehner has produced work in medicine and biochemistry, genetics, and molecular biology. Subfields include molecular biology, physiology, neurology, cellular and molecular neuroscience, and oncology.

Topics regularly addressed in their research are:

  • Muscle Physiology and Disorders
  • Adipose Tissue and Metabolism
  • Ion channel regulation and function
  • Mitochondrial Function and Pathology
  • Receptor Mechanisms and Signaling
  • Sirtuins and Resveratrol in Medicine
  • Ion Transport and Channel Regulation

Stanley C. Froehner was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

    Jay E Brenman;Daniel S Chao;Stephen H Gee;Aaron W McGee

  • An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain

    Mahmood Amiry-Moghaddam;Takashi Otsuka;Patricia D. Hurn;Richard J. Traystman

  • Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein

    John D. Neely;Mahmood Amiry-Moghaddam;Ole Petter Ottersen;Stanley C. Froehner

  • Delayed K+ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice

    Mahmood Amiry-Moghaddam;Anne Williamson;Maria Palomba;Tore Eid

  • Interaction of Muscle and Brain Sodium Channels with Multiple Members of the Syntrophin Family of Dystrophin-Associated Proteins

    Stephen H. Gee;Raghavan Madhavan;S. Rock Levinson;John H. Caldwell

  • rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

    Paul Gregorevic;James M Allen;Elina Minami;Michael J Blankinship

  • Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy

    David G. Allen;Nicholas P. Whitehead;Stanley C. Froehner

  • Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood–brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia

    Mahmood Amiry-Moghaddam;Rong Xue;Finn Mogens Haug;John D. Neely

  • The postsynaptic 43k protein clusters muscle nicotinic acetylcholine receptors in xenopus oocytes

    Stanley C. Froehner;Charles W. Luetje;Paula B. Scotland;Jim Patrick

  • Differential Association of Syntrophin Pairs with the Dystrophin Complex

    Matthew F. Peters;Marvin E. Adams;Stanley C. Froehner

  • Absence of α-Syntrophin Leads to Structurally Aberrant Neuromuscular Synapses Deficient in Utrophin

    Marvin E. Adams;Neal Kramarcy;Stuart P. Krall;Susana G. Rossi

  • Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution

    Marvin E. Adams;Margaret H. Butler;Timothy M. Dwyer;Timothy M. Dwyer;Matthew F. Peters

  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain.

    Gregory E. Crawford;John A. Faulkner;Rachelle H. Crosbie;Kevin P. Campbell

  • Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

    Dmitri Leonoudakis;Lisa R. Conti;Scott Anderson;Carolyn M. Radeke

  • In vivo requirement of the α-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4

    Marvin E. Adams;Heather A. Mueller;Stanley C. Froehner

  • Skeletal Muscle NADPH Oxidase Is Increased and Triggers Stretch-Induced Damage in the mdx Mouse

    Nicholas P. Whitehead;Ella W. Yeung;Stanley C. Froehner;David G. Allen

  • The Potassium Channel Kir4.1 Associates with the Dystrophin-Glycoprotein Complex via α-Syntrophin in Glia

    Nathan C. Connors;Marvin E. Adams;Stanley C. Froehner;Paulo Kofuji

  • The submembrane machinery for nicotinic acetylcholine receptor clustering.

    S C Froehner

  • Regulation of ion channel distribution at synapses.

    S C Froehner

  • Association of utrophin and multiple dystrophin short forms with the mammalian M(r) 58,000 dystrophin-associated protein (syntrophin)

    N. R. Kramarcy;A. Vidal;S. C. Froehner;Robert W Sealock

Frequent Co-Authors

Joseph A. Beavo
Joseph A. Beavo University of Washington
Ole Petter Ottersen
Ole Petter Ottersen University of Oslo
Kathryn N. North
Kathryn N. North University of Melbourne
Jeffrey S. Chamberlain
Jeffrey S. Chamberlain University of Washington
Paul L. Huang
Paul L. Huang Harvard University
David Mowat
David Mowat University of New South Wales
Louis M. Kunkel
Louis M. Kunkel Boston Children's Hospital
Peter Agre
Peter Agre Johns Hopkins University
Moses V. Chao
Moses V. Chao New York University

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