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Biology and Biochemistry

D-Index
91
Citations
29419
World Ranking
2327
National Ranking
49

Overview

Roger M. Nitsch is affiliated with the University of Zurich in Switzerland. Their research primarily spans the fields of medicine and neuroscience, with a notable focus on neurology, physiology, radiology, nuclear medicine and imaging, molecular biology, and biomedical engineering. Throughout their career, they have contributed extensively to topics including Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, advanced neuroimaging techniques and applications, photoacoustic and ultrasonic imaging, dementia and cognitive impairment research, optical imaging and spectroscopy techniques, and tryptophan and brain disorders.

Their research output includes numerous papers published in high-impact venues. Some recent papers are:

  • Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid (2023) published in New England Journal of Medicine
  • APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes (2021) published in Stem Cell Reports
  • A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells (2021) published in Nature Communications
  • Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice (2022) published in Nature Biomedical Engineering
  • A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain (2020) published in Frontiers in Neuroscience

Roger M. Nitsch has frequently collaborated with several researchers, including:

  • Christoph Höck
  • Ruiqing Ni
  • Daniel Razansky
  • Anton Gietl
  • Valérie Treyer

Many of their publications appear in a variety of research venues. Among the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Nature Communications
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Stem Cell Reports

Best Publications

  • The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

    Jeff Sevigny;Ping Chiao;Thierry Bussière;Paul H Weinreb

  • Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils

    J. Götz;F. Chen;J. van Dorpe;R. M. Nitsch

  • Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

    Christoph Hock;Uwe Konietzko;Johannes R Streffer;Jay Tracy

  • Acute cortisone administration impairs retrieval of long-term declarative memory in humans.

    Dominique J.-F. de Quervain;Dominique J.-F. de Quervain;Benno Roozendaal;Roger M. Nitsch;James L. McGaugh

  • Tau Filament Formation in Transgenic Mice Expressing P301L Tau

    Jürgen Götz;Feng Chen;Robi Barmettler;Roger M. Nitsch

  • The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

    Ruth C. von Rotz;Bernhard M. Kohli;Jérôme Bosset;Michelle Meier

  • Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe.

    Dominique J.-F. De Quervain;Katharina Henke;Amanda Aerni;Valerie Treyer

  • Low-dose cortisol for symptoms of posttraumatic stress disorder.

    Amanda Aerni;Rafael Traber;Christoph Hock;Benno Roozendaal

  • Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

    Christoph Hock;Uwe Konietzko;Andreas Papassotiropoulos;Axel Wollmer

  • Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice.

    Marlen Knobloch;Uwe Konietzko;Danielle C. Krebs;Roger M. Nitsch

  • The Human DIMINUTO/DWARF1 Homolog Seladin-1 Confers Resistance to Alzheimer's Disease-Associated Neurodegeneration and Oxidative Stress

    Isabell Greeve;Irm Hermans-Borgmeyer;Claire Brellinger;Dagmar Kasper

  • Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila

    Isabell Greeve;Doris Kretzschmar;Jakob Andreas Tschäpe;Anika Beyn

  • Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers

    Christian R. A. Mondadori;Dominique J. F. de Quervain;Andreas Buchmann;Henrietta Mustovic

  • Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

    Roger M. Nitsch;Meihua Deng;John H. Growdon;Richard J. Wurtman

  • Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease

    Giancarlo V. De Ferrari;Andreas Papassotiropoulos;Andreas Papassotiropoulos;Travis Biechele;Fabienne Wavrant De-Vrieze

  • Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

    Robert K. K. Lee;Richard J. Wurtman;Alice J. Cox;Roger M. Nitsch

  • Biochemical Diagnosis of Alzheimer Disease by Measuring the Cerebrospinal Fluid Ratio of Phosphorylated tau Protein to β-Amyloid Peptide42

    Alessia Maddalena;Andreas Papassotiropoulos;Britta Müller-Tillmanns;Hans H. Jung

  • High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different Genes

    Ulrich Finckh;Tomas Müller-Thomsen;Ulrike Mann;Christian Eggers

  • Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.

    Andreas Papassotiropoulos;Johannes R. Streffer;Magdalini Tsolaki;Simon Schmid

  • Reduced Protein Phosphatase 2A Activity Induces Hyperphosphorylation and Altered Compartmentalization of Tau in Transgenic Mice

    Stefan Kins;Arames Crameri;David R. H. Evans;Brian A. Hemmings

Frequent Co-Authors

Christoph Hock
Christoph Hock University of Zurich
Andreas Papassotiropoulos
Andreas Papassotiropoulos University of Basel
Valerie Treyer
Valerie Treyer University of Zurich
Alfred Buck
Alfred Buck University of Zurich
Jürgen Götz
Jürgen Götz University of Queensland
John H. Growdon
John H. Growdon Harvard University
Paul H. Weinreb
Paul H. Weinreb Biogen (United States)
Dominique J.-F. de Quervain
Dominique J.-F. de Quervain University of Basel
Giuliano Binetti
Giuliano Binetti Sacred Heart Hospital
Markus Rudin
Markus Rudin ETH Zurich

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