His Mechanistic target of rapamycin research extends to the thematically linked field of Cell biology. He integrates Mechanistic target of rapamycin with mTORC1 in his study. His work in mTORC1 is not limited to one particular discipline; it also encompasses PI3K/AKT/mTOR pathway. His PI3K/AKT/mTOR pathway study frequently links to adjacent areas such as RHEB. His RHEB study frequently links to other fields, such as Cell biology. Roberto Zoncu combines Enzyme and Cancer cell in his studies. His work often combines Cancer cell and Apoptosis studies. He merges many fields, such as Apoptosis and Programmed cell death, in his writings. His Biochemistry research extends to Programmed cell death, which is thematically connected.
Cell biology and Phosphorylation are frequently intertwined in his study. He conducts interdisciplinary study in the fields of Phosphorylation and mTORC1 through his works. His research links GTPase with Biochemistry. Borrowing concepts from Gene, he weaves in ideas under GTPase. He integrates many fields in his works, including Gene and Cell. He combines Cell and Biochemistry in his research. Roberto Zoncu conducts interdisciplinary study in the fields of Enzyme and Amino acid through his works. While working on this project, Roberto Zoncu studies both Amino acid and Signal transduction. Roberto Zoncu performs integrative study on Signal transduction and Receptor.
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mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu;Alejo Efeyan;David M. Sabatini.
Nature Reviews Molecular Cell Biology (2011)
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak;Liron Bar-Peled;Roberto Zoncu;Andrew L. Markhard.
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre;Carmine Settembre;Roberto Zoncu;Diego L Medina;Francesco Vetrini;Francesco Vetrini.
The EMBO Journal (2012)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu;Liron Bar-Peled;Alejo Efeyan;Shuyu Wang.
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Kirill Bersuker;Joseph M. Hendricks;Zhipeng Li;Leslie Magtanong.
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Liron Bar-Peled;Lawrence D. Schweitzer;Roberto Zoncu;David M. Sabatini.
Origin of GABAergic neurons in the human neocortex
Kresimir Letinic;Roberto Zoncu;Pasko Rakic.
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Shuyu Wang;Zhi-Yang Tsun;Rachel L. Wolfson;Kuang Shen.
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
Gaurav Sahay;William Querbes;Christopher Alabi;Ahmed Eltoukhy.
Nature Biotechnology (2013)
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Rushika M. Perera;Svetlana Stoykova;Brandon N. Nicolay;Kenneth N. Ross.
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