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Biology and Biochemistry

D-Index
49
Citations
30818
World Ranking
17802
National Ranking
7284

Overview

Roberto Zoncu is affiliated with the University of California, Berkeley in the United States. Their primary research fields span Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on subfields including Molecular Biology, Cell Biology, Physiology, Epidemiology, and Surgery.

The research work of Roberto Zoncu concentrates on several key topics, notably:

  • Cellular transport and secretion
  • Autophagy in Disease and Therapy
  • Calcium signaling and nucleotide metabolism
  • Lysosomal Storage Disorders Research
  • Cholesterol and Lipid Metabolism
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer, Lipids, and Metabolism

Zoncu has been a contributor to numerous scientific papers. Important recent publications include:

  • "NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C," 2020, Developmental Cell
  • "The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease," 2023, Nature Reviews Molecular Cell Biology
  • "Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1," 2022, Science
  • "The Lysosome at the Intersection of Cellular Growth and Destruction," 2020, Developmental Cell
  • "Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis," 2022, Molecular Metabolism

Frequent collaborators of Roberto Zoncu include:

  • Rushika M. Perera
  • Hijai R. Shin
  • Y. Rose Citron
  • Gilles Rademaker
  • James H. Hurley

The scientist's research output is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Developmental Cell
  • Nature
  • Science Advances
  • Nature Reviews Molecular Cell Biology

Best Publications

  • mTOR: from growth signal integration to cancer, diabetes and ageing

    Roberto Zoncu;Alejo Efeyan;David M. Sabatini

  • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

    Yasemin Sancak;Liron Bar-Peled;Roberto Zoncu;Andrew L. Markhard

  • The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

    Kirill Bersuker;Joseph M. Hendricks;Zhipeng Li;Leslie Magtanong

  • A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

    Carmine Settembre;Carmine Settembre;Roberto Zoncu;Diego L Medina;Francesco Vetrini;Francesco Vetrini

  • mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

    Roberto Zoncu;Liron Bar-Peled;Alejo Efeyan;Shuyu Wang

  • Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

    Liron Bar-Peled;Lawrence D. Schweitzer;Roberto Zoncu;David M. Sabatini

  • Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

    Gaurav Sahay;William Querbes;Christopher Alabi;Ahmed Eltoukhy

  • Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

    Shuyu Wang;Zhi-Yang Tsun;Rachel L. Wolfson;Kuang Shen

  • Origin of GABAergic neurons in the human neocortex

    Kresimir Letinic;Roberto Zoncu;Pasko Rakic

  • The lysosome as a cellular centre for signalling, metabolism and quality control.

    Rosalie E Lawrence;Roberto Zoncu

  • Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

    Rushika M. Perera;Svetlana Stoykova;Brandon N. Nicolay;Kenneth N. Ross

  • The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

    Zhi-Yang Tsun;Liron Bar-Peled;Lynne Chantranupong;Roberto Zoncu

  • Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

    Pekka Katajisto;Julia Döhla;Christine L. Chaffer;Nalle Pentinmikko

  • Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin

    Gilbert Di Paolo;Lorenzo Pellegrini;Lorenzo Pellegrini;Kresimir Letinic;Gianluca Cestra

  • The Lysosome as a Regulatory Hub

    Rushika M. Perera;Roberto Zoncu

  • Amino acids and mTORC1: from lysosomes to disease

    Alejo Efeyan;Roberto Zoncu;David M. Sabatini

  • DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

    Truc B. Nguyen;Sharon M. Louie;Joseph R. Daniele;Quan Tran

  • Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex

    Brian M. Castellano;Ashley M. Thelen;Ofer Moldavski;McKenna Feltes

  • Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

    Alejo Efeyan;Roberto Zoncu;Steven Chang;Iwona Gumper

  • A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

    Roberto Zoncu;Rushika M. Perera;Daniel M. Balkin;Michelle Pirruccello

Frequent Co-Authors

James H. Hurley
James H. Hurley University of California, Berkeley
Derek Toomre
Derek Toomre Yale University
Daniel K. Nomura
Daniel K. Nomura University of California, Berkeley
Pietro De Camilli
Pietro De Camilli Yale University
Daniel S. Ory
Daniel S. Ory Washington University in St. Louis
Timothy C. Wang
Timothy C. Wang Columbia University
Douglas F. Covey
Douglas F. Covey Washington University in St. Louis
Sridhar Ramaswamy
Sridhar Ramaswamy Harvard University
Wilhelm Haas
Wilhelm Haas Harvard University

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