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Biology and Biochemistry

D-Index
56
Citations
21021
World Ranking
14151
National Ranking
5966

Overview

Derek Toomre is affiliated with Yale University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Cell Biology, Biophysics, Genetics, and Biomedical Engineering.

The main topics of Derek Toomre's work include:

  • Cellular transport and secretion
  • Advanced Fluorescence Microscopy Techniques
  • Lipid Membrane Structure and Behavior
  • Genetic and Kidney Cyst Diseases
  • Advanced Electron Microscopy Techniques and Applications
  • Cell Adhesion Molecules Research
  • Photosynthetic Processes and Mechanisms

Derek Toomre has published extensively in several scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Biophysical Journal
  • Nature Cardiovascular Research

Some recent publications highlight the scope and direction of Toomre's research activity:

  • "Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes," 2020, Science Advances
  • "Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging," 2024, Cell
  • "Extremely Bright, Near-IR Emitting Spontaneously Blinking Fluorophores Enable Ratiometric Multicolor Nanoscopy in Live Cells," 2021, ACS Central Science
  • "Two-color nanoscopy of organelles for extended times with HIDE probes," 2020, Nature Communications
  • "An active tethering mechanism controls the fate of vesicles," 2021, Nature Communications

Frequent collaborators in their research include Félix Rivera-Molina, Zhiqun Xi, Erdem Karatekin, Joerg Bewersdorf, and Ane Landajuela.

Best Publications

  • Lipid rafts and signal transduction

    Kai Simons;Derek Toomre

  • Spatial control of EGF receptor activation by reversible dimerization on living cells

    Inhee Chung;Robert Akita;Richard Vandlen;Derek Toomre

  • Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms

    Fang Huang;Tobias M P Hartwich;Tobias M P Hartwich;Tobias M P Hartwich;Felix E Rivera-Molina;Yu Lin

  • Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

    Amy Chow;Derek Toomre;Wendy Garrett;Ira Mellman

  • Multicolour imaging of post-Golgi sorting and trafficking in live cells

    Patrick Keller;Derek Toomre;Elena Díaz;Jamie White;Jamie White

  • Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains

    Jaime Millán;Lindsay Hewlett;Matthew Glyn;Derek Toomre

  • Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

    Vincent Idone;Christina Tam;John W. Goss;Derek Toomre

  • The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.

    Takahiro Murata;Anna Delprato;Alyssa Ingmundson;Derek K Toomre

  • A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

    Roberto Zoncu;Rushika M. Perera;Daniel M. Balkin;Michelle Pirruccello

  • Lighting up the cell surface with evanescent wave microscopy

    Derek Toomre;Derek Toomre;Dietmar J. Manstein

  • A new wave of cellular imaging.

    Derek Toomre;Joerg Bewersdorf

  • Optogenetic control of phosphoinositide metabolism

    Olof Idevall-Hagren;Eamonn J. Dickson;Bertil Hille;Derek K. Toomre

  • Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells

    Derek Toomre;Patrick Keller;Jamie White;Jean-Christophe Olivo

  • Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate

    Roberto Zoncu;Rushika M. Perera;Rafael Sebastian;Fubito Nakatsu

  • Ultra-High Resolution 3D Imaging of Whole Cells

    Fang Huang;Fang Huang;George Sirinakis;George Sirinakis;Edward S. Allgeyer;Edward S. Allgeyer;Lena K. Schroeder

  • Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking

    Yasuko Iwakiri;Yasuko Iwakiri;Ayano Satoh;Suvro Chatterjee;Derek K. Toomre

  • A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

    Kai S. Erdmann;Kai S. Erdmann;Yuxin Mao;Yuxin Mao;Heather J. McCrea;Heather J. McCrea;Roberto Zoncu;Roberto Zoncu

  • The Tyrosine Kinase Activity of c-Src Regulates Actin Dynamics and Organization of Podosomes in Osteoclasts

    Olivier Destaing;Archana Sanjay;Cecile Itzstein;William C. Horne

  • Golgi biogenesis in Toxoplasma gondii

    Laurence Pelletier;Charlene A. Stern;Marc Pypaert;David Sheff

  • Golgi duplication in Trypanosoma brucei

    Cynthia Y. He;Helen H. Ho;Joerg Malsam;Cecile Chalouni

Frequent Co-Authors

Roberto Zoncu
Roberto Zoncu University of California, Berkeley
Pietro De Camilli
Pietro De Camilli Yale University
Alanna Schepartz
Alanna Schepartz University of California, Berkeley
James S. Duncan
James S. Duncan Yale University
James E. Rothman
James E. Rothman Yale University
Ira Mellman
Ira Mellman Parker Institute for Cancer Immunotherapy
Kai Simons
Kai Simons Lipotype
Marc Pypaert
Marc Pypaert Yale University
Ajit Varki
Ajit Varki University of California, San Diego
William C. Sessa
William C. Sessa Pfizer (United States)

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