World's Best Scientists 2026 revealed!

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Immunology

D-Index
55
Citations
11679
World Ranking
3799
National Ranking
175

Overview

Régis Josien is affiliated with Grenoble Alpes University in France. Their research output spans multiple topics predominantly in Medicine and Immunology and Microbiology. The scientist has contributed extensively to fields including Immunology, Infectious Diseases, Oncology, Surgery, and Epidemiology.

Their main areas of study cover immune system mechanisms and therapeutic approaches. Specific research topics include:

  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • SARS-CoV-2 and COVID-19 Research
  • Renal Transplantation Outcomes and Treatments
  • IL-33, ST2, and ILC Pathways

Recent publications reflect these foci with studies published in a range of journals between 2020 and 2022. Key recent papers include:

  • "Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials", 2020, The Lancet
  • "PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy", 2020, Journal for ImmunoTherapy of Cancer
  • "An easy and reliable whole blood freezing method for flow cytometry immuno-phenotyping and functional analyses", 2021, Cytometry Part B Clinical Cytometry
  • "A Phase I/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients", 2022, Kidney International
  • "Characterization of Rat ILCs Reveals ILC2 as the Dominant Intestinal Subset", 2020, Frontiers in Immunology

The scientist has frequently published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Transplantation
  • Frontiers in Immunology
  • The Journal of Immunology
  • Blood Advances

Coauthorship patterns show collaboration with several researchers multiple times, including:

  • Cécile Braudeau
  • Gilles Blancho
  • Jérôme C. Martin
  • Laurence Bouchet-Delbos
  • Aurélie Moreau

This profile reflects a scientific career concentrated on advancing understanding and therapeutic strategies in immunology-related disciplines, with a specific emphasis on transplantation and immune cell characterization.

Best Publications

  • TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

    Brian R. Wong;Régis Josien;Soo Young Lee;Birthe Sauter

  • The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

    Brian R. Wong;Régis Josien;Soo Young Lee;Masha Vologodskaia

  • Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression.

    Christine Chauveau;Séverine Rémy;Pierre Joseph Royer;Marcelo Hill

  • Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

    Birgit Sawitzki;Paul N Harden;Petra Reinke;Aurélie Moreau

  • Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo

    Régis Josien;Hong-Li Li;Elizabeth Ingulli;Supria Sarma;Supria Sarma

  • TRANCE, a TNF Family Member, Is Differentially Expressed on T Cell Subsets and Induces Cytokine Production in Dendritic Cells

    Régis Josien;Brian R. Wong;Hong-Li Li;Ralph M. Steinman

  • A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation

    Nacksung Kim;Masamichi Takami;Jaerang Rho;Regis Josien

  • TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation.

    Martin F. Bachmann;Brian R. Wong;Régis Josien;Ralph M. Steinman

  • Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

    Dongku Kim;Reina E. Mebius;John D. MacMicking;Steffen Jung

  • TRANCE is a TNF family member that regulates dendritic cell and osteoclast function.

    Brian R. Wong;Regis Josien;Yongwon Choi;Yongwon Choi

  • TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection

    Jose M. Trevejo;Michael W. Marino;Nicola Philpott;Regis Josien

  • CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase.

    Carole Guillonneau;Marcelo Hill;François-Xavier Hubert;Elise Chiffoleau

  • A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.

    R Josien;P Douillard;C Guillot;M Müschen

  • Acute graft pyelonephritis and long-term kidney allograft outcome.

    Magali Giral;Giovani Pascuariello;Georges Karam;Maryvonne Hourmant

  • Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness.

    Caroline Hémont;Antoine Neel;Michèle Heslan;Cécile Braudeau

  • IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS‐treated dendritic cells

    Marcelo Hill;Marcelo Hill;Séverine Tanguy-Royer;Pierre Royer;Christine Chauveau;Christine Chauveau

  • Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism

    Régis Josien;Michèle Heslan;Jean-Paul Soulillou;Maria-Cristina Cuturi

  • Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

    Jérôme C. Martin;Dominique L. Baeten;Régis Josien

  • Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

    J. C. J. Martin;G. Beriou;M. Heslan;C. Chauvin

  • Rat Plasmacytoid Dendritic Cells Are an Abundant Subset of MHC Class II+ CD4+CD11b−OX62− and Type I IFN-Producing Cells That Exhibit Selective Expression of Toll-Like Receptors 7 and 9 and Strong Responsiveness to CpG

    Francois-Xavier Hubert;Cécile Voisine;Cédric Louvet;Michèle Heslan

Frequent Co-Authors

Maria-Cristina Cuturi
Maria-Cristina Cuturi University of Nantes
Ignacio Anegon
Ignacio Anegon University of Nantes
Jean-Paul Soulillou
Jean-Paul Soulillou University of Nantes
Yongwon Choi
Yongwon Choi University of Pennsylvania
Sophie Brouard
Sophie Brouard University of Nantes
Edward K. Geissler
Edward K. Geissler University of Regensburg
Ralph M. Steinman
Ralph M. Steinman Rockefeller University
Markus Müschen
Markus Müschen Yale University
Jean-Christophe Renauld
Jean-Christophe Renauld Université Catholique de Louvain
Maria G. Castro
Maria G. Castro University of Michigan–Ann Arbor

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