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Immunology

D-Index
51
Citations
8863
World Ranking
4154
National Ranking
1895

Overview

Michael R. Holbrook is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on infectious diseases within the field of medicine, with an emphasis on SARS-CoV-2 and COVID-19 related studies.

The scientist's contributions to the field are reflected by publications in notable venues including bioRxiv (Cold Spring Harbor Laboratory), Antiviral Research, The Journal of Infectious Diseases, Cell Host & Microbe, and JCI Insight.

Holbrook's main areas of study cover:

  • Infectious Diseases
  • Epidemiology
  • Animal Science and Zoology
  • Molecular Biology
  • Immunology

The topics most frequently addressed in their work include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Viral Infections and Outbreaks Research
  • Viral Infections and Vectors
  • Animal Virus Infections Studies
  • Viral gastroenteritis research and epidemiology
  • SARS-CoV-2 detection and testing

Some recent research papers authored or co-authored by Holbrook are:

  • Broadly neutralizing antibodies target the coronavirus fusion peptide, 2022, Science
  • Defining the risk of SARS-CoV-2 variants on immune protection, 2022, Nature
  • Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern, 2021, Science Translational Medicine
  • Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates, 2020, Journal of Clinical Investigation
  • Naturally Acquired SARS-CoV-2 Immunity Persists for Up to 11 Months Following Infection, 2021, The Journal of Infectious Diseases

Frequent co-authors collaborating with Holbrook include Elena Postnikova, Janie Liang, Louis Huzella, Brett Eaton, and Yu Cong.

Best Publications

  • Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

    Julie Dyall;Christopher M. Coleman;Brit J. Hart;Thiagarajan Venkataraman

  • Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

    Jason Kindrachuk;Britini Ork;Brit J. Hart;Steven Mazur

  • The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

    Maudry Laurent-Rolle;Elena F. Boer;Kirk J. Lubick;James B. Wolfinbarger

  • Defining the risk of SARS-CoV-2 variants on immune protection

    Unknown

  • Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays.

    Brit J. Hart;Julie Dyall;Elena Postnikova;Huanying Zhou

  • Broadly neutralizing antibodies target the coronavirus fusion peptide

    Unknown

  • Possible sexual transmission of ebola virus — Liberia, 2015

    Athalia Christie;Gloria J. Davies-Wayne;Thierry Cordier-Lasalle;David J. Blackley

  • Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

    Mohammad F. Saeed;Andrey A. Kolokoltsov;Alexander N. Freiberg;Michael R. Holbrook

  • Biophysical Characterization and Vector-Specific Antagonist Activity of Domain III of the Tick-Borne Flavivirus Envelope Protein

    S. Bhardwaj;M. Holbrook;R. E. Shope;Alan Barrett

  • Historical Perspectives on Flavivirus Research

    Michael R. Holbrook

  • Ubiquitin-Regulated Nuclear-Cytoplasmic Trafficking of the Nipah Virus Matrix Protein Is Important for Viral Budding

    Yao E. Wang;Arnold Park;Michael Lake;Mickey Pentecost

  • Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine.

    Joseph E. Blaney;Andrea Marzi;Mallory Willet;Amy B. Papaneri

  • Kyasanur forest disease.

    Michael R. Holbrook

  • Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography

    Alexander N. Freiberg;Michael B. Sherman;Marc C. Morais;Michael R. Holbrook

  • Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.

    Alexander N. Freiberg;Melissa N. Worthy;Benhur Lee;Benhur Lee;Michael R. Holbrook

  • Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.

    David E. Volk;David W.C. Beasley;Deborah A. Kallick;Michael R. Holbrook

  • MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells.

    Yu Cong;Brit J. Hart;Robin Gross;Huanying Zhou

  • T-705 (Favipiravir) Inhibition of Arenavirus Replication in Cell Culture

    Michelle Mendenhall;Andrew Russell;Terry Juelich;Emily L. Messina

  • Single-particle cryo-electron microscopy of Rift Valley fever virus.

    Michael B. Sherman;Alexander N. Freiberg;Michael R. Holbrook;Stanley J. Watowich

  • Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.

    Hyeseon Cho;Kristina Kay Gonzales-Wartz;Deli Huang;Meng Yuan

  • Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.

    Thomas Luke;Hua Wu;Jincun Zhao;Jincun Zhao;Rudragouda Channappanavar

  • Antiviral activities of ISG20 in positive-strand RNA virus infections.

    Zhi Zhou;Nan Wang;Sara E. Woodson;Qingming Dong

  • Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses

    Joseph E. Blaney;Christoph Wirblich;Amy B. Papaneri;Reed F. Johnson

  • Inactivation and safety testing of Middle East Respiratory Syndrome Coronavirus.

    Mia Kumar;Steven Mazur;Britini L. Ork;Elena Postnikova

  • Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

    Nadezhda E. Yun;Nathaniel S. Linde;Michele A. Zacks;Ian G. Barr

  • Japanese Encephalitis Vaccines.

    Monica A McArthur;Michael R Holbrook

Frequent Co-Authors

Peter B. Jahrling
Peter B. Jahrling National Institute of Allergy and Infectious Diseases
Lisa E. Hensley
Lisa E. Hensley National Institutes of Health
Alexander N. Freiberg
Alexander N. Freiberg The University of Texas Medical Branch at Galveston
Alan D.T. Barrett
Alan D.T. Barrett The University of Texas Medical Branch at Galveston
Gene G. Olinger
Gene G. Olinger Boston University
Jens H. Kuhn
Jens H. Kuhn National Institutes of Health
David W.C. Beasley
David W.C. Beasley The University of Texas Medical Branch at Galveston
Matthew B. Frieman
Matthew B. Frieman University of Maryland, Baltimore
Robert E. Shope
Robert E. Shope The University of Texas Medical Branch at Galveston
Benhur Lee
Benhur Lee Icahn School of Medicine at Mount Sinai

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