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Immunology

D-Index
60
Citations
10083
World Ranking
3367
National Ranking
292

Overview

Margaret M. Harnett is affiliated with the University of Glasgow in the United Kingdom and has produced a significant body of research primarily in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Parasitology, Molecular Biology, Immunology, Public Health, Environmental and Occupational Health, and Physiology.

Harnett's research interests focus on parasitic interactions, immune responses, cellular mechanisms, genetics related to aging and longevity, gut microbiota, and dietary effects on health. The main topics covered by their studies include:

  • Parasites and Host Interactions
  • Research on Leishmaniasis Studies
  • Cellular Mechanics and Interactions
  • Genetics, Aging, and Longevity in Model Organisms
  • Gut microbiota and health
  • Dietary Effects on Health
  • Immune responses and vaccinations

Their published papers illustrate a consistent focus on parasitic worm products and their biological impacts, particularly connected to inflammation, aging, and immune system regulation. Notable recent publications include:

  • The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing (2020, PLoS Pathogens)
  • Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts (2021, PLoS Pathogens)
  • Epigenetic changes induced by parasitic worms and their excretory-secretory products (2024, Biochemical Society Transactions)
  • The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing (2022, Frontiers in Immunology)
  • Conquering rheumatic diseases: are parasitic worms the answer? (2023, Trends in Parasitology)

Margaret M. Harnett collaborates frequently with a group of co-authors who contribute to shared research interests and publications. These co-authors include William Harnett, Miguel A. Pineda, Felicity E. Lumb, James Doonan, and Geraldine Buitrago.

Their work is commonly published in scientific journals such as Frontiers in Immunology, bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, Frontiers in Tropical Diseases, and Biochemical Society Transactions, with multiple studies appearing in these venues over the course of their career.

Best Publications

  • MAPKs and their relevance to arthritis and inflammation

    T. Thalhamer;M. A. McGrath;M. M. Harnett

  • A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells

    Michael Whelan;Margaret M. Harnett;Katrina M. Houston;Vanshree Patel

  • Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase

    Gui-Jie Feng;Helen S. Goodridge;Margaret M. Harnett;Xiao Qing Wei

  • Immunomodulation via Novel Use of TLR4 by the Filarial Nematode Phosphorylcholine-Containing Secreted Product, ES-62

    Helen S. Goodridge;Fraser A. Marshall;Kathryn J. Else;Katrina M. Houston

  • IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62

    Dimity H. Ball;Lamyaa Al-Riyami;William Harnett;Margaret M. Harnett

  • Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

    Alirio J. Melendez;Margaret M. Harnett;Peter N. Pushparaj;Ws Fred Wong

  • A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62

    Iain B. McInnes;Bernard P. Leung;Margaret Harnett;J. Alastair Gracie

  • Helminth-derived immunomodulators: can understanding the worm produce the pill?

    William Harnett;Margaret M. Harnett

  • Phosphorylcholine: friend or foe of the immune system?

    William Harnett;Margaret M Harnett

  • Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses

    Helen S Goodridge;William Harnett;Foo Y Liew;Margaret M Harnett

  • Leukocytes are primed in peripheral blood for activation during term and preterm labour

    M. Yuan;F. Jordan;I.B. McInnes;M.M. Harnett

  • Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product.

    W Harnett;M M Harnett

  • Modulation of Macrophage Cytokine Production by ES-62, a Secreted Product of the Filarial Nematode Acanthocheilonema viteae

    Helen S. Goodridge;Emma H. Wilson;William Harnett;Carol C. Campbell

  • Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter.

    David J. Welsh;Margaret Harnett;Margaret MacLean;Andrew J. Peacock

  • Receptor signalling and crosstalk in B lymphocytes.

    G. G. B. Klaus;M. K. Bijsterbosch;A. O'garra;M. M. Harnett

  • The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis

    M.M. Harnett;Dorothy E. Kean;A. Boitelle;S. McGuiness

  • Laser scanning cytometry: understanding the immune system in situ.

    Margaret M. Harnett

  • Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.

    Alison M Michie;Margaret Lobban;Thomas Müller;Margaret M Harnett

  • The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites.

    Miguel A. Pineda;Mairi A. McGrath;Pauline C. Smith;Lamyaa Al-Riyami

  • Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

    Lamyaa Al-Riyami;Miguel A Pineda;Justyna Rzepecka;Judith K Huggan

  • Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein.

    William Harnett;Maureen R. Deehan;Katrina M. Houston;Margaret M. Harnett

Frequent Co-Authors

William Harnett
William Harnett University of Strathclyde
Iain B. McInnes
Iain B. McInnes University of Glasgow
Foo Y. Liew
Foo Y. Liew University of Glasgow
Paul Garside
Paul Garside University of Glasgow
Michael J. O. Wakelam
Michael J. O. Wakelam Babraham Institute
Colin Selman
Colin Selman University of Glasgow
Rudolf Geyer
Rudolf Geyer University of Giessen
Allan McI. Mowat
Allan McI. Mowat University of Glasgow
Bernard P. Leung
Bernard P. Leung Singapore Institute of Technology
Gordon Langsley
Gordon Langsley Université Paris Cité

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