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Medicine

D-Index
108
Citations
48130
World Ranking
5951
National Ranking
65

Overview

Luc Dirix is affiliated with GZA Ziekenhuizen Campus Sint-Augustinus in Belgium and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research focuses prominently on Oncology, with particular emphasis on Cancer Research, Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging, and Surgery.

The scientist's main research topics cover:

  • Breast Cancer Treatment Studies
  • Cancer Cells and Metastasis
  • Medical Imaging and Pathology Studies
  • Cancer Immunotherapy and Biomarkers
  • Advanced Breast Cancer Therapies
  • Cancer Genomics and Diagnostics
  • Estrogen and related hormone effects

Selected recent publications by Luc Dirix include:

  • Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study, 2022, The Lancet Oncology
  • An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver, 2023, Nature Communications
  • Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity, 2020, Breast Cancer Research and Treatment
  • Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase IIb Trial, 2023, Clinical Cancer Research
  • Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer-Treated with Neoadjuvant Systemic Therapy, 2023, Cancer Research Communications

Luc Dirix has published multiple articles in prominent scientific journals, frequently contributing to:

  • Clinical Cancer Research
  • Cancer Research
  • The Breast
  • The Lancet Oncology
  • Nature Communications

The scientist has collaborated regularly with the following coauthors:

  • François Bertucci
  • Patrick Neven
  • Steven Van Laere
  • Hans Wildiers
  • Ha-Linh Nguyen

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Serena Nik-Zainal;Serena Nik-Zainal;Helen Davies;Johan Staaf;Manasa Ramakrishna

  • Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

    Aleksandar Sekulic;Michael R. Migden;Anthony E. Oro;Luc Dirix

  • Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial

    Robert L Coleman;Amit M Oza;Domenica Lorusso;Carol Aghajanian

  • Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer

    David W. Miles;Arlene Chan;Luc Y. Dirix;Javier Cortés

  • Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

    François-Clément Bidard;François-Clément Bidard;Dieter Peeters;Tanja Fehm;Franco Nolé

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation

    P. E. Vermeulen;G. Gasparini;S. B. Fox;Masakazu Toi

  • Exemestane Is Superior to Megestrol Acetate After Tamoxifen Failure in Postmenopausal Women With Advanced Breast Cancer: Results of a Phase III Randomized Double-Blind Trial

    M Kaufmann;E Bajetta;L Y Dirix;L E Fein

  • Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study.

    Luc Y. Dirix;Istvan Takacs;Guy Jerusalem;Petros Nikolinakos

  • Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours.

    P.B. Vermeulen;G. Gasparini;S.B. Fox;C. Colpaert

  • Neratinib, an Irreversible ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced ErbB2-Positive Breast Cancer

    Harold J. Burstein;Yan Sun;Luc Y. Dirix;Zefei Jiang

  • Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial

    Manish R. Patel;John Ellerton;Jeffrey R. Infante;Manish Agrawal

  • Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel

    M. Aapro;P. A. Abrahamsson;J. J. Body;R. E. Coleman

  • Circulating interleukin-6 predicts survival in patients with metastatic breast cancer.

    Roberto Salgado;Sara Junius;Ina Benoy;Peter Van Dam

  • International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment

    S. Dawood;S. D. Merajver;P. Viens;P. B. Vermeulen

  • Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

    Sung-Bae Kim;Rebecca Dent;Seock-Ah Im;Marc Espié

  • Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse

    M. Brada;K. Hoang-Xuan;R. Rampling;P. Y. Dietrich

  • Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial

    Michael R. Migden;Alexander Guminski;Ralf Gutzmer;Luc Dirix

  • Phase II Randomized Study of Trastuzumab Emtansine Versus Trastuzumab Plus Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer

    Sara A. Hurvitz;Luc Dirix;Judit Kocsis;Giulia V. Bianchi

Frequent Co-Authors

Peter B. Vermeulen
Peter B. Vermeulen University of Antwerp
Eric Van Marck
Eric Van Marck University of Antwerp
Caroline Seynaeve
Caroline Seynaeve Erasmus University Rotterdam
John W.M. Martens
John W.M. Martens Erasmus University Rotterdam
John M. S. Bartlett
John M. S. Bartlett University of Toronto
Stefan Sleijfer
Stefan Sleijfer Erasmus University Rotterdam
Roberto Salgado
Roberto Salgado Peter MacCallum Cancer Centre
Ahmad Awada
Ahmad Awada Université Libre de Bruxelles
Cornelis J.H. van de Velde
Cornelis J.H. van de Velde Leiden University Medical Center
Martine Piccart
Martine Piccart Université Libre de Bruxelles

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