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81
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Research.com Recognitions

  • 2010 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Pathology and Forensic Medicine

Overview

Karl H. Plate is affiliated with Goethe University Frankfurt in Germany. Their research spans multiple fields primarily within Medicine as well as Biochemistry, Genetics, and Molecular Biology, with focused subfields in Genetics, Oncology, Pulmonary and Respiratory Medicine, Molecular Biology, and Immunology.

Their work addresses several main topics, including:

  • Glioma Diagnosis and Treatment
  • Brain Metastases and Treatment
  • CAR-T cell therapy research
  • Epigenetics and DNA Methylation
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses

Karl H. Plate has contributed to various publications, with recent papers such as:

  • "Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma," 2023, Neuro-Oncology
  • "Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis," 2021, Nature Cancer
  • "DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma," 2021, Journal for ImmunoTherapy of Cancer
  • "The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis," 2021, EMBO Molecular Medicine
  • "HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis," 2020, Acta Neuropathologica

Frequent co-authors of Karl H. Plate include:

  • Yvonne Reiss
  • Jadranka Macas
  • Patrick N. Harter
  • Pia S. Zeiner
  • Joachim P. Steinbach

Their publications have appeared predominantly in the following venues:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Brain Pathology
  • Research Square (Research Square)

Karl H. Plate received recognition from the German National Academy of Sciences Leopoldina (Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften) in 2010 for work related to Pathology and Forensic Medicine.

Best Publications

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

    Millauer B;Shawver Lk;Plate Kh;Risau W

  • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

    B. Oosthuyse;L. Moons;E. Storkebaum;H. Beck

  • Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

    Veerle Compernolle;Koen Brusselmans;Till Acker;Peter Hoet

  • Functional morphology of the blood-brain barrier in health and disease.

    Stefan Liebner;Rick M. Dijkhuizen;Yvonne Reiss;Karl H. Plate

  • Wnt/β-catenin signaling controls development of the blood–brain barrier

    Stefan Liebner;Monica Corada;Thorsten Bangsow;Jane Babbage

  • Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

    Astrid Stratmann;Werner Risau;Karl H. Plate

  • Dominant-Negative Inhibition of Flk-1 Suppresses the Growth of Many Tumor Types in Vivo

    Birgit Millauer;Michael P. Longhi;Karl H. Plate;Laura K. Shawver

  • Vascular Endothelial Growth Factor and Glioma Angiogenesis: Coordinate Induction of VEGF Receptors, Distribution of VEGF Protein and Possible In Vivo Regulatory Mechanisms

    K H Plate;G Breier;H A Weich;H D Mennel

  • Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

    Marion Krieg;Richard Haas;Hiltrud Brauch;Till Acker

  • Mechanisms of Angiogenesis in the Brain

    Karl H. Plate

  • Angiogenesis in malignant gliomas

    Karl H. Plate;Werner Risau

  • Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor

    Anne Schänzer;Frank-Peter Wachs;Daniel Wilhelm;Till Acker

  • Angiogenesis after cerebral ischemia.

    Heike Beck;Karl H. Plate

  • Suppression of antitumor T cell immunity by the oncometabolite ( R )-2-hydroxyglutarate

    Lukas Bunse;Stefan Pusch;Theresa Bunse;Felix Sahm

  • Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

    Kirsten Ridder;Sascha Keller;Maria Dams;Anne-Kathleen Rupp

  • Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney

    M. Simon;H. J. Grone;O. Johren;J. Kullmer

  • Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

    Seth B. Coffelt;Andrea O. Tal;Alexander Scholz;Michele De Palma

  • Uncontrolled Expression of Vascular Endothelial Growth Factor and Its Receptors Leads to Insufficient Skin Angiogenesis in Patients With Systemic Sclerosis

    Oliver Distler;Jörg H. W. Distler;Annette Scheid;Till Acker

  • Vascular endothelial growth factor

    Karl H. Plate;Peter C. Warnke

Frequent Co-Authors

Werner Risau
Werner Risau Max Planck Society
David Capper
David Capper Charité - University Medicine Berlin
Volker Seifert
Volker Seifert Goethe University Frankfurt
Ivan Dikic
Ivan Dikic Goethe University Frankfurt
Andreas von Deimling
Andreas von Deimling Heidelberg University
Felix Sahm
Felix Sahm University Hospital Heidelberg
Desire Collen
Desire Collen KU Leuven
Reinhard Henschler
Reinhard Henschler Ludwig-Maximilians-Universität München
Daniel J. Dumont
Daniel J. Dumont University of Toronto
Stefanie Dimmeler
Stefanie Dimmeler Goethe University Frankfurt

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