What is he best known for?
The fields of study he is best known for:
Jeffrey H. Grubb focuses on Biochemistry, Molecular biology, Endocrinology, Internal medicine and Mucopolysaccharidosis VII.
His study in the field of Peptide sequence, Active site and Enzyme is also linked to topics like HFE Protein.
Jeffrey H. Grubb combines subjects such as Amino acid, Expressed sequence tag and Carbonic anhydrase with his study of Peptide sequence.
His study in the field of Protomer also crosses realms of Dimer.
Pharmacology, Glucuronidase, Transcytosis and Receptor is closely connected to Mannose in his research, which is encompassed under the umbrella topic of Molecular biology.
His Mucopolysaccharidosis VII study incorporates themes from Distribution, Mucopolysaccharidosis, Immunology and Meninges.
His most cited work include:
- Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers (297 citations)
- The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells. (217 citations)
- Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. (202 citations)
What are the main themes of his work throughout his whole career to date?
Molecular biology, Biochemistry, Enzyme, Mucopolysaccharidosis and Mucopolysaccharidosis VII are his primary areas of study.
His Molecular biology research incorporates themes from Genetics, Mutant, Complementary DNA, Western blot and Carbonic anhydrase.
In his research on the topic of Carbonic anhydrase, Protein structure is strongly related with Transmembrane protein.
His Enzyme study integrates concerns from other disciplines, such as Beta-glucuronidase, Kidney and Recombinant DNA.
His research in Mucopolysaccharidosis intersects with topics in Spleen, Immunology, Endocrinology and Sulfatase.
His studies in Mannose integrate themes in fields like Lysosomal storage disease, Receptor, Mannose 6-phosphate receptor and Glycosylation.
He most often published in these fields:
- Molecular biology (50.00%)
- Biochemistry (42.68%)
- Enzyme (31.71%)
What were the highlights of his more recent work (between 2008-2020)?
- Biochemistry (42.68%)
- Internal medicine (17.07%)
- Enzyme (31.71%)
In recent papers he was focusing on the following fields of study:
Jeffrey H. Grubb mostly deals with Biochemistry, Internal medicine, Enzyme, Endocrinology and Mucopolysaccharidosis VII.
His works in Fusion protein, Mannose and Chinese hamster ovary cell are all subjects of inquiry into Biochemistry.
His Internal medicine research is multidisciplinary, incorporating perspectives in Antibody and Alkaline phosphatase.
The concepts of his Enzyme study are interwoven with issues in Intraperitoneal injection, Pharmacology and Bone lesion.
His work deals with themes such as Receptor, Mucopolysaccharidosis and Missense mutation, which intersect with Mucopolysaccharidosis VII.
Jeffrey H. Grubb works mostly in the field of Glucuronidase, limiting it down to concerns involving Kidney and, occasionally, Blood–brain barrier.
Between 2008 and 2020, his most popular works were:
- New strategies for enzyme replacement therapy for lysosomal storage diseases. (76 citations)
- Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome). (71 citations)
- Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII (48 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Lysosome, Neonatal Fc receptor, Mannose 6-phosphate receptor, Glycosylation and Biochemistry.
His Lysosome study combines topics from a wide range of disciplines, such as Receptor, Mannose and Fusion protein.
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