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Biology and Biochemistry

D-Index
53
Citations
8694
World Ranking
16310
National Ranking
6753

Overview

Jeffrey H. Grubb is affiliated with Saint Louis University in the United States. Their research spans fields including Medicine and Chemistry, with subfields such as Physiology, Epidemiology, and Organic Chemistry. The main topics of their research focus on Lysosomal Storage Disorders, Trypanosoma species and their implications, as well as Carbohydrate Chemistry and Synthesis.

The scientist has contributed to the following recent paper:

  • Vestronidase alfa: Recombinant human β-glucuronidase as an enzyme replacement therapy for MPS VII, 2020, Molecular Genetics and Metabolism

The publication appeared in Molecular Genetics and Metabolism, which is also among the frequent venues where their work is published.

Collaborations have been documented with several researchers, including:

  • Jaclyn Cadaoas
  • Gabrielle Boyle
  • Steven Jungles
  • Sean P. Cullen
  • Michel Vellard

These collaborations reflect the interdisciplinary nature of the scientist's work, spanning diverse areas related to their fields of study.

Best Publications

  • Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers

    Özlem Türeci;Ugur Sahin;Evi Vollmar;Stefan Siemer

  • Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

    Douglas A. Whittington;Abdul Waheed;Barbara Ulmasov;Gul N. Shah

  • The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.

    A Oshima;C M Nolan;J W Kyle;J H Grubb

  • Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.

    S Jain;W.B Drendel;Z.W Chen;F.S Mathews

  • Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII

    Carole Vogler;Beth Levy;Jeffrey H. Grubb;Nancy Galvin

  • Cloning, sequencing, and expression of cDNA for human. beta. -glucuronidase

    Akihiro Oshima;John W. Kyle;Raymond D. Miller;Joseph W. Hoffmann

  • ENZYME REPLACEMENT THERAPY FOR MURINE MUCOPOLYSACCHARIDOSIS TYPE VII

    M S Sands;C Vogler;J W Kyle;J H Grubb

  • Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.

    Akihiko Urayama;Jeffrey H. Grubb;William S. Sly;William A. Banks;William A. Banks

  • Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.

    Antti Kivelä;Seppo Parkkila;Juha Saarnio;Tuomo J. Karttunen

  • Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.

    Abdul Waheed;Jeffrey H. Grubb;Xiao Yan Zhou;Shunji Tomatsu

  • Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII

    Jeffrey H. Grubb;Carole Vogler;Beth Levy;Nancy Galvin

  • Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function.

    L H O'Connor;L C Erway;C A Vogler;W S Sly

  • Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain

    Seppo Parkkila;Anna-Kaisa Parkkila;Hannu Rajaniemi;Gul N. Shah

  • Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice.

    Jonathan H. LeBowitz;Jeffrey H. Grubb;John A. Maga;Deborah H. Schmiel

  • Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.

    Y Murayama;T Okamoto;E Ogata;T Asano

  • Murine mucopolysaccharidosis type VII: long term therapeutic effects of enzyme replacement and enzyme replacement followed by bone marrow transplantation.

    M S Sands;C Vogler;A Torrey;B Levy

  • The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase.

    J M Shipley;J H Grubb;W S Sly

  • Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome).

    Shunji Tomatsu;Adriana M. Montaño;Vu Chi Dung;Jeffrey H. Grubb

  • Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.

    Douglas A Whittington;Jeffrey H Grubb;Abdul Waheed;Gul N Shah

  • Enhancement of drug delivery to bone : Characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide

    Tatsuo Nishioka;Shunji Tomatsu;Monica A. Gutierrez;Ken-ichi Miyamoto

Frequent Co-Authors

William S. Sly
William S. Sly Saint Louis University
Shunji Tomatsu
Shunji Tomatsu Alfred I. duPont Hospital for Children
Abdul Waheed
Abdul Waheed Saint Louis University
Tadao Orii
Tadao Orii Gifu University
Naomi Kondo
Naomi Kondo Gifu University
William A. Banks
William A. Banks University of Washington
Seppo Parkkila
Seppo Parkkila Tampere University
Hannu Rajaniemi
Hannu Rajaniemi University of Oulu
Anna-Kaisa Parkkila
Anna-Kaisa Parkkila University of Oulu
Seiji Yamaguchi
Seiji Yamaguchi Shimane University

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