Jeffrey H. Grubb focuses on Biochemistry, Molecular biology, Endocrinology, Internal medicine and Mucopolysaccharidosis VII. His study in the field of Peptide sequence, Active site and Enzyme is also linked to topics like HFE Protein. Jeffrey H. Grubb combines subjects such as Amino acid, Expressed sequence tag and Carbonic anhydrase with his study of Peptide sequence.
His study in the field of Protomer also crosses realms of Dimer. Pharmacology, Glucuronidase, Transcytosis and Receptor is closely connected to Mannose in his research, which is encompassed under the umbrella topic of Molecular biology. His Mucopolysaccharidosis VII study incorporates themes from Distribution, Mucopolysaccharidosis, Immunology and Meninges.
Molecular biology, Biochemistry, Enzyme, Mucopolysaccharidosis and Mucopolysaccharidosis VII are his primary areas of study. His Molecular biology research incorporates themes from Genetics, Mutant, Complementary DNA, Western blot and Carbonic anhydrase. In his research on the topic of Carbonic anhydrase, Protein structure is strongly related with Transmembrane protein.
His Enzyme study integrates concerns from other disciplines, such as Beta-glucuronidase, Kidney and Recombinant DNA. His research in Mucopolysaccharidosis intersects with topics in Spleen, Immunology, Endocrinology and Sulfatase. His studies in Mannose integrate themes in fields like Lysosomal storage disease, Receptor, Mannose 6-phosphate receptor and Glycosylation.
Jeffrey H. Grubb mostly deals with Biochemistry, Internal medicine, Enzyme, Endocrinology and Mucopolysaccharidosis VII. His works in Fusion protein, Mannose and Chinese hamster ovary cell are all subjects of inquiry into Biochemistry. His Internal medicine research is multidisciplinary, incorporating perspectives in Antibody and Alkaline phosphatase.
The concepts of his Enzyme study are interwoven with issues in Intraperitoneal injection, Pharmacology and Bone lesion. His work deals with themes such as Receptor, Mucopolysaccharidosis and Missense mutation, which intersect with Mucopolysaccharidosis VII. Jeffrey H. Grubb works mostly in the field of Glucuronidase, limiting it down to concerns involving Kidney and, occasionally, Blood–brain barrier.
His scientific interests lie mostly in Lysosome, Neonatal Fc receptor, Mannose 6-phosphate receptor, Glycosylation and Biochemistry. His Lysosome study combines topics from a wide range of disciplines, such as Receptor, Mannose and Fusion protein.
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Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers
Özlem Türeci;Ugur Sahin;Evi Vollmar;Stefan Siemer.
Proceedings of the National Academy of Sciences of the United States of America (1998)
The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
A Oshima;C M Nolan;J W Kyle;J H Grubb.
Journal of Biological Chemistry (1988)
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
Douglas A. Whittington;Abdul Waheed;Barbara Ulmasov;Gul N. Shah.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.
S Jain;W.B Drendel;Z.W Chen;F.S Mathews.
Nature Structural & Molecular Biology (1996)
Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII
Carole Vogler;Beth Levy;Jeffrey H. Grubb;Nancy Galvin.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Cloning, sequencing, and expression of cDNA for human. beta. -glucuronidase
Akihiro Oshima;John W. Kyle;Raymond D. Miller;Joseph W. Hoffmann.
Proceedings of the National Academy of Sciences of the United States of America (1987)
ENZYME REPLACEMENT THERAPY FOR MURINE MUCOPOLYSACCHARIDOSIS TYPE VII
M S Sands;C Vogler;J W Kyle;J H Grubb.
Journal of Clinical Investigation (1994)
Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.
Akihiko Urayama;Jeffrey H. Grubb;William S. Sly;William A. Banks;William A. Banks.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.
Antti Kivelä;Seppo Parkkila;Juha Saarnio;Tuomo J. Karttunen.
American Journal of Pathology (2000)
Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.
Abdul Waheed;Jeffrey H. Grubb;Xiao Yan Zhou;Shunji Tomatsu.
Proceedings of the National Academy of Sciences of the United States of America (2002)
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