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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
13732
World Ranking
10799
National Ranking
4689

Overview

James C. Alwine is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on medicine with significant contributions to the fields of infectious diseases, public health, environmental and occupational health, modeling and simulation, epidemiology, and agronomy and crop science.

Throughout their career, Alwine has addressed multiple topics including SARS-CoV-2 and COVID-19 research, zoonotic diseases and public health, viral gastroenteritis research and epidemiology, COVID-19 epidemiological studies, animal disease management and epidemiology, ethics in clinical research, and health and medical research impacts.

The scientist's recent papers include:

  • A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses (2023, Journal of Virology)
  • The Harms of Promoting the Lab Leak Hypothesis for SARS-CoV-2 Origins Without Evidence (2024, Journal of Virology)

Alwine has frequently published in the following venues:

  • Journal of Virology
  • mBio
  • mSphere

The frequent co-authors collaborating with Alwine include:

  • Felicia Goodrum
  • Arturo Casadevall
  • Lynn W. Enquist
  • Michael J. Imperiale
  • Seema S. Lakdawala

Their body of work encompasses extensive studies on viral origins, virology discourse, and public health responses related to emerging infectious threats. The research addresses the scientific foundations of pandemic origins, epidemiological impacts, and the ethical dimensions within clinical research.

Best Publications

  • Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes

    James C. Alwine;David J. Kemp;George R. Stark

  • [15] Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper

    James C. Alwine;David J. Kemp;Barbara A. Parker;Jakob Reiser

  • Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication

    Janis M. Keller;James C. Alwine

  • Human Cytomegalovirus Infection Activates and Regulates the Unfolded Protein Response

    Jennifer A. Isler;Alison H. Skalet;James C. Alwine

  • The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

    Nicholas J. Buchkovich;Yongjun Yu;Carisa A. Zampieri;James C. Alwine

  • Autoregulation of simian virus 40 gene A by T antigen.

    Steven I. Reed;George R. Stark;James C. Alwine

  • Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences.

    S Carswell;J C Alwine

  • Distinct Microbial Signatures Associated With Different Breast Cancer Types.

    Sagarika Banerjee;Tian Tian;Zhi Wei;Natalie Shih

  • Characterization of the autoregulation of simian virus 40 gene A.

    James C. Alwine;Steven I. Reed;George R. Stark

  • Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

    Zandra E. Walton;Chirag H. Patel;Rebekah C. Brooks;Yongjun Yu

  • Human Cytomegalovirus Major Immediate-Early Proteins and Simian Virus 40 Large T Antigen Can Inhibit Apoptosis through Activation of the Phosphatidylinositide 3′-OH Kinase Pathway and the Cellular Kinase Akt

    Yongjun Yu;James C. Alwine

  • Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

    Carol S. Lutz;James C. Alwine

  • Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

    Carol Lutz;Kanneganti G.K. Murthy;Nancy Schek;James O'Connor

  • Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR Kinase

    Sagar B. Kudchodkar;Yongjun Yu;Tobi G. Maguire;James C. Alwine

  • The ovarian cancer oncobiome.

    Sagarika Banerjee;Tian Tian;Zhi Wei;Natalie Shih

  • Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex.

    D M Lukac;J R Manuppello;J C Alwine

  • Transcriptional activation by simian virus 40 large T antigen: interactions with multiple components of the transcription complex.

    M. C. Gruda;J. M. Zabolotny;Jia Hao Xiao;I. Davidson

  • The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

    Alexandra Valsamakis;Steven Zeichner;Susan Carswell;James C. Alwine

  • Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal.

    Charles Cooke;Holly Hans;James C. Alwine

  • Identification of a sequence element on the 3' side of AAUAAA which is necessary for Simian virus 40 late mRNA 3'-end processing

    Moshe Sadofsky;S. Connelly;J. L. Manley;J. C. Alwine

Frequent Co-Authors

Erle S. Robertson
Erle S. Robertson University of Pennsylvania
Michael Feldman
Michael Feldman University of Pennsylvania
Francisco Gonzalez-Scarano
Francisco Gonzalez-Scarano University of Pennsylvania
James C. Paton
James C. Paton University of Adelaide
Blossom Damania
Blossom Damania University of North Carolina at Chapel Hill
Adrienne W. Paton
Adrienne W. Paton University of Adelaide
Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
David K. Welsh
David K. Welsh University of California, San Diego
Thomas Shenk
Thomas Shenk Princeton University
M. Celeste Simon
M. Celeste Simon University of Pennsylvania

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