World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
8603
World Ranking
15802
National Ranking
1240

Research.com Recognitions

  • 1984 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ian C. Mackenzie is affiliated with Queen Mary University of London in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on oncology and cancer-related studies.

The scientist's work is notably centered on topics such as cancer cells and metastasis, cancer genomics and diagnostics, and cancer-related molecular mechanisms research. Additional areas of study include immunotherapy and immune responses, Hippo pathway signaling and YAP/TAZ, pluripotent stem cells research, and applications of 3D printing in biomedical research.

Ian C. Mackenzie has contributed to a range of recent scientific papers, including:

  • In vitro and in vivo characterization of cancer stem cell subpopulations in oral squamous cell carcinoma, 2020, Journal of Oral Pathology and Medicine
  • Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning, 2023, eLife
  • Disseminating cells in human oral tumours acquire an EMT cancer stem cell state that is predictive of metastasis, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction, 2023, International Journal of Molecular Sciences
  • A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance, 2025, BMC Biology

Their frequent collaborators include Adrian Biddle, Gehad Youssef, Luke Gammon, Michael P. Philpott, and Sophia Lunetto. These collaborations have contributed to multiple publications across various venues.

Ian C. Mackenzie has published in several scientific journals and platforms with recurring contributions to bioRxiv (Cold Spring Harbor Laboratory), the Journal of Oral Pathology and Medicine, eLife, the International Journal of Molecular Sciences, and BMC Biology.

Their work covers subfields such as oncology, cancer research, immunology, cell biology, and molecular biology. This multidisciplinary approach supports the investigation and understanding of cancer stem cells, tumor metastasis, and therapeutic resistance mechanisms.

In recognition of scientific contributions, Ian C. Mackenzie was named a Fellow of the American Association for the Advancement of Science (AAAS) in 1984.

Best Publications

  • Antibody markers of basal cells in complex epithelia

    P. E. Purkis;J. B. Steel;I. C. Mackenzie;W. B. J. Nathrath

  • Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

    Adrian Biddle;Xiao Liang;Luke Gammon;Bilal Fazil

  • Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines.

    Matthew Locke;Matthew Heywood;Stuart Fawell;Ian C. Mackenzie

  • BREAST CANCER FOLLOWING MULTIPLE FLUOROSCOPIES.

    Mackenzie I

  • Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma

    Lisa J. Harper;Kim Piper;John Common;Farida Fortune

  • Relationship between mitosis and the ordered structure of the stratum corneum in mouse epidermis.

    Mackenzie Ic

  • Cancer stem cells and EMT in carcinoma

    Adrian Biddle;Ian C. Mackenzie

  • Development of a quantitative method to analyse tumour cell invasion in organotypic culture

    Maria L Nystrom;G J Thomas;G J Thomas;M Stone;I C Mackenzie

  • Retroviral transduction of murine epidermal stem cells demonstrates clonal units of epidermal structure.

    Ian C. Mackenzie

  • Cytochemical identification of ATPase-positive langerhans cells in EDTA-separated sheets of mouse epidermis.

    I.C. Mackenzie;C.A. Squier

  • Regeneration of organized epithelial structure.

    Ian C. Mackenzie;Norbert E. Fusenig

  • Epithelial-mesenchymal interactions control basement membrane production and differentiation in cultured and transplanted mouse keratinocytes.

    Axel Bohnert;Jürgen Hornung;Ian C. Mackenzie;Norbert E. Fusenig

  • Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse

    Ian C. Mackenzie;Murray W. Hill

  • Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans

    Bethan Britt-Compton;Janet Maud Rowson;Matthew Locke;Ian Mackenzie

  • Identification and Localization of Label-Retaining Cells in Hamster Epithelia

    Jackie R Bickenbach;Ian C Mackenzie

  • Cancer stem cells – new and potentially important targets for the therapy of oral squamous cell carcinoma

    DE Costea;O Tsinkalovsky;OK Vintermyr;AC Johannessen

  • Keratin k15 as a biomarker of epidermal stem cells.

    Amrita Bose;Muy-Teck Teh;Ian C. Mackenzie;Ahmad Waseem

  • Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma.

    Adrian Biddle;Luke Gammon;Xiao Liang;Daniela Elena Costea

  • Label-retaining keratinocytes and Langerhans cells in mouse epithelia.

    I C Mackenzie;J R Bickenbach

  • Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance

    Lisa J Harper;Daniela Elena Costea;Luke Gammon;Luke Gammon;Bilal Fazil

Frequent Co-Authors

E. B. Lane
E. B. Lane Agency for Science, Technology and Research
Irene M. Leigh
Irene M. Leigh University of Dundee
Norbert E. Fusenig
Norbert E. Fusenig German Cancer Research Center
Edel A. O'Toole
Edel A. O'Toole Queen Mary University of London
Philip W. Wertz
Philip W. Wertz University of Iowa
John Doorbar
John Doorbar University of Cambridge
Herbert Pfister
Herbert Pfister University of Cologne
Trisha Greenhalgh
Trisha Greenhalgh University of Oxford
Duncan Martin Baird
Duncan Martin Baird Cardiff University
João F. Mano
João F. Mano University of Aveiro

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