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Genetics

D-Index
61
Citations
12357
World Ranking
3070
National Ranking
1341

Overview

Graeme Wistow is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

The scientist's work emphasizes several subfields of study including Molecular Biology, Ophthalmology, Radiology, Nuclear Medicine and Imaging, Materials Chemistry, and Cell Biology. Their research topics prominently feature Retinal Diseases and Treatments, Retinal Development and Disorders, Enzyme Structure and Function, Retinal Imaging and Analysis, Cellular transport and secretion, Protein Structure and Dynamics, and Biochemical effects in animals.

Among their recent publications are:

  • Amelotin is expressed in retinal pigment epithelium and localizes to hydroxyapatite deposits in dry age-related macular degeneration (2020, Translational research)
  • Molecular studies into cell biological role of Copine-4 in Retinal Ganglion Cells (2021, PLoS ONE)
  • Experimental NOE, Chemical Shift, and Proline Isomerization Data Provide Detailed Insights into Amelotin Oligomerization (2023, Journal of the American Chemical Society)
  • Serum-deprivation response of ARPE-19 cells; expression patterns relevant to age-related macular degeneration (2024, PLoS ONE)
  • Retbindin mediates light-damage in mouse retina while its absence leads to premature retinal aging (2021, Experimental Eye Research)

Their frequent coauthors include Dinusha Rajapakse, Katherine Peterson, Sanghamitra Mishra, Vatsala Sagar, and Joshua Lerner.

Common publication venues for the scientist include Translational research, PLoS ONE, bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Chemical Society, and Experimental Eye Research.

Best Publications

  • Lens Crystallins: The Evolution and Expression of Proteins for a Highly Specialized Tissue

    Graeme J. Wistow;Joram Piatigorsky

  • Usher Syndrome 1D and Nonsyndromic Autosomal Recessive Deafness DFNB12 Are Caused by Allelic Mutations of the Novel Cadherin-Like Gene CDH23

    Julie M. Bork;Linda M. Peters;Saima Riazuddin;Saima Riazuddin;Steve L. Bernstein

  • Enzyme/crystallins: Gene sharing as an evolutionary strategy

    Joram Piatigorsky;Graeme J. Wistow

  • Recruitment of enzymes as lens structural proteins.

    Graeme Wistow;Joram Piatigorsky

  • The Recruitment of Crystallins: New Functions Precede Gene Duplication

    J. Piatigorsky;G. Wistow

  • Gene sharing by delta-crystallin and argininosuccinate lyase.

    Joram Piatigorsky;William E. O'Brien;Barbara L. Norman;Karen Kalumuck

  • Lens crystallins: gene recruitment and evolutionary dynamism

    Graeme Wistow

  • The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lenses

    G. J. Wistow;J. W. M. Mulders;W. W. De Jong

  • Primary and secondary structure of bovine retinal S antigen (48-kDa protein)

    T Shinohara;B Dietzschold;C M Craft;G Wistow

  • Progressive juvenile-onset punctate cataracts caused by mutation of the γD-crystallin gene

    Dietrich A. Stephan;Elizabeth Gillanders;Deborah Vanderveen;Diana Freas-Lutz

  • A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.

    Graeme J. Wistow;Michael P. Shaughnessy;Douglas C. Lee;Jason Hodin

  • Domain structure and evolution in α‐crystallins and small heat‐shock proteins

    Graeme Wistow

  • Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.

    Stanislav I. Tomarev;Graeme Wistow;Vincent Raymond;Ste´phane Dubois

  • Evolution of a protein superfamily: relationships between vertebrate lens crystallins and microorganism dormancy proteins.

    Graeme Wistow

  • Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein.

    G J Wistow;T Lietman;L A Williams;S O Stapel

  • AIM1, a novel non-lens member of the βγ-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma

    Michael E. Ray;Graeme Wistow;Yan A. Su;Paul S. Meltzer

  • Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

    Deborah Carper;Chihiro Nishimura;Toshimichi Shinohara;Bernard Dietzchold

  • Evolution of crystallins for a role in the vertebrate eye lens

    Christine Slingsby;Graeme J. Wistow;Alice R. Clark

  • Functional impairment of lens aquaporin in two families with dominantly inherited cataracts

    Peter Francis;Jean Ju Chung;Masato Yasui;Vanita Berry

  • Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens beta gamma-crystallins.

    Graeme Wistow;Lesley Summers;Tom Blundell

Frequent Co-Authors

Joram Piatigorsky
Joram Piatigorsky National Institutes of Health
Robert N. Fariss
Robert N. Fariss National Institutes of Health
Larry L. David
Larry L. David Oregon Health & Science University
Peter Schuck
Peter Schuck National Institutes of Health
Stanislav I. Tomarev
Stanislav I. Tomarev National Institutes of Health
Christine A. Kozak
Christine A. Kozak National Institutes of Health
Cheryl M. Craft
Cheryl M. Craft University of Southern California
Vincent J. Hearing
Vincent J. Hearing National Institutes of Health
Michael A. Hauser
Michael A. Hauser Duke University
Jeffrey M. Trent
Jeffrey M. Trent Translational Genomics Research Institute

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