Eduardo G. Lapetina

Overview

Best Publications

• Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

  M M Billah;E G Lapetina;P Cuatrecasas

  503
  Citations

• Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance

  Kenji Ina;Jugoh Itoh;Kouhei Fukushima;Kazuo Kusugami

  498
  Citations

• Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents.

  B Brüne;E G Lapetina

  484
  Citations

• Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase.

  Susanne Mohr;Hazem Hallak;Alexander de Boitte;Eduardo G. Lapetina

  447
  Citations

• Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

  E G Lapetina;B Reep;B R Ganong;R M Bell

  412
  Citations

• The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

  S P Watson;R T McConnell;E G Lapetina

  397
  Citations

• Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

  M M Billah;E G Lapetina;P Cuatrecasas

  391
  Citations

• Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin.

  Eduardo G. Lapetina;Pedro Cuatrecasas

  384
  Citations

• Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

  L Molina y Vedia;B McDonald;B Reep;B Brüne

  369
  Citations

• Regulation of arachidonic acid production: role of phospholipases C and A2

  Eduardo G. Lapetina

  351
  Citations

• The phosphatidylinositol cycle and the regulation of arachidonic acid production

  Eduardo G. Lapetina;M. M. Billah;P. Cuatrecasas

  315
  Citations

• The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.

  E.G. Lapetina;M.M. Billah;P. Cuatrecasas

  310
  Citations

• Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide

  Susanne Mohr;Birgit Zech;Eduardo G. Lapetina;Bernhard Brüne

  307
  Citations

• 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

  Stephen P. Watson;Eduardo G. Lapetina

  291
  Citations

• Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.

  E.G. Lapetina;C.J. Schmitges;K. Chandrabose;P. Cuatrecasas

  283
  Citations

• Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation.

  W Siess;F L Siegel;E G Lapetina

  270
  Citations

• Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

  Stephen J. Brandt;Robert W. Dougherty;Eduardo G. Lapetina;James E. Niedel

  255
  Citations

• Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMP

  M.Motasim Billah;Eduardo G. Lapetina;Pedro Cuatrecasas

  225
  Citations

• Association of p21ras with phosphatidylinositol 3-kinase.

  Anita Sjolander;Kyohei Yamamoto;Brian E. Huber;Eduardo G. Lapetina

  224
  Citations

• Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C.

  Eduardo G. Lapetina;Bryan R. Reep

  200
  Citations