Hugues Chap

Overview

Best Publications

• Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition.

  Georgine Agullo;Laurence Gamet-Payrastre;Stéphane Manenti;Cécile Viala

  794
  Citations

• Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

  Olivier Fourcade;Marie-Françoise Simon;Cécile Viodé;Nathalie Rugani

  759
  Citations

• A role for phosphoinositide 3-kinase in bacterial invasion.

  Keith Ireton;Bernard Payrastre;Hugues Chap;Wataru Ogawa

  393
  Citations

• Flavonoids and the inhibition of PKC and PI 3-kinase.

  Laurence Gamet-Payrastre;Stéphane Manenti;Marie-Pierre Gratacap;Jacques Tulliez

  366
  Citations

• Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

  C Guinebault;B Payrastre;C Racaud-Sultan;H Mazarguil

  323
  Citations

• A Key Role of Adenosine Diphosphate in the Irreversible Platelet Aggregation Induced by the PAR1-Activating Peptide Through the Late Activation of Phosphoinositide 3-Kinase

  Catherine Trumel;Bernard Payrastre;Monique Plantavid;Béatrice Hechler

  307
  Citations

• Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases

  A Barrans;X Collet;R Barbaras;B Jaspard

  302
  Citations

• A Genetic Defect in Phosphatidylcholine Biosynthesis Triggers Apoptosis in Chinese Hamster Ovary Cells

  Zheng Cui;Martin Houweling;Ming H. Chen;Michel Record

  269
  Citations

• Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig.

  Ama Diagne;Josette Fauvel;Michel Record;Hugues Chap

  251
  Citations

• Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets.

  Pascal Grondin;Monique Plantavid;Claire Sultan;Monique Breton

  237
  Citations

• Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome.

  T. Lhermusier;H. Chap;B. Payrastre

  229
  Citations

• Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. Possible involvement of a platelet lipase.

  Gérard Mauco;Hugues Chap;Marie-Françoise Simon;Louis Douste-Blazy

  214
  Citations

• Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

  Frédérique Gaits;Olivier Fourcade;François Le Balle;Geneviève Gueguen

  213
  Citations

• Phosphatidylinositol 3,4,5-Trisphosphate-dependent Stimulation of Phospholipase C-γ2 Is an Early Key Event in FcγRIIA-mediated Activation of Human Platelets *

  Marie-Pierre Gratacap;Bernard Payrastre;Cécile Viala;Gérard Mauco

  201
  Citations

• Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation.

  Bertrand Perret;Hugues J. Chap;Louis Douste-Blazy

  196
  Citations

• A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

  Armelle Yart;Muriel Laffargue;Patrick Mayeux;Stany Chretien

  192
  Citations

• Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation.

  Geneviève Gueguen;Bernadette Gaigé;Jean-Michel Grévy;Pierre Rogalle

  174
  Citations

• An interaction between apo C-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients.

  Josette Fauvel;Eric Bonnet;Jean-Bernard Ruidavets;Jean Ferrieres

  165
  Citations

• Pre-beta HDL: structure and metabolism.

  Alain Barrans;Beatrice Jaspard;Ronald Barbaras;Hugues Chap

  164
  Citations

• Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol

  G. Mauco;H. Chap;L. Douste-Blazy

  159
  Citations