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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
35834
World Ranking
1448
National Ranking
94

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Bernhard Brüne is affiliated with Goethe University Frankfurt in Germany. Their research spans multiple domains within biochemistry, genetics, molecular biology, medicine, immunology, and microbiology. The work focuses particularly on the intersection of immune function, cancer biology, and molecular mechanisms influencing disease progression.

The scientist has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with 110 publications. They have also worked on 82 publications related to medicine and 66 publications within immunology and microbiology. Key subfields of study include immunology, molecular biology, cancer research, oncology, and pulmonary and respiratory medicine.

The main research topics covered by Bernhard Brüne include:

  • Immune cells in cancer
  • Immune cell function and interaction
  • Cancer, hypoxia, and metabolism
  • Cancer, lipids, and metabolism
  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Phagocytosis and immune regulation

Frequent co-authors collaborating with Bernhard Brüne have included Andreas Weigert, Dominik C. Fuhrmann, Tobias Schmid, Dmitry Namgaladze, and Rebekka Bauer, with collaborative publication counts ranging from 10 to 43 papers with these researchers.

Bernhard Brüne has published in a variety of academic journals, with notable recurring venues including:

  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Biological Chemistry
  • Redox Biology
  • Frontiers in Pharmacology

Some of the recent publications featuring contributions associated with Bernhard Brüne include:

  • "Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis" (2020, Redox Biology)
  • "Ferroptosis in health and disease" (2024, Redox Biology)
  • "Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer" (2020, Science Advances)
  • "Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer" (2020, Journal of Clinical Investigation)
  • "The proteogenomic subtypes of acute myeloid leukemia" (2022, Cancer Cell)

Best Publications

  • Nrf2, the Master Regulator of Anti-Oxidative Responses

    Sandra Vomund;Anne Schäfer;Michael J Parnham;Bernhard Brüne;Bernhard Brüne

  • Nitric oxide and its role in apoptosis

    Bernhard Brüne;Andreas von Knethen;Katrin B Sandau

  • p53 expression in nitric oxide-induced apoptosis

    Udo K. Meßmer;Maria Ankarcrona;Pierluigi Nicotera;Bernhard Brüne

  • Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

    Eric Metzen;Jie Zhou;Wolfgang Jelkmann;Joachim Fandrey

  • Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents.

    B Brüne;E G Lapetina

  • Nitric oxide: NO apoptosis or turning it ON?

    Bernhard Brüne

  • Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase.

    Susanne Mohr;Hazem Hallak;Alexander de Boitte;Eduardo G. Lapetina

  • Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways.

    Udo K Messmer;Bernhard Brüne

  • Redox control of inflammation in macrophages.

    Bernhard Brüne;Nathalie Dehne;Nina Grossmann;Michaela Jung

  • Nitric oxide (NO): an effector of apoptosis.

    Brüne B;von Knethen A;Sandau Kb

  • Accumulation of HIF-1α under the influence of nitric oxide

    Katrin Britta Sandau;Joachim Fandrey;Bernhard Brüne

  • Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

    L Molina y Vedia;B McDonald;B Reep;B Brüne

  • Posttranslational Modification of Glyceraldehyde-3-phosphate Dehydrogenase by S-Nitrosylation and Subsequent NADH Attachment

    Susanne Mohr;Jonathan S. Stamler;Bernhard Brüne

  • PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation

    Jie Zhou;Tobias Schmid;Ronald Frank;Bernhard Brüne

  • Bcl-2 protects macrophages from nitric oxide-induced apoptosis

    Udo K. Meβmer;John C. Reed;Bernhard Brüne

  • Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide

    Susanne Mohr;Birgit Zech;Eduardo G. Lapetina;Bernhard Brüne

  • Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide

    Katrin B. Sandau;Jie Zhou;Thomas Kietzmann;Bernhard Brüne

  • Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.

    U K Messmer;E G Lapetina;B Brüne

  • Spermine prevents endonuclease activation and apoptosis in thymocytes

    Bernhard Brüne;Pia Hartzell;Pierluigi Nicotera;Sten Orrenius

  • S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

    Benjamin Weichand;Rüdiger Popp;Sarah Dziumbla;Javier Mora

Frequent Co-Authors

Josef Pfeilschifter
Josef Pfeilschifter Goethe University Frankfurt
Eduardo G. Lapetina
Eduardo G. Lapetina Case Western Reserve University
Joachim Fandrey
Joachim Fandrey University of Duisburg-Essen
Gerd Geisslinger
Gerd Geisslinger Goethe University Frankfurt
Volker Ullrich
Volker Ullrich University of Konstanz
Rolf Backofen
Rolf Backofen University of Freiburg
Gisa Tiegs
Gisa Tiegs University of Erlangen-Nuremberg
John C. Reed
John C. Reed Johnson & Johnson (United States)
Giacinto Bagetta
Giacinto Bagetta University of Calabria
Ingrid Fleming
Ingrid Fleming Goethe University Frankfurt

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