World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
54
Citations
14996
World Ranking
2307
National Ranking
183

Research.com Recognitions

  • 2002 - Fellow of the Royal Society, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

David Ish-Horowicz is affiliated with University College London in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research primarily spans molecular biology, with additional work touching on cardiology, cardiovascular medicine, plant science, and cellular and molecular neuroscience.

The scientist's work covers a range of topics within molecular and developmental biology, including RNA research and splicing, gene regulation, genomics, chromatin dynamics, nuclear structure and function, cardiomyopathy and myosin studies, plant molecular biology, as well as neurobiology and insect physiology.

Key publication venues for Ish-Horowicz include:

  • Biology Open
  • eLife
  • The Journal of Cell Biology
  • RNA
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers authored or co-authored by Ish-Horowicz feature studies on neural stem cell growth, synapse formation, and mRNA stability:

  • "Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability" (2020, eLife)
  • "Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation" (2020, The Journal of Cell Biology)
  • "Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation" (2020, Biology Open)
  • "Greb1 is required for axial elongation and segmentation in vertebrate embryos" (2020, Biology Open)
  • "Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the Drosophila larval brain" (2023, RNA)

Their collaborative network includes frequent co-authors such as Ilan Davis, Aino I. Järvelin, Tamsin J. Samuels, Mary Kay Thompson, and Arianna Ceccarelli.

David Ish-Horowicz has been recognized through election as a Fellow of the Royal Society, United Kingdom in 2002 and is also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Expression of a Delta homologue in prospective neurons in the chick

    Domingos Henrique;Julie Adam;Anna Myat;Ajay Chitnis

  • Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis

    Isabel Palmeirim;Domingos Henrique;David Ish-Horowicz;Olivier Pourquié

  • Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.

    Ajay Chitnis;Domingos Henrique;Julian Lewis;David Ish-Horowicz

  • Notch signalling and the synchronization of the somite segmentation clock.

    Yun-Jin Jiang;Birgit L. Aerne;Lucy Smithers;Catherine Haddon

  • Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

    Paroush Z;Finley Rl;Kidd T;Wainwright Sm

  • Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina.

    Domingos Henrique;Estelle Hirsinger;Julie Adam;Isabelle Le Roux

  • A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis

    Anna Myat;Domingos Henrique;David Ish-Horowicz;Julian Lewis

  • Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.

    Katsuto Hozumi;Naoko Negishi;Daisuke Suzuki;Natsumi Abe

  • Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm

    C. Jouve;I. Palmeirim;D. Henrique;J. Beckers

  • Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis

    Carolina Mailhos;Ute Modlich;Julian Lewis;Adrian Harris

  • Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis.

    Simon L. Bullock;David Ish-Horowicz

  • Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development.

    J. Adam;A. Myat;I. Le Roux;M. Eddison

  • Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed

    Gerardo Jiménez;Ze’ev Paroush;David Ish-Horowicz

  • Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells

    Gerard F. Hoyne;Isabelle Le Roux;Marta Corsin-Jimenez;Karen Tan

  • Extrachromosomal circular copies of the eukaryotic transposable element copia in cultured Drosophila cells

    Andrew J. Flavell;David Ish-Horowicz

  • The Groucho/TLE/Grg family of transcriptional co-repressors

    Barbara H Jennings;David Ish-Horowicz

  • Apical localization of pair-rule transcripts requires 3' sequences and limits protein diffusion in the Drosophila blastoderm embryo.

    Ilan Davis;David Ish-Horowicz

  • Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling.

    Aixa V. Morales;Yuko Yasuda;David Ish-Horowicz

  • Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor

    Barbara H. Jennings;Laura M. Pickles;S. Mark Wainwright;S. Mark Roe

  • Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation.

    E. Hirsinger;P. Malapert;J. Dubrulle;M.C. Delfini

Frequent Co-Authors

Domingos Henrique
Domingos Henrique University of Lisbon
Julian Lewis
Julian Lewis Cancer Research UK London Research Institute
Tzumin Lee
Tzumin Lee University of Michigan–Ann Arbor
Andrew J. Flavell
Andrew J. Flavell University of Dundee
Olivier Pourquié
Olivier Pourquié Brigham and Women's Hospital
Shoukat Dedhar
Shoukat Dedhar University of British Columbia
Giampietro Schiavo
Giampietro Schiavo University College London
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Scott Waddell
Scott Waddell University of Oxford
Michael John Owen
Michael John Owen Cardiff University

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