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Biology and Biochemistry

D-Index
54
Citations
14159
World Ranking
15433
National Ranking
1088

Overview

Achim Gossler is affiliated with Hannover Medical School in Germany. Their research is concentrated primarily in the fields of biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, genetics, cell biology, hepatology, and surgery.

The scientific work of Achim Gossler spans multiple topics related to developmental and genetic processes. The main areas of research include congenital heart defects, developmental biology and gene regulation, genetic and kidney cyst diseases, genetics and neurodevelopmental disorders, protist diversity and phylogeny, pluripotent stem cells research, and renal and related cancers.

Some of the recent research papers authored by Achim Gossler are:

  • "Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates," 2021, published in Nature Genetics
  • "The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development," 2020, published in Development
  • "The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus," 2021, published in Scientific Reports
  • "Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs," 2024, published in Immunity
  • "CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans," 2025, published in The American Journal of Human Genetics

Frequent co-authors collaborating with Achim Gossler include:

  • Tim Ott
  • Anja Beckers
  • Martin Blum
  • Karin Schuster-Gossler
  • Karsten Boldt

Publication venues where Achim Gossler has frequently contributed include:

  • Nature Genetics
  • Development
  • Scientific Reports
  • Immunity
  • The American Journal of Human Genetics

The diverse range of fields and topics covered indicates a research focus on genetic and developmental mechanisms, particularly those influencing left-right asymmetry, ciliary function, and cellular signaling pathways related to organ development and immune function.

Best Publications

  • The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

    Rui Benedito;Rui Benedito;Cristina Roca;Inga Sörensen;Susanne Adams;Susanne Adams

  • Wnt3a plays a major role in the segmentation clock controlling somitogenesis

    Alexander Aulehla;Christian Wehrle;Beate Brand-Saberi;Rolf Kemler

  • Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

    Achim Gossler;Alexandra L. Joyner;Alexandra L. Joyner;Janet Rossant;Janet Rossant;William C. Skarnes

  • Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

    B. Bettenhausen;M. Hrabe de Angelis;D. Simon;J.L. Guenet

  • Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development.

    Claire E. Lindsell;Jim Boulter;Guy diSibio;Achim Gossler

  • DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

    Inga Sörensen;Ralf H. Adams;Ralf H. Adams;Achim Gossler

  • Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm

    C. Jouve;I. Palmeirim;D. Henrique;J. Beckers

  • Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos

    Dietmar Vestweber;Achim Gossler;Klaus Boller;Rolf Kemler

  • Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron

    Hui-Teng Cheng;Mijin Kim;M. Todd Valerius;Kameswaran Surendran

  • Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.

    Diogo S. Castro;Dorota Skowronska-Krawczyk;Dorota Skowronska-Krawczyk;Olivier Armant;Olivier Armant;Ian J. Donaldson

  • Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants

    Karin Schuster-Gossler;Ralf Cordes;Achim Gossler

  • The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear

    Amy E. Kiernan;Ralf Cordes;Raphael Kopan;Achim Gossler

  • Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.

    Alastair Morrison;Christine Hodgetts;Achim Gossler;Martin Hrabé de Angelis

  • Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse

    Ivén del Barco Barrantes;Andrew J. Elia;Kurt Wünsch;Martin Hrabe De Angelis

  • Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons.

    Rumiko Mizuguchi;Sonja Kriks;Ralf Cordes;Achim Gossler

  • A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas.

    Steffen Zender;Irina Nickeleit;Torsten Wuestefeld;Inga Sörensen

  • WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

    Michael Hofmann;Karin Schuster-Gossler;Masami Watabe-Rudolph;Alexander Aulehla

  • Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice.

    Petra Bilinski;Derry Roopenian;Achim Gossler

  • Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms

    Thorsten B. Feyerabend;Grzegorz Terszowski;Annette Tietz;Carmen Blum

  • Expression of Notch pathway components in fetal and adult mouse small intestine.

    Natalia Schröder;Achim Gossler

Frequent Co-Authors

Janet Rossant
Janet Rossant University of Toronto
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society
Johannes Beckers
Johannes Beckers Technical University of Munich
marius ueffing
marius ueffing University of Tübingen
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Martin Blum
Martin Blum University of Hohenheim
Andreas Kispert
Andreas Kispert Hannover Medical School
Domingos Henrique
Domingos Henrique University of Lisbon
Bernhard G. Herrmann
Bernhard G. Herrmann Max Planck Society
Ralf H. Adams
Ralf H. Adams Max Planck Society

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