World's Best Scientists 2026 revealed!

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Molecular Biology

D-Index
42
Citations
5791
World Ranking
3036
National Ranking
122

Overview

Brice Felden was affiliated with the University of Rennes in France and contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research primarily focused on microbial regulation and pathogenesis, especially concerning Staphylococcus species and RNA-mediated bacterial processes.

The main fields of study associated with Felden's work included biochemistry, genetics and molecular biology, and medicine. Within these broad areas, key subfields of study involved molecular biology, genetics, infectious diseases, ecology, and molecular medicine. This multidisciplinary approach reflected the complex biological interactions Felden investigated.

Felden's research covered several main topics, including antimicrobial resistance in Staphylococcus, bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, bacteriophages and microbial interactions, antibiotic resistance in bacteria, corrosion behavior and inhibition, and bacterial biofilms and quorum sensing.

Their recent publications demonstrated ongoing engagement with microbial RNA regulation and bacterial pathogenesis. Notable papers included:

  • Diversity and Versatility in Small RNA-Mediated Regulation in Bacterial Pathogens, 2021, Frontiers in Microbiology
  • sRNA-controlled iron sparing response in Staphylococci, 2022, Nucleic Acids Research
  • RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus, 2021, Nature Microbiology
  • Cross-Regulations between Bacterial Toxin-Antitoxin Systems: Evidence of an Interconnected Regulatory Network?, 2020, Trends in Microbiology
  • Galleria mellonella Larvae as an Infection Model to Investigate sRNA-Mediated Pathogenesis in Staphylococcus aureus, 2021, Frontiers in Cellular and Infection Microbiology

Throughout their career, Felden published frequently in venues such as Frontiers in Microbiology, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, mSystems, and Toxins.

The scientist worked collaboratively with several frequent co-authors, including Vincent Cattoir, Marie-Laure Pinel-Marie, Wenfeng Liu, Philippe Bouloc, and Yoann Augagneur. These collaborations likely supported and enriched the multidisciplinary aspects of their research.

Best Publications

  • Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains

    Christophe Pichon;Brice Felden

  • Presence and location of modified nucleotides in Escherichia coli tmRNA: structural mimicry with tRNA acceptor branches

    Brice Felden;Kyoko Hanawa;John F. Atkins;Hyouta Himeno

  • Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism

    Chantal Bohn;Candice Rigoulay;Svetlana Chabelskaya;Cynthia Mira Sharma

  • A Staphylococcus aureus small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule.

    Svetlana Chabelskaya;Olivier Gaillot;Brice Felden

  • Ribosome Rescue by tmRNA Requires Truncated mRNAs

    Natalia Ivanova;Michael Y. Pavlov;Brice Felden;Måns Ehrenberg

  • The Staphylococcus aureus RNome and its commitment to virulence.

    Brice Felden;François Vandenesch;Philippe Bouloc;Pascale Romby

  • Aminoacylated tmRNA from Escherichia coli interacts with prokaryotic elongation factor Tu.

    Joëlle Rudinger-Thirion;Richard Giegé;Brice Felden

  • Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB

    Sascha Gutmann;Peter W. Haebel;Laurent Metzinger;Markus Sutter

  • A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide

    Nour Sayed;Ambre Jousselin;Brice Felden

  • On the facultative requirement of the bacterial RNA chaperone, Hfq

    Ambre Jousselin;Laurent Metzinger;Brice Felden

  • Solution structure of the 3'-end of brome mosaic virus genomic RNAs. Conformational mimicry with canonical tRNAs.

    B. Felden;C. Florentz;R. Giegé;E. Westhof

  • Functional and structural analysis of a pseudoknot upstream of the tag-encoded sequence in E. coli tmRNA.

    Nobukazu Nameki;Brice Felden;John F. Atkins;Raymond F. Gesteland

  • Prediction of antisense oligonucleotide efficacy by in vitro methods

    Olga Matveeva;Brice Felden;Alexander Tsodikov;Joseph Johnston

  • Small RNA gene identification and mRNA target predictions in bacteria

    Christophe Pichon;Brice Felden

  • Dual Toxic-Peptide-Coding Staphylococcus aureus RNA under Antisense Regulation Targets Host Cells and Bacterial Rivals Unequally

    Marie-Laure Pinel-Marie;Régine Brielle;Brice Felden

  • Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module.

    Nour Sayed;Sylvie Nonin-Lecomte;Sylvie Nonin-Lecomte;Stéphane Réty;Stéphane Réty;Brice Felden

  • Curli synthesis and biofilm formation in enteric bacteria are controlled by a dynamic small RNA module made up of a pseudoknot assisted by an RNA chaperone

    Valérie Bordeau;Brice Felden

  • A non-coding function of TYRP1 mRNA promotes melanoma growth

    David Gilot;Mélodie Migault;Laura Bachelot;Fabrice Journé

  • Pre-binding of small protein B to a stalled ribosome triggers trans-translation.

    Marc Hallier;Natalia Ivanova;Armelle Rametti;Michael Pavlov

  • Linking bacterial type I toxins with their actions.

    Régine Brielle;Marie-Laure Pinel-Marie;Brice Felden

Frequent Co-Authors

Vincent Cattoir
Vincent Cattoir University of Rennes
John F. Atkins
John F. Atkins University College Cork
Raymond F. Gesteland
Raymond F. Gesteland University of Utah
Joachim Frank
Joachim Frank Columbia University
Daniel Thomas
Daniel Thomas University of Rennes
Richard Giegé
Richard Giegé Centre national de la recherche scientifique, CNRS
Måns Ehrenberg
Måns Ehrenberg Uppsala University
Jörg Vogel
Jörg Vogel University of Würzburg
Cynthia M. Sharma
Cynthia M. Sharma University of Würzburg
Eric Jacquet
Eric Jacquet Institut de Chimie des Substances Naturelles

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