World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
26726
World Ranking
13511
National Ranking
466

Overview

Arnim Pause is affiliated with McGill University in Canada and primarily engages in research within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research encompasses several subfields, notably Molecular Biology, Epidemiology, Cell Biology, Physiology, and Pulmonary and Respiratory Medicine.

The scientist's work covers diverse topics, including:

  • Autophagy in Disease and Therapy
  • Metabolism, Diabetes, and Cancer
  • Renal cell carcinoma treatment
  • Liver Disease Diagnosis and Treatment
  • Endoplasmic Reticulum Stress and Disease
  • Renal and related cancers
  • Ubiquitin and proteasome pathways

Frequent co-authors collaborating with Arnim Pause include:

  • Leeanna El-Houjeiri
  • Hyeonju Jeong
  • Peter M. Siegel
  • Mathieu Paquette
  • Marco Biondini

The scientist's recent publications demonstrate an emphasis on cellular signaling pathways and molecular mechanisms, with the following papers among their contributions:

  • AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3 (2021, Autophagy)
  • Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways (2021, Frontiers in Cell and Developmental Biology)
  • The dead phosphatases society: a review of the emerging roles of pseudophosphatases (2020, FEBS Journal)
  • HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin (2022, Oncogene)
  • Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes (2021, iScience)

Publication venues where Arnim Pause has frequently contributed include Oncogene, bioRxiv (Cold Spring Harbor Laboratory), Autophagy, Frontiers in Cell and Developmental Biology, and FEBS Journal.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

    Arnim Pause;Graham J. Belsham;Anne Claude Gingras;Olivier Donzé

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.

    S. Mader;Han Lee;A. Pause;N. Sonenberg

  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

    Tai-An Lin;Xianming Kong;Timothy A. J. Haystead;Arnim Pause

  • Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF‐4A.

    A. Pause;N. Sonenberg

  • mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

    Masahiro Morita;Simon Pierre Gravel;Valérie Chénard;Kristina Sikström

  • Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

    A. Haghighat;S. Mader;A. Pause;N. Sonenberg

  • Inhibition of transcription elongation by the VHL tumor suppressor protein

    D. R. Duan;A. Pause;W. H. Burgess;T. Aso

  • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

    Arnim Pause;Stephen Lee;Robert A. Worrell;David Y. T. Chen

  • Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

    Kazuhiro Iwai;Koji Yamanaka;Takumi Kamura;Nagahiro Minato

  • The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

    Yuri V. Svitkin;Arnim Pause;Ashkan Haghighat;Stéphane Pyronnet

  • Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

    Arnim Pause;Nathalie Méthot;Yuri Svitkin;William C. Merrick

  • AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.

    Rebecca C Rabinovitch;Bozena Samborska;Brandon Faubert;Eric H Ma

  • The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.

    A Pause;N Méthot;N Sonenberg

  • An oxygen-regulated switch in the protein synthesis machinery

    James Uniacke;Chet E. Holterman;Gabriel Lachance;Aleksandra Franovic

  • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

    Arnim Pause;Stephen Lee;Kim M. Lonergan;Richard D. Klausner

  • Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.

    Anne-Claude Gingras;Yuri Svitkin;Graham J. Belsham;Arnim Pause

  • The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.

    Rousseau D;Gingras Ac;Pause A;Sonenberg N

  • mTOR Pathways in Cancer and Autophagy.

    Mathieu Paquette;Leeanna El-Houjeiri;Arnim Pause

Frequent Co-Authors

Nahum Sonenberg
Nahum Sonenberg McGill University
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Russell G. Jones
Russell G. Jones McGill University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Yuri V. Svitkin
Yuri V. Svitkin McGill University
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Graham J. Belsham
Graham J. Belsham University of Copenhagen
Yee-Joo Tan
Yee-Joo Tan National University of Singapore
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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