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Biology and Biochemistry
UK
2026

D-Index & Metrics

Chemistry

D-Index
103
Citations
47362
World Ranking
1095
National Ranking
57

Biology and Biochemistry

D-Index
115
Citations
54145
World Ranking
781
National Ranking
43

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Andrew P. Halestrap is affiliated with the University of Bristol in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to immunology and microbiology. Their work explores detailed molecular mechanisms in cellular biology, particularly related to mitochondrial function and immune responses.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Subfields covered in their research include:

  • Molecular Biology
  • Immunology
  • Aging
  • Biophysics
  • Pathology and Forensic Medicine

The core topics addressed in their publications are:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Genetics, Aging, and Longevity in Model Organisms
  • IL-33, ST2, and ILC Pathways
  • Immune Cell Function and Interaction
  • Electron Spin Resonance Studies
  • T-cell and B-cell Immunology

Notable recent papers include:

  • Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions, 2023, Cell Death and Differentiation
  • Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health, 2021, Journal of Cell Science
  • Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors, 2021, JCI Insight
  • Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia, 2020, PLoS ONE
  • The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation, 2020, Journal of Biological Chemistry

Andrew P. Halestrap frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Death and Differentiation
  • Journal of Cell Science
  • JCI Insight
  • PLoS ONE

Frequent collaborators in their research include:

  • Chris Neal
  • Gonçalo C. Pereira
  • Amber Knapp-Wilson
  • Emma Buzzard
  • A. Richardson

Andrew P. Halestrap has been recognized as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

    Mark R. Owen;Elena Doran;Andrew P. Halestrap

  • Role of calcium ions in regulation of mammalian intramitochondrial metabolism

    J. G. McCormack;A. P. Halestrap;R. M. Denton

  • The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

    Andrew P. Halestrap;Nigel T. Price

  • Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection

    Andrew P Halestrap;Samantha J Clarke;Sabzali A Javadov

  • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

    Andrew P. Halestrap;David Meredith

  • What is the mitochondrial permeability transition pore

    Andrew P. Halestrap

  • Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

    A P Halestrap;A M Davidson

  • Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion.

    E J Griffiths;A P Halestrap

  • The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

    Mohammed S. Ullah;Andrew J. Davies;Andrew P. Halestrap

  • The permeability transition pore complex: another view.

    Andrew P Halestrap;Gavin P McStay;Samantha J Clarke

  • Transport of lactate and other monocarboxylates across mammalian plasma membranes

    R. C. Poole;A. P. Halestrap

  • The SLC16 gene family – Structure, role and regulation in health and disease☆

    Andrew P Halestrap

  • The monocarboxylate transporter family-Structure and functional characterization

    Andrew P. Halestrap

  • Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

    Edith C.H. Friesema;Sumita Ganguly;Amal Abdalla;Jocelyn E.Manning Fox

  • CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.

    P Kirk;Marieangela C Wilson;C Heddle;MH Brown

  • The monocarboxylate transporter family—Role and regulation

    Andrew P. Halestrap;Marieangela C. Wilson

  • Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

    Edith C. H. Friesema;Annette Grueters;Heike Biebermann;Heiko Krude

  • Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase.

    Andrew P. Halestrap;Kuei-Ying Woodfield;Cathal P. Connern

  • Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

    Elinor J. Griffiths;Andrew P. Halestrap

  • Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

    Andrew P. Halestrap;Paul M. Kerr;Sabzali Javadov;K.-Y. Woodfield

Frequent Co-Authors

Sabzali Javadov
Sabzali Javadov University of Puerto Rico
David Meredith
David Meredith Brigham and Women's Hospital
Arend Bonen
Arend Bonen University of Guelph
Richard M. Denton
Richard M. Denton University of Bristol
Guy A. Rutter
Guy A. Rutter Imperial College London
Gianni D. Angelini
Gianni D. Angelini University of Bristol
Andrew P. Thomas
Andrew P. Thomas Rutgers, The State University of New Jersey
Linda H. Bergersen
Linda H. Bergersen University of Oslo
David G. Nicholls
David G. Nicholls Buck Institute for Research on Aging
Ole Petter Ottersen
Ole Petter Ottersen University of Oslo

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