D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 98 Citations 40,799 185 World Ranking 763 National Ranking 50

Research.com Recognitions

Awards & Achievements

Fellow of The Academy of Medical Sciences, United Kingdom

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Andrew P. Halestrap spends much of his time researching Biochemistry, Mitochondrion, Mitochondrial permeability transition pore, Inner mitochondrial membrane and Cyclosporin a. Andrew P. Halestrap has included themes like Apoptosis, Programmed cell death and Metabolism in his Mitochondrion study. His Mitochondrial permeability transition pore study combines topics in areas such as Biophysics, Cell biology, Mitochondrial membrane transport protein and Voltage-dependent anion channel.

His study on Inner mitochondrial membrane is mostly dedicated to connecting different topics, such as Adenine nucleotide. His Cyclosporin a study combines topics from a wide range of disciplines, such as Oxidative stress, Anesthesia, Reperfusion injury, Ischemia and Pharmacology. His research in Monocarboxylate transporter intersects with topics in Endocrinology, Internal medicine, Skeletal muscle, Glycolysis and Molecular biology.

His most cited work include:

  • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain (1476 citations)
  • Role of calcium ions in regulation of mammalian intramitochondrial metabolism (1158 citations)
  • The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation (1084 citations)

What are the main themes of his work throughout his whole career to date?

Andrew P. Halestrap mainly investigates Biochemistry, Mitochondrion, Mitochondrial permeability transition pore, Cell biology and Internal medicine. His Biochemistry study is mostly concerned with Lactate transport, Monocarboxylate transporter, Pyruvate transport, Pyruvate carboxylase and Pyruvate dehydrogenase complex. He is involved in the study of Mitochondrion that focuses on Inner mitochondrial membrane in particular.

His studies in Mitochondrial permeability transition pore integrate themes in fields like Cardioprotection, Biophysics, Mitochondrial membrane transport protein, Reperfusion injury and Cyclosporin a. His Cell biology research incorporates elements of Apoptosis and Oxidative phosphorylation. His Internal medicine research integrates issues from Endocrinology, Respiratory chain and Cardiology.

He most often published in these fields:

  • Biochemistry (50.90%)
  • Mitochondrion (35.02%)
  • Mitochondrial permeability transition pore (22.38%)

What were the highlights of his more recent work (between 2007-2021)?

  • Biochemistry (50.90%)
  • Mitochondrial permeability transition pore (22.38%)
  • Mitochondrion (35.02%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Biochemistry, Mitochondrial permeability transition pore, Mitochondrion, Biophysics and Reperfusion injury. Andrew P. Halestrap performs integrative Biochemistry and Basigin research in his work. The study incorporates disciplines such as Cardioprotection, Mitochondrial membrane transport protein, Inner mitochondrial membrane, Cyclosporin a and Ischemic preconditioning in addition to Mitochondrial permeability transition pore.

His work in Inner mitochondrial membrane tackles topics such as Adenine nucleotide which are related to areas like Intermembrane space and Cardiolipin. His research on Mitochondrion concerns the broader Cell biology. His research integrates issues of Reactive oxygen species, Pharmacology and Mitochondrial fission in his study of Reperfusion injury.

Between 2007 and 2021, his most popular works were:

  • What is the mitochondrial permeability transition pore (647 citations)
  • The monocarboxylate transporter family—Role and regulation (374 citations)
  • The monocarboxylate transporter family-Structure and functional characterization (363 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Biochemistry

Biochemistry, Mitochondrion, Mitochondrial permeability transition pore, Cell biology and Reperfusion injury are his primary areas of study. His research in the fields of Mitochondrial membrane transport protein, Cytochrome c and Mitochondrial apoptosis-induced channel overlaps with other disciplines such as Apoptosome. As a member of one scientific family, he mostly works in the field of Mitochondrial permeability transition pore, focusing on Biophysics and, on occasion, Cyclophilin.

His Cell biology study incorporates themes from Transport activity, Uniporter and Ion channel. His study in Reperfusion injury is interdisciplinary in nature, drawing from both Cyclosporin a, Cardioprotection and Molecular biology. His Inner mitochondrial membrane study integrates concerns from other disciplines, such as Glycolysis and Adenine nucleotide.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen;Elena Doran;Andrew P. Halestrap.
Biochemical Journal (2000)

1971 Citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

J. G. McCormack;A. P. Halestrap;R. M. Denton.
Physiological Reviews (1990)

1518 Citations

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection

Andrew P Halestrap;Samantha J Clarke;Sabzali A Javadov.
Cardiovascular Research (2004)

1439 Citations

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Andrew P. Halestrap;Nigel T. Price.
Biochemical Journal (1999)

1404 Citations

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

Andrew P. Halestrap;David Meredith.
Pflügers Archiv: European Journal of Physiology (2004)

1048 Citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

A P Halestrap;A M Davidson.
Biochemical Journal (1990)

1027 Citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion.

E J Griffiths;A P Halestrap.
Biochemical Journal (1995)

1019 Citations

What is the mitochondrial permeability transition pore

Andrew P. Halestrap.
Journal of Molecular and Cellular Cardiology (2009)

1005 Citations

The permeability transition pore complex: another view.

Andrew P Halestrap;Gavin P McStay;Samantha J Clarke.
Biochimie (2002)

886 Citations

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Mohammed S. Ullah;Andrew J. Davies;Andrew P. Halestrap.
Journal of Biological Chemistry (2006)

825 Citations

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