What is he best known for?
The fields of study he is best known for:
- Enzyme
- Metabolism
- Biochemistry
His primary scientific interests are in Biochemistry, Pyruvate dehydrogenase complex, Pyruvate carboxylase, Pyruvate dehydrogenase kinase and Internal medicine.
His Biochemistry study combines topics from a wide range of disciplines, such as Molecular biology and Insulin receptor.
His work deals with themes such as Dehydrogenase, Branched-chain alpha-keto acid dehydrogenase complex and Mitochondrion, which intersect with Pyruvate dehydrogenase complex.
His Pyruvate carboxylase research is multidisciplinary, incorporating perspectives in Enzyme assay and Fatty acid synthesis.
His Pyruvate dehydrogenase kinase research includes elements of Pyruvate decarboxylation and Pyruvate dehydrogenase phosphatase.
His biological study spans a wide range of topics, including Endocrinology and Guanine nucleotide exchange factor.
His most cited work include:
- Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide. (320 citations)
- Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. (259 citations)
- Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells ACTIVATION OF PROTEIN KINASE B BY WORTMANNIN-SENSITIVE AND -INSENSITIVE MECHANISMS (226 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Biochemistry, Internal medicine, Endocrinology, Pyruvate dehydrogenase complex and Insulin.
Biochemistry is a component of his Pyruvate dehydrogenase kinase, Pyruvate dehydrogenase phosphatase, Pyruvate carboxylase, Oxoglutarate dehydrogenase complex and Branched-chain alpha-keto acid dehydrogenase complex studies.
His Fatty acid synthesis research extends to Internal medicine, which is thematically connected.
Richard M. Denton has researched Endocrinology in several fields, including Wortmannin and Glyceride.
His research in Pyruvate dehydrogenase complex intersects with topics in Dehydrogenase and Mitochondrion.
His studies in Insulin integrate themes in fields like Phosphorylation and Cell biology.
He most often published in these fields:
- Biochemistry (66.25%)
- Internal medicine (32.50%)
- Endocrinology (32.50%)
What were the highlights of his more recent work (between 1992-2020)?
- Biochemistry (66.25%)
- Insulin (25.63%)
- Cell biology (15.63%)
In recent papers he was focusing on the following fields of study:
Richard M. Denton spends much of his time researching Biochemistry, Insulin, Cell biology, Endocrinology and Internal medicine.
His Biochemistry study which covers Molecular biology that intersects with Dehydrogenase and NAD+ kinase.
His research integrates issues of Fatty acid synthesis, Wortmannin and Phosphorylation in his study of Insulin.
His Cell biology research incorporates elements of Oxidative phosphorylation and Cytosol.
His Endocrinology research is multidisciplinary, incorporating elements of Guanine nucleotide exchange factor and Kinase, Protein kinase A.
His research in Pyruvate dehydrogenase phosphatase focuses on subjects like Pyruvate decarboxylation, which are connected to PKM2.
Between 1992 and 2020, his most popular works were:
- Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells ACTIVATION OF PROTEIN KINASE B BY WORTMANNIN-SENSITIVE AND -INSENSITIVE MECHANISMS (226 citations)
- Mitochondrial Ca2+ Transport and the Role of Intramitochondrial Ca2+ in the Regulation of Energy Metabolism (121 citations)
- Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. (117 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Metabolism
- Amino acid
His scientific interests lie mostly in Biochemistry, Cell biology, Internal medicine, Endocrinology and ASK1.
Oxidative phosphorylation and Branched-chain alpha-keto acid dehydrogenase complex are subfields of Biochemistry in which his conducts study.
Richard M. Denton combines subjects such as Mitochondrial matrix and Cytosol with his study of Cell biology.
His Mitochondrial matrix research is multidisciplinary, relying on both Oxoglutarate dehydrogenase complex, Pyruvate dehydrogenase phosphatase, Calcium, Pyruvate dehydrogenase kinase and Citric acid cycle.
The concepts of his Internal medicine study are interwoven with issues in Protein kinase A and Phosphorylation.
His research on ASK1 also deals with topics like
- MAP kinase kinase kinase which connect with Cyclin-dependent kinase 9 and Akt/PKB signaling pathway,
- Insulin receptor together with Glycogen branching enzyme, Glycogenesis, Fatty acid synthesis, Glycogen and Pyruvate carboxylase.
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