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Biology and Biochemistry

D-Index
72
Citations
20360
World Ranking
6246
National Ranking
479

Overview

Richard M. Denton is affiliated with the University of Bristol in the United Kingdom. Their research primarily focuses on biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular biology and physiology as key subfields of study.

The scientist's work extensively covers topics such as mitochondrial function and pathology, adipose tissue and metabolism, and ATP synthase and ATPases research. These core areas reflect a detailed investigation into cellular energy processes and metabolic regulation.

Richard M. Denton's publication record includes recent papers in notable journals, including the following:

  • The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation, 2020, Journal of Biological Chemistry

Frequent collaborators in their research include:

  • Guy A. Rutter
  • James G. McCormack
  • Andrew P. Halestrap

Their work has been disseminated through the Journal of Biological Chemistry, which is a central venue for their scientific contributions.

Best Publications

  • Role of calcium ions in regulation of mammalian intramitochondrial metabolism

    J. G. McCormack;A. P. Halestrap;R. M. Denton

  • Regulation of mitochondrial dehydrogenases by calcium ions

    Richard M. Denton

  • Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.

    R M Denton;P J Randle;B R Martin

  • The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex.

    J G McCormack;R M Denton

  • Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.

    A L Kerbey;P J Randle;R H Cooper;S Whitehouse

  • Regulation of adipose-tissue pyruvate dehydrogenase by insulin and other hormones

    H. G. Coore;R. M. Denton;B. R. Martin;P. J. Randle

  • Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues.

    R M Denton;D A Richards;J G Chin

  • On the role of the calcium transport cycle in heart and other mammalian mitochondria

    Richard M. Denton;James G. McCormack

  • Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate (Short Communication)

    Andrew P. Halestrap;Richard M. Denton

  • INTEGRATING CYTOSOLIC CALCIUM SIGNALS INTO MITOCHONDRIAL METABOLIC RESPONSES

    Lawrence D. Robb‐Gaspers;Paul Burnett;Guy A. Rutter;Richard M. Denton

  • Interactions of metabolism and the physiological role of insulin.

    P J Randle;P B Garland;C N Hales;E A Newsholme

  • Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

    D Stansbie;R W Brownsey;M Crettaz;R M Denton

  • Ca2+ As a Second Messenger within Mitochondria of the Heart and other Tissues

    R M Denton;J G McCormack

  • Ca2+ transport by mammalian mitochondria and its role in hormone action.

    R. M. Denton;J. G. McCormack

  • Regulation of mammalian pyruvate dehydrogenase.

    Richard M. Denton;Philip J. Randle;Barbara J. Bridges;Ronald H. Cooper

  • Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells ACTIVATION OF PROTEIN KINASE B BY WORTMANNIN-SENSITIVE AND -INSENSITIVE MECHANISMS

    S. Kelly Moule;Gavin I. Welsh;Nigel J. Edgell;Emily J. Foulstone

  • Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria.

    R M Denton;J G McCormack;N J Edgell

  • The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart.

    J. R. Neely;R. M. Denton;P. J. England;P. J. Randle

  • Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

    P. J. Randle;P. J. England;R. M. Denton

  • Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

    Guy A. Rutter;Paul Burnett;Rosario Rizzuto;Marisa Brini

Frequent Co-Authors

James G. McCormack
James G. McCormack McC+R&D Consulting Ltd
Guy A. Rutter
Guy A. Rutter Imperial College London
Jeremy M. Tavaré
Jeremy M. Tavaré University of Bristol
Andrew P. Thomas
Andrew P. Thomas Rutgers, The State University of New Jersey
Graham J. Belsham
Graham J. Belsham University of Copenhagen
Christopher G. Proud
Christopher G. Proud University of Adelaide
Gavin I. Welsh
Gavin I. Welsh University of Bristol
Andrew P. Halestrap
Andrew P. Halestrap University of Bristol
Kenneth Siddle
Kenneth Siddle University of Cambridge
Rosario Rizzuto
Rosario Rizzuto University of Padua

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