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Genetics

D-Index
53
Citations
15971
World Ranking
3702
National Ranking
1600

Overview

Alea A. Mills is affiliated with Cold Spring Harbor Laboratory in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Within these broader disciplines, their subfields of study include Molecular Biology, Genetics, Oncology, Cancer Research, and Cognitive Neuroscience.

The scientific topics addressed by Mills' work focus largely on Epigenetics and DNA Methylation, Protein Degradation and Inhibitors, Genetics and Neurodevelopmental Disorders, Cancer-related Molecular Pathways, Cancer Genomics and Diagnostics, Genomics and Chromatin Dynamics, and Cancer-related Gene Regulation.

Mills has published extensively, including in venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Neuro-Oncology, the Journal of Cell Science, and Nature. Notable recent papers include:

  • p63-related signaling at a glance, 2020, Journal of Cell Science
  • BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network, 2022, Nature
  • Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4, 2020, Molecular Psychiatry
  • BRD4 Regulates Transcription Factor ΔNp63α to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas, 2021, Cancer Research
  • ΔNp63α in cancer: importance and therapeutic opportunities, 2022, Trends in Cell Biology

Frequent co-authors of Mills include Xueqin Sherine Sun, Matthew Fisher, Carlos Ballon, Seamus Balinth, and Caizhi Wu, reflecting ongoing collaborative research efforts.

Best Publications

  • p63 is a p53 homologue required for limb and epidermal morphogenesis.

    Alea A. Mills;Binhai Zheng;Xiao-Jing Wang;Hannes Vogel

  • Dicer is essential for mouse development.

    Emily Bernstein;Sang Yong Kim;Michelle A Carmell;Michelle A Carmell;Elizabeth P Murchison

  • p63 is the molecular switch for initiation of an epithelial stratification program

    Maranke I. Koster;Soeun Kim;Alea A. Mills;Francesco J. DeMayo

  • Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

    Kimberly L. Stark;Bin Xu;Anindya Bagchi;Wen Sung Lai

  • p63 regulates an adhesion programme and cell survival in epithelial cells.

    Danielle K. Carroll;Jason S. Carroll;Chee-Onn Leong;Fang Cheng;Fang Cheng

  • CHD5 Is a Tumor Suppressor at Human 1p36

    Anindya Bagchi;Cristian Papazoglu;Cristian Papazoglu;Ying Wu;Daniel Capurso

  • Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

    Guy Horev;Jacob Ellegood;Jason P. Lerch;Young-Eun E. Son

  • Perp Is a p63-Regulated Gene Essential for Epithelial Integrity

    Rebecca A. Ihrie;Michelle R. Marques;Bichchau T. Nguyen;Jennifer S. Horner

  • p63 deficiency activates a program of cellular senescence and leads to accelerated aging

    William M. Keyes;Ying Wu;Hannes Vogel;Xuecui Guo

  • The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.

    A.E. Eakin;A.A. Mills;G Harth;J.H. McKerrow

  • Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

    Alea A. Mills

  • p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.

    Johanna Laurikkala;Marja L. Mikkola;Martyn James;Mark Tummers

  • Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

    J Ellegood;E Anagnostou;B A Babineau;J N Crawley;J N Crawley

  • TAp63 induces senescence and suppresses tumorigenesis in vivo

    Xuecui Guo;William M. Keyes;Cristian Papazoglu;Cristian Papazoglu;Johannes Zuber

  • DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

    Jeffrey B. Kerr;Karla J. Hutt;Karla J. Hutt;Ewa M. Michalak;Ewa M. Michalak;Michele Cook

  • Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

    Yu Liu;Chong Chen;Chong Chen;Zhengmin Xu;Claudio Scuoppo

  • Role of p63 and basal cells in the prostate

    Takeshi Kurita;Roanna T. Medina;Alea A. Mills;Gerald R. Cunha

  • The quest for the 1p36 tumor suppressor.

    Anindya Bagchi;Alea A. Mills

  • ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis

    William M. Keyes;Matteo Pecoraro;Victoria Aranda;Emma Vernersson-Lindahl

  • Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi.

    Guenter Harth;Norma Andrews;Alea A. Mills;Juan C. Engel

Frequent Co-Authors

Allan Bradley
Allan Bradley University of Cambridge
Hannes Vogel
Hannes Vogel Stanford University
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Giorgio R. Merlo
Giorgio R. Merlo University of Turin
Eric J. Stanbridge
Eric J. Stanbridge University of California, Irvine
Gerald R. Cunha
Gerald R. Cunha University of California, San Francisco
Jacob Ellegood
Jacob Ellegood University of Toronto
Binhai Zheng
Binhai Zheng University of California, San Diego
Jacqueline N. Crawley
Jacqueline N. Crawley University of California, Davis
Dennis R. Roop
Dennis R. Roop University of Colorado Anschutz Medical Campus

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