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Biology and Biochemistry

D-Index
86
Citations
42444
World Ranking
2911
National Ranking
1492

Overview

Frank McKeon is affiliated with the University of Houston in the United States and has contributed extensively to the field of Medicine, with a focus on various specialized subfields.

Their research spans key areas such as Pulmonary and Respiratory Medicine, Surgery, Molecular Biology, Oncology, and Genetics. These fields reflect a broad range of biomedical interests and expertise centered on understanding disease mechanisms and therapeutic approaches.

Their scholarly output includes publications on topics such as Esophageal Cancer Research and Treatment, Cancer Cells and Metastasis, Neonatal Respiratory Health Research, Gastric Cancer Management and Outcomes, Helicobacter pylori-related gastroenterology studies, Tracheal and airway disorders, and Neuroblastoma Research and Treatments.

Frequent publication venues for their research include:

  • Cancer Research
  • Gastroenterology
  • UNC Libraries
  • Cellular and Molecular Gastroenterology and Hepatology
  • Medicinal Research Reviews

Notable recent papers by Frank McKeon are:

  • "Molecular targeting therapies for neuroblastoma: Progress and challenges" (2020, Medicinal Research Reviews)
  • "Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis" (2020, Cell)
  • "Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope" (2020, Cancer Letters)
  • "MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future" (2024, Pharmacological Reviews)
  • "Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment" (2022, Gut)

Frequent coauthors collaborating with Frank McKeon include:

  • Wa Xian
  • Matthew Vincent
  • Christopher P. Crum
  • Jaffer A. Ajani
  • Ashley Hoffman

Their work intersects multiple facets of cancer research and treatment, respiratory health, and molecular biology, indicating a multidisciplinary approach to addressing both cancer progression and pulmonary diseases.

Best Publications

  • p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

    Annie Yang;Ronen Schweitzer;Deqin Sun;Mourad Kaghad

  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

    Annie Yang;Mourad Kaghad;Yunmei Wang;Emily Gillett

  • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

    Mourad Kaghad;Helene Bonnet;Annie Yang;Laurent Creancier

  • p63 identifies keratinocyte stem cells

    Graziella Pellegrini;Elena Dellambra;Osvaldo Golisano;Enrica Martinelli

  • Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

    Hong Gang Wang;Nuzhat Pathan;Iryna M. Ethell;Stanislaw Krajewski

  • p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

    Annie Yang;Nancy Walker;Roderick Bronson;Mourad Kaghad

  • A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

    Y Lee;A Miron;R Drapkin;M R Nucci

  • p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

    Elsa Renee Flores;Kenneth Y Tsai;Denise Crowley;Denise Crowley;Shomit Sengupta;Shomit Sengupta

  • p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

    Makoto Senoo;Filipa Pinto;Christopher P. Crum;Frank McKeon

  • Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.

    Frank D. McKeon;Marc W. Kirschner;Daniel Caput

  • Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome.

    Jacopo Celli;Pascal Duijf;Ben C.J Hamel;Michael Bamshad

  • Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

    Rebecca Heald;Frank McKeon

  • p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development

    Sabina Signoretti;David Waltregny;James Dilks;Beth Isaac

  • Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

    Stephen S Taylor;Frank McKeon

  • On the shoulders of giants: p63, p73 and the rise of p53.

    Annie Yang;Mourad Kaghad;Daniel Caput;Frank McKeon

  • Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

    Futoshi Shibasaki;E. Roydon Price;David Milan;Frank McKeon

  • Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family

    Elsa Renee Flores;Shomit Sengupta;John B. Miller;Jamie J. Newman;Jamie J. Newman

  • p63 and p73: p53 mimics, menaces and more

    Annie Yang;Frank McKeon

  • An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.

    Christine D. Pozniak;Stevo Radinovic;Annie Yang;Frank McKeon

  • Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

    Rebecca Heald;Michael McLoughlin;Frank McKeon

Frequent Co-Authors

Christopher P. Crum
Christopher P. Crum Brigham and Women's Hospital
Jeffrey S. Hyams
Jeffrey S. Hyams University of Connecticut
Daniel Caput
Daniel Caput Novartis (United States)
Suzy V. Torti
Suzy V. Torti University of Connecticut Health Center
Volker Dötsch
Volker Dötsch Goethe University Frankfurt
Shiv Srivastava
Shiv Srivastava Uniformed Services University of the Health Sciences
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Roderick T. Bronson
Roderick T. Bronson Harvard University
Hans van Bokhoven
Hans van Bokhoven Radboud University
Han G. Brunner
Han G. Brunner Radboud University

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