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Akira Takeshita

Akira Takeshita

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Medicine
Japan
2023

D-Index & Metrics

Medicine

D-Index
123
Citations
49100
World Ranking
3379
National Ranking
61

Research.com Recognitions

  • 2023 - Research.com Medicine in Japan Leader Award

Overview

Akira Takeshita was affiliated with Kyushu University in Japan and contributed extensively to the field of Medicine, with a particular focus on Endocrinology, Diabetes and Metabolism. Their work spanned several subfields including Genetics, Surgery, Epidemiology, and Pulmonary and Respiratory Medicine.

Their research concentrated on key topics such as:

  • Pituitary Gland Disorders and Treatments
  • Adrenal and Paraganglionic Tumors
  • Growth Hormone and Insulin-like Growth Factors
  • Glioma Diagnosis and Treatment
  • Diabetes and associated disorders
  • Hormonal Regulation and Hypertension
  • Neuroendocrine Tumor Research Advances

Takeshita published a number of papers, including the following recent works:

  • Bi-glandular and persistent enterovirus infection and distinct changes of the pancreas in slowly progressive type 1 diabetes mellitus (2023, Scientific Reports)
  • Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease (2021, The Journal of Clinical Endocrinology & Metabolism)
  • GH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly (2021, Endocrine Journal)
  • A Case of Methimazole-Induced Acute Pancreatitis With an HLA Allele Causing Antithyroid Drug-Induced Agranulocytosis (2022, Journal of the Endocrine Society)
  • Immunohistochemistry or Molecular Analysis: Which Method Is Better for Subtyping Craniopharyngioma? (2020, Endocrine Pathology)

Their frequent coauthors included:

  • Keita Tatsushima
  • Yasuhiro Takeuchi
  • Noriaki Fukuhara
  • Hiroshi Nishioka
  • Shozo Yamada

Takeshita's work was regularly published in a select group of scientific venues, notably:

  • The Journal of Clinical Endocrinology & Metabolism
  • Internal Medicine
  • Scientific Reports
  • Endocrine Journal
  • Journal of the Endocrine Society

Best Publications

  • Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction.

    Tomomi Ide;Hiroyuki Tsutsui;Shunji Hayashidani;Dongchon Kang

  • Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium

    Tomomi Ide;Hiroyuki Tsutsui;Shintaro Kinugawa;Hideo Utsumi

  • Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.

    Kensuke Egashira;Yoshitaka Hirooka;Hisashi Kai;Masaru Sugimachi

  • Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms

    Kensuke Egashira;Tetsuzi Inou;Yoshitaka Hirooka;Akira Yamada

  • Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine

    Hiroaki Shimokawa;Akira Takeshita

  • Long-Term Inhibition of Rho-Kinase Suppresses Angiotensin II–Induced Cardiovascular Hypertrophy in Rats In Vivo Effect on Endothelial NAD(P)H Oxidase System

    Midoriko Higashi;Hiroaki Shimokawa;Tsuyoshi Hattori;Junko Hiroki

  • Suppression of Coronary Artery Spasm by the Rho-Kinase Inhibitor Fasudil in Patients With Vasospastic Angina

    Akihiro Masumoto;Masahiro Mohri;Hiroaki Shimokawa;Lemmy Urakami

  • Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes

    Nobuhiro Suematsu;Hiroyuki Tsutsui;Jing Wen;Dongchon Kang

  • Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

    Takahiro Nishida;Hiroaki Shimokawa;Keiji Oi;Hideki Tatewaki

  • Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.

    Kensuke Egashira;Tetsuzi Inou;Yoshitaka Hirooka;Hisashi Kai

  • Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

    Zhe Qi;Nobuhiko Atsuchi;Akira Ooshima;Akira Takeshita

  • Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium

    Tomomi Ide;Hiroyuki Tsutsui;Shintaro Kinugawa;Nobuhiro Suematsu

  • Fluvastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction

    Shunji Hayashidani;Hiroyuki Tsutsui;Tetsuya Shiomi;Nobuhiro Suematsu

  • Gene Transfer of Stromal Cell–Derived Factor-1α Enhances Ischemic Vasculogenesis and Angiogenesis via Vascular Endothelial Growth Factor/Endothelial Nitric Oxide Synthase–Related Pathway: Next-Generation Chemokine Therapy for Therapeutic Neovascularization

    Ken Ichi Hiasa;Minako Ishibashi;Kisho Ohtani;Shujiro Inoue

  • Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction.

    Shunji Hayashidani;Hiroyuki Tsutsui;Masaki Ikeuchi;Tetsuya Shiomi

  • Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans

    Akihiro Masumoto;Yoshitaka Hirooka;Hiroaki Shimokawa;Kiyoshi Hironaga

  • Greater Oxidative Stress in Healthy Young Men Compared With Premenopausal Women

    Tomomi Ide;Hiroyuki Tsutsui;Noriko Ohashi;Shunji Hayashidani

  • Increased Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive Rats

    Takuya Kishi;Yoshitaka Hirooka;Yoshikuni Kimura;Koji Ito

  • Angina pectoris caused by coronary microvascular spasm

    Masahiro Mohri;Masamichi Koyanagi;Kensuke Egashira;Hirofumi Tagawa

  • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

    Yoshihiro Fukumoto;T. Matoba;A. Ito;H. Tanaka

Frequent Co-Authors

Hiroaki Shimokawa
Hiroaki Shimokawa Tohoku University
Kensuke Egashira
Kensuke Egashira Kyushu University
Hiroyuki Tsutsui
Hiroyuki Tsutsui Kyushu University
Tsutomu Imaizumi
Tsutomu Imaizumi Kurume University
Kenji Sunagawa
Kenji Sunagawa Kyushu University
Hitonobu Tomoike
Hitonobu Tomoike National Cardiovascular Research Center
Yasuhiro Takeuchi
Yasuhiro Takeuchi University College London
Akira Ito
Akira Ito Nagoya University
Kozo Kaibuchi
Kozo Kaibuchi Nagoya University
Hideo Utsumi
Hideo Utsumi Kyushu University

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