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Medicine

D-Index
79
Citations
34926
World Ranking
17361
National Ranking
8697

Overview

Yves Boucher is affiliated with Harvard University in the United States and specializes in medicine, with a primary focus on oncology, immunology, physiology, biomedical engineering, and neurology. Their research spans a range of topics that include cancer immunotherapy and biomarkers, pancreatic and hepatic oncology research, immune cells in cancer, botulinum toxin and related neurological disorders, salivary gland disorders and functions, immunotherapy and immune responses, and nanoparticle-based drug delivery.

Boucher has contributed to scientific literature through multiple publications, including noteworthy recent papers such as:

  • "Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer" (2023) published in Clinical Cancer Research
  • "Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients" (2021) published in npj Precision Oncology

In addition to these, Boucher's work is frequently published in venues including:

  • Cancer Research
  • Journal of Oral Rehabilitation
  • Clinical Cancer Research
  • npj Precision Oncology
  • Advanced Therapeutics

Frequent co-authors collaborating with Boucher include:

  • Dan G. Duda
  • Jessica M. Posada
  • Ashwin S. Kumar
  • Rakesh K. Jain
  • Sonu Subudhi

Boucher's research explores interactions within the tumor microenvironment, focusing on immunosuppression and immune responses relevant to cancer treatment strategies. Their work engages with advanced therapeutic approaches such as nanoparticle-based drug delivery and chemoimmunotherapy nanogels, aiming at improving the efficacy of interventions in oncology.

Their studies also delve into the role of immune cells, such as regulatory T cells and dendritic cells, within cancer contexts, particularly in pancreatic and triple-negative breast cancers. This line of investigation supports understanding mechanisms underlying tumor immunology and potential therapeutic targets.

Best Publications

  • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

    Christopher G Willett;Yves Boucher;Emmanuelle di Tomaso;Dan G Duda

  • NORMALIZATION OF THE VASCULATURE FOR TREATMENT OF CANCER AND OTHER DISEASES

    Shom Goel;Dan G. Duda;Lei Xu;Lance L. Munn

  • Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

    Ricky T. Tong;Yves Boucher;Sergey V. Kozin;Frank Winkler

  • Lymphatic metastasis in the absence of functional intratumor lymphatics.

    Timothy P. Padera;Ananth Kadambi;Emmanuelle di Tomaso;Carla Mouta Carreira

  • Interstitial Pressure Gradients in Tissue-isolated and Subcutaneous Tumors: Implications for Therapy

    Yves Boucher;Laurence T. Baxter;Rakesh K. Jain

  • Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

    C. G. Lee;M. Heijn;E. Di Tomaso;G. Griffon-Etienne

  • Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.

    Edward Brown;Trevor McKee;Emmanuelle diTomaso;Alain Pluen

  • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

    Vikash P. Chauhan;John D. Martin;John D. Martin;Hao Liu;Delphine A. Lacorre

  • Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

    Triantafyllos Stylianopoulos;John D. Martin;John D. Martin;Vikash P. Chauhan;Saloni R. Jain;Saloni R. Jain

  • Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

    Alain Pluen;Yves Boucher;Saroja Ramanujan;Trevor D. McKee

  • Microvascular Pressure Is the Principal Driving Force for Interstitial Hypertension in Solid Tumors: Implications for Vascular Collapse

    Yves Boucher;Rakesh K. Jain

  • Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

    Benjamin Diop-Frimpong;Vikash P. Chauhan;Stephen Krane;Yves Boucher

  • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.

    Vikash P Chauhan;Triantafyllos Stylianopoulos;Yves Boucher;Rakesh K Jain

  • Mechanical compression drives cancer cells toward invasive phenotype.

    Janet M. Tse;Gang Cheng;James A. Tyrrell;Sarah A. Wilcox-Adelman

  • Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.

    Saroja Ramanujan;Alain Pluen;Trevor D. McKee;Trevor D. McKee;Edward B. Brown

  • LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.

    Carla Mouta Carreira;Selim M. Nasser;Emmanuelle di Tomaso;Timothy P. Padera

  • Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

    Christopher G. Willett;Dan G. Duda;Emmanuelle di Tomaso;Yves Boucher

  • Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows

    Fan Yuan;Hassan A. Salehi;Yves Boucher;Usha S. Vasthare

  • Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.

    Genevièeve Griffon-Etienne;Yves Boucher;Christian Brekken;Herman D. Suit

  • Stromal response to Hedgehog signaling restrains pancreatic cancer progression.

    John J. Lee;Rushika M. Perera;Huaijun Wang;Dai-Chen Wu

Frequent Co-Authors

Rakesh K. Jain
Rakesh K. Jain Harvard University
Dan G. Duda
Dan G. Duda Harvard University
Jeffrey W. Clark
Jeffrey W. Clark Harvard University
Dai Fukumura
Dai Fukumura Harvard University
Lance L. Munn
Lance L. Munn Harvard University
Earl Carstens
Earl Carstens University of California, Davis
David P. Ryan
David P. Ryan Harvard University
Andrew X. Zhu
Andrew X. Zhu Harvard University
Cristina R. Ferrone
Cristina R. Ferrone Harvard University
Christopher G. Willett
Christopher G. Willett Duke University

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