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Molecular Biology

D-Index
54
Citations
28074
World Ranking
2293
National Ranking
1130

Overview

Sandra Orsulic is affiliated with the University of California, Los Angeles in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific focus on Molecular Biology, Oncology, Reproductive Medicine, Immunology, and Cancer Research.

Their work covers multiple key topics in cancer research, including:

  • Ovarian cancer diagnosis and treatment
  • Cancer Immunotherapy and Biomarkers
  • PARP inhibition in cancer therapy
  • Cancer Cells and Metastasis
  • Immune cells in cancer
  • Cancer, Lipids, and Metabolism
  • DNA Repair Mechanisms

Recent publications by Sandra Orsulic include:

  • "Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment," 2021, Nature Communications
  • "Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer," 2020, Cell Death and Disease
  • "Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids," 2022, Proceedings of the National Academy of Sciences
  • "Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors," 2020, EMBO Molecular Medicine
  • "Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas," 2024, Nature Communications

The venues where Sandra Orsulic most frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gynecologic Oncology
  • Cancer Research
  • Nature Communications
  • Frontiers in Oncology

Sandra Orsulic frequently collaborates with the following researchers:

  • Beth Y. Karlan
  • Ann E. Walts
  • María Sol Recouvreux
  • Jenny Lester
  • David G. Huntsman

Best Publications

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

  • Integrated genomic characterization of endometrial carcinoma

    Gad Getz;Stacey B. Gabriel;Kristian Cibulskis;Eric Lander

  • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

    Stephan Gasser;Sandra Orsulic;Eric J. Brown;David H. Raulet

  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Ganna Chornokur;Hui-Yi Lin;Jonathan P. Tyrer;Kate Lawrenson

  • E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation

    Sandra Orsulic;Otmar Huber;Hermann Aberle;Sebastian Arnold

  • A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

    Ashton C Berger;Anil Korkut;Rupa S Kanchi;Apurva M Hegde

  • Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers

    Shan Deng;Shan Deng;Xiaojun Yang;Xiaojun Yang;Heini Lassus;Shun-Zhi Liang

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Mouse Models of Cancer

    Dong-Joo Cheon;Sandra Orsulic

  • Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

    Sandra Orsulic;Yi Li;Robert A. Soslow;Lynn A. Vitale-Cross

  • An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.

    Sandra Orsulic;Mark Peifer

  • A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

    Dong-Joo Cheon;Yunguang Tong;Myung-Shin Sim;Judy Dering

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • Negative regulation of Armadillo, a Wingless effector in Drosophila

    Li Mei Pai;Sandra Orsulic;Amy Bejsovec;Mark Peifer

  • Dose-Response Association of CD8(+) Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

    Ellen L. Goode;Matthew S. Block;Kimberly R. Kalli;Robert A. Vierkant

  • Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene

    Chad A Hall;Runsheng Wang;Jiangyong Miao;Esther Oliva

  • CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

    Elda Righi;Satoshi Kashiwagi;Jianping Yuan;Michael Santosuosso

  • A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis

    Mark Peifer;Sandra Orsulic;Dari Sweeton;Eric Wieschaus

  • Development of a flexible and specific gene delivery system for production of murine tumor models.

    Galen H Fisher;Sandra Orsulic;Eric Holland;Wendy P Hively

  • ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

    Ellen L. Hedditch;Bo Gao;Amanda J. Russell;Yi Lu

Frequent Co-Authors

Beth Y. Karlan
Beth Y. Karlan University of California, Los Angeles
Peter A. Fasching
Peter A. Fasching University of Erlangen-Nuremberg
Susan J. Ramus
Susan J. Ramus University of New South Wales
Graham G. Giles
Graham G. Giles University of Melbourne
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Ian G. Campbell
Ian G. Campbell Peter MacCallum Cancer Centre
Andrew Berchuck
Andrew Berchuck Duke University
Marc T. Goodman
Marc T. Goodman Cedars-Sinai Medical Center
Douglas A. Levine
Douglas A. Levine New York University
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute

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