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Biology and Biochemistry

D-Index
55
Citations
10136
World Ranking
15129
National Ranking
440

Overview

Randy Yat Choi Poon is affiliated with the Hong Kong University of Science and Technology in China. Their research predominantly centers on biochemistry, genetics, and molecular biology, with a focus on molecular biology, cell biology, oncology, genetics, and plant science as key subfields of study.

Their work addresses several main topics including:

  • Microtubule and mitosis dynamics
  • Ubiquitin and proteasome pathways
  • Cancer-related molecular pathways
  • DNA repair mechanisms
  • Genomic variations and chromosomal abnormalities
  • Mitochondrial function and pathology
  • 14-3-3 protein interactions

They have contributed to notable publication venues such as:

  • Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
  • Oncogene
  • Cell Reports
  • International Journal of Molecular Sciences
  • Methods in Molecular Biology

Selected recent publications authored or co-authored by Randy Yat Choi Poon include:

  • "Aurora kinases and DNA damage response," 2020, Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
  • "Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint," 2020, Oncogene
  • "Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells," 2021, Cell Reports
  • "Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble," 2023, International Journal of Molecular Sciences
  • "Cell Cycle Control: A System of Interlinking Oscillators," 2021, Methods in Molecular Biology

Frequent collaborators in their research include:

  • Hoi Tang
  • Tsz Kwan Yeung
  • Ho Wai Lau
  • Thomas T.Y. Lau
  • Lau Yan Ng

Best Publications

  • Cyclin A in cell cycle control and cancer.

    C H Yam;Tsz Kan Fung;R Y C Poon

  • The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

    R. Y. C. Poon;K. Yamashita;J. P. Adamczewski;T. Hunt

  • Cyclin-dependent kinases and S phase control in mammalian cells.

    Richard A. Woo;Randy Yat Choi Poon

  • On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.

    H Kobayashi;J Minshull;C Ford;R Golsteyn

  • Redistribution of the CDK Inhibitor p27 between Different Cyclin CDK Complexes in the Mouse Fibroblast Cell Cycle and in Cells Arrested with Lovastatin or Ultraviolet Irradiation.

    R. Y. C. Poon;H. Toyoshima;T. Hunter

  • Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

    H Kobayashi;E Stewart;R Poon;J P Adamczewski

  • A roller coaster ride with the mitotic cyclins.

    Tsz Kan Fung;Randy Yat Choi Poon

  • Dephosphorylation of Cdk2 Thr160 by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

    Randy Y. C. Poon;Tony Hunter

  • Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

    Jeffrey H. Albrecht;Randy Yat Choi Poon;Randy Yat Choi Poon;Cory L. Ahonen;Brenda M. Rieland

  • Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage

    Randy Y.C. Poon;Wei Jiang;Hideo Toyoshima;Tony Hunter

  • How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer

    Wan Mui Chan;Wai Yi Siu;Anita Wan Sze Lau;Randy Yat Choi Poon

  • Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells.

    Asoke Mal;Randy Y. C. Poon;Philip H. Howe;Hideo Toyoshima

  • The Role of Cdc2 Feedback Loop Control in the DNA Damage Checkpoint in Mammalian Cells

    Randy Yat Choi Poon;Man Sang Chau;Katsumi Yamashita;Tony R. Hunter

  • MDM2 and MDMX bind and stabilize the p53-related protein p73

    Weg M. Ongkeko;Xiaoqian Wang;Wai Yi Siu;Anita Wan Sze Lau

  • Synchronization of HeLa Cells

    Hoi Tang Ma;Randy Y.C. Poon

  • Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation.

    Richard A. Woo;Randy Yat Choi Poon

  • Identification of Functional Domains in the Neuronal Cdk5 Activator Protein

    Randy Yat Choi Poon;John Lew;Tony R. Hunter

  • DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

    Fei Ye;Eunchai Kang;Eunchai Kang;Chuan Yu;Xuyu Qian;Xuyu Qian

  • The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.

    Yue Chen;Randy Yat Choi Poon

  • On the Concentrations of Cyclins and Cyclin-Dependent Kinases in Extracts of Cultured Human Cells†

    Talha Arooz;Cain H. Yam;Wai Yi Siu;Anita Wan Sze Lau

Frequent Co-Authors

Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Tim Hunt
Tim Hunt University of Cambridge
Chung Mau Lo
Chung Mau Lo University of Hong Kong
Mingjie Zhang
Mingjie Zhang Hong Kong University of Science and Technology
Hitoshi Nakagama
Hitoshi Nakagama National Cancer Research Institute, UK
Michael Howell
Michael Howell The Francis Crick Institute
Chu-Xia Deng
Chu-Xia Deng University of Macau
Hongjun Song
Hongjun Song University of Pennsylvania
Guo Li Ming
Guo Li Ming University of Pennsylvania
Irene Oi-Lin Ng
Irene Oi-Lin Ng University of Hong Kong

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