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Hiroshi Ohta

Hiroshi Ohta

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
12457
World Ranking
17477
National Ranking
1264

Overview

Hiroshi Ohta is affiliated with Kyoto University in Japan and specializes in research at the intersection of biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields including molecular biology, pulmonary and respiratory medicine, oncology, public health, environmental and occupational health, and immunology.

The primary topics addressed in Ohta's research include:

  • Pluripotent Stem Cells Research
  • Veterinary Oncology Research
  • Reproductive Biology and Fertility
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Renal and related cancers
  • CRISPR and Genetic Engineering

Ohta has contributed to several peer-reviewed papers in well-regarded journals. Notable recent publications are:

  • "In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells," 2021, Cell Stem Cell
  • "ZGLP1 is a determinant for the oogenic fate in mice," 2020, Science
  • "PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma," 2021, npj Precision Oncology
  • "Long-term expansion with germline potential of human primordial germ cell-like cells in vitro," 2020, The EMBO Journal
  • "Generation of functional oocytes from male mice in vitro," 2023, Nature

Ohta frequently publishes in journals such as The EMBO Journal, PLoS ONE, Cell Stem Cell, Science, and npj Precision Oncology.

Numerous collaborations have been a feature of Ohta's research career. Frequent co-authors include:

  • Mitinori Saitou
  • Yukihiro Yabuta
  • Takuya Yamamoto
  • Yoshiaki Nosaka
  • Tatsuya Deguchi

Best Publications

  • Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

    Katsuhiko Hayashi;Hiroshi Ohta;Kazuki Kurimoto;Shinya Aramaki

  • Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

    Katsuhiko Hayashi;Katsuhiko Hayashi;Sugako Ogushi;Kazuki Kurimoto;So Shimamoto

  • Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer

    Satoshi Kishigami;Eiji Mizutani;Hiroshi Ohta;Takafusa Hikichi

  • A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

    Yasuhide Ohinata;Hiroshi Ohta;Mayo Shigeta;Kaori Yamanaka

  • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.

    Kotaro Sasaki;Shihori Yokobayashi;Tomonori Nakamura;Ikuhiro Okamoto

  • Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway

    Yuko Tadokoro;Kentaro Yomogida;Hiroshi Ohta;Akira Tohda

  • Induction of mouse germ-cell fate by transcription factors in vitro

    Fumio Nakaki;Katsuhiko Hayashi;Katsuhiko Hayashi;Hiroshi Ohta;Kazuki Kurimoto

  • Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF.

    Hiroshi Ohta;Kentaro Yomogida;Kayoko Dohmae;Yoshitake Nishimune

  • PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells

    Masashi Yamaji;Jun Ueda;Katsuhiko Hayashi;Katsuhiko Hayashi;Hiroshi Ohta

  • A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants

    Shinya Aramaki;Katsuhiko Hayashi;Kazuki Kurimoto;Hiroshi Ohta

  • Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions.

    Kumi Ozaki-Kuroda;Hiroyuki Nakanishi;Hiroshi Ohta;Hiromitsu Tanaka

  • Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

    Kazuki Kurimoto;Yukihiro Yabuta;Katsuhiko Hayashi;Katsuhiko Hayashi;Katsuhiko Hayashi;Hiroshi Ohta

  • TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.

    Yukihiro Yabuta;Hiroshi Ohta;Takaya Abe;Kazuki Kurimoto

  • Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia

    Kazutoshi Fujita;Hiroshi Ohta;Akira Tsujimura;Tetsuya Takao

  • Equivalency of Nuclear Transfer‐Derived Embryonic Stem Cells to Those Derived from Fertilized Mouse Blastocysts

    Sayaka Wakayama;Martin L. Jakt;Masako Suzuki;Ryoko Araki

  • Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer.

    Satoshi Kishigami;Hong-Thuy Bui;Sayaka Wakayama;Kenzo Tokunaga

  • In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.

    Yukiko Ishikura;Yukihiro Yabuta;Hiroshi Ohta;Katsuhiko Hayashi

  • Production of healthy cloned mice from bodies frozen at −20°C for 16 years

    Sayaka Wakayama;Hiroshi Ohta;Takafusa Hikichi;Eiji Mizutani

  • Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells.

    Kenjiro Adachi;Itoshi Nikaido;Hiroshi Ohta;Satoshi Ohtsuka

  • DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

    Morito Sakaue;Hiroshi Ohta;Yuichi Kumaki;Masaaki Oda

Frequent Co-Authors

Teruhiko Wakayama
Teruhiko Wakayama University of Yamanashi
Mitinori Saitou
Mitinori Saitou Kyoto University
Katsuhiko Hayashi
Katsuhiko Hayashi Osaka University
Yoshitake Nishimune
Yoshitake Nishimune Osaka University
Takuya Yamamoto
Takuya Yamamoto Kyoto University
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Hitoshi Niwa
Hitoshi Niwa Kumamoto University
Masaru Okabe
Masaru Okabe Osaka University
Shinichi Aizawa
Shinichi Aizawa Kumamoto University
Hiroyuki Sasaki
Hiroyuki Sasaki Kyushu University

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