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Overview

Rajyalakshmi Luthra is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on cancer-related studies.

The main subfields of study for their work include Cancer Research, Hematology, Oncology, Molecular Biology, and Pathology and Forensic Medicine. Their research topics cover a diverse range of cancer-specific areas such as Cancer Genomics and Diagnostics, Acute Myeloid Leukemia Research, Lung Cancer Treatments and Mutations, Genetic Factors in Colorectal Cancer, RNA Modifications and Cancer, and Lymphoma Diagnosis and Treatment, as well as Cancer Immunotherapy and Biomarkers.

They have published extensively, with frequent articles appearing in several key academic journals. The most common venues for their publications are:

  • Cancer Genetics
  • Journal of Clinical Oncology
  • Blood
  • Cancer Cytopathology
  • Cancers

Rajyalakshmi Luthra frequently collaborates with a number of coauthors, including:

  • Keyur P. Patel
  • L. Jeffrey Medeiros
  • Rashmi Kanagal-Shamanna
  • Dzifa Y. Duose
  • Mark J. Routbort

Recent publications by Rajyalakshmi Luthra include the following:

  • Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity (2022, Cancer Cell)
  • High-resolution structural variant profiling of myelodysplastic syndromes by optical genome mapping uncovers cryptic aberrations of prognostic and therapeutic significance (2022, Leukemia)
  • Targeted next-generation sequencing of circulating cell-free DNA vs bone marrow in patients with acute myeloid leukemia (2020, Blood Advances)
  • Utilization of cytology smears improves success rates of RNA-based next-generation sequencing gene fusion assays for clinically relevant predictive biomarkers (2020, Cancer Cytopathology)
  • Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial (2024, Clinical Cancer Research)

Best Publications

  • Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative

    Apostolia M. Tsimberidou;Nancy G. Iskander;David S. Hong;Jennifer J. Wheler

  • PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations

    Filip Janku;Jennifer J. Wheler;Shannon N. Westin;Stacy L. Moulder

  • Pegylated Interferon Alfa-2a Yields High Rates of Hematologic and Molecular Response in Patients With Advanced Essential Thrombocythemia and Polycythemia Vera

    Alfonso Quintás-Cardama;Hagop Kantarjian;Taghi Manshouri;Rajyalakshmi Luthra

  • Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia

    Farhad Ravandi;Jorge E Cortes;Daniel Jones;Stefan H Faderl

  • Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

    Z. Chen;Yu-Hong Li;H. Zhang;Peng Huang

  • PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors

    Filip Janku;Apostolia Maria Tsimberidou;Ignacio Garrido-Laguna;Xuemei Wang

  • Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.

    Karen H. Lu;John O. Schorge;Kerry J. Rodabaugh;Molly S. Daniels

  • Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes

    Rajesh R. Singh;Keyur P. Patel;Mark J. Routbort;Neelima G. Reddy

  • Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate

    Jorge Cortes;Moshe Talpaz;Susan O'Brien;Dan Jones

  • Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma.

    Russell R. Broaddus M.D.;Henry T. Lynch;Lee-may Chen;Molly S. Daniels

  • Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: An uncontrolled trial

    Gideon Steinbach;Richard Ford;Gary Glober;Dory Sample

  • MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers

    Rajyalakshmi Luthra;Rajesh R Singh;M. G. Luthra;Y. X. Li

  • PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials

    Filip Janku;Jennifer J. Wheler;Aung Naing;Gerald S. Falchook

  • Classifying colorectal cancer by tumor location rather than sidedness highlights a continuum in mutation profiles and consensus molecular subtypes

    Jonathan M Loree;Allan Al Pereira;Michael Lam;Alexandra N Willauer

  • Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors.

    Filip Janku;David S. Hong;Siqing Fu;Sarina A. Piha-Paul

  • Long-term outcome of acute promyelocytic leukemia treated with all- trans-retinoic acid, arsenic trioxide, and gemtuzumab

    Yasmin Abaza;Hagop M. Kantarjian;Guillermo Garcia-Manero;Elihu Estey

  • Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-α

    Hagop M. Kantarjian;Jorge E. Cortes;Susan O'Brien;Rajyalakshmi Luthra

  • Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy.

    Farhad Ravandi;Jeffrey L. Jorgensen;Deborah A. Thomas;Susan O'Brien

  • PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

    Filip Janku;J. Jack Lee;Apostolia M. Tsimberidou;David S. Hong

  • Effects of Cyclin D1 Polymorphism on Age of Onset of Hereditary Nonpolyposis Colorectal Cancer

    Shouming Kong;Christopher I. Amos;Rajyalakshmi Luthra;Patrick M. Lynch

Frequent Co-Authors

L. Jeffrey Medeiros
L. Jeffrey Medeiros The University of Texas MD Anderson Cancer Center
Hagop M. Kantarjian
Hagop M. Kantarjian The University of Texas MD Anderson Cancer Center
Jorge E. Cortes
Jorge E. Cortes Augusta University
Farhad Ravandi
Farhad Ravandi The University of Texas MD Anderson Cancer Center
Guillermo Garcia-Manero
Guillermo Garcia-Manero The University of Texas MD Anderson Cancer Center
Russell Broaddus
Russell Broaddus University of North Carolina at Chapel Hill
Susan O'Brien
Susan O'Brien University of California, Irvine
Filip Janku
Filip Janku The University of Texas MD Anderson Cancer Center
Funda Meric-Bernstam
Funda Meric-Bernstam The University of Texas MD Anderson Cancer Center
Elias Jabbour
Elias Jabbour The University of Texas MD Anderson Cancer Center

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