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Paul H. Naccache

Paul H. Naccache

D-Index & Metrics

Microbiology

D-Index
74
Citations
13896
World Ranking
1611
National Ranking
49

Overview

Paul H. Naccache is affiliated with Université Laval in Canada and has contributed to several scientific publications primarily in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Their work includes research on immunology, immunology and allergy, cell biology, nephrology, and molecular biology.

The scientist's research covers a variety of topics, including:

  • Cell Adhesion Molecules Research
  • Caveolin-1 and cellular processes
  • Immune Response and Inflammation
  • Gout, Hyperuricemia, Uric Acid
  • Inflammasome and immune disorders
  • Curcumin's Biomedical Applications
  • Galectins and Cancer Biology

Recent publications authored or coauthored by Paul H. Naccache include the following papers:

  • The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release, 2021, published in Frontiers in Immunology
  • The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout, 2020, published in Biochemical Pharmacology
  • Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region, 2021, published in International Journal of Molecular Sciences

Frequent coauthors in this research include Guillaume Paré, Julien Vitry, Maria J. Fernandes, Myriam Vaillancourt, and Andréa Murru.

Paul H. Naccache's work has appeared in multiple publication venues, among which Frontiers in Immunology, Biochemical Pharmacology, and International Journal of Molecular Sciences stand out for featuring several of their studies.

Best Publications

  • Transport of sodium, potassium, and calcium across rabbit polymorphonuclear leukocyte membranes. Effect of chemotactic factor.

    P H Naccache;H J Showell;E L Becker;R I Sha'afi

  • Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.

    P A Tessier;P H Naccache;I Clark-Lewis;R P Gladue

  • Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.

    J R White;C K Huang;J M Hill;P H Naccache

  • Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium.

    R.I. Sha'afi;J.R. White;T.F.P. Molski;J. Shefcyk

  • Direct demonstration of increased intracellular concentration of free calcium in rabbit and human neutrophils following stimulation by chemotactic factor.

    J.R. White;P.H. Naccache;T.F.P. Molski;P. Borgeat

  • Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils

    M. Volpi;R. Yassin;P.H. Naccache;R.I. Sha'afi

  • Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils SELECTIVE ACTIVATION OF Jak2, Stat3, AND Stat5B

    Amin Al-Shami;Wahib Mahanna;Paul H. Naccache

  • Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

    P H Naccache;T F Molski;P Borgeat;J R White

  • Changes in ionic movements across rabbit polymorphonuclear leukocyte membranes during lysosomal enzyme release. Possible ionic basis for lysosomal enzyme release.

    P H Naccache;H J Showell;E L Becker;R I Sha'afi

  • Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization

    T.F.P. Molski;P.H. Naccache;M.L. Marsh;J. Kermode

  • Chemotactic factor-induced release of membrane calcium in rabbit neutrophils

    PH Naccache;M Volpi;HJ Showell;EL Becker

  • Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

    Mario Volpi;Paul H. Naccache;Thaddeus F. P. Molski;Jean Shefcyk

  • Stimulation by chemotactic factor of actin association with the cytoskeleton in rabbit neutrophils. Effects of calcium and cytochalasin B.

    J R White;P H Naccache;R I Sha'afi

  • The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.

    E L Becker;J C Kermode;P H Naccache;R Yassin

  • Crystal‐induced neutrophil activation

    Unknown

  • Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis.

    Mohamed Hachicha;P. H. Naccache;S. R. Mccoll

  • Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes

    Marc Pouliot;Michael J. James;Michael J. James;Michael J. James;Shaun R. McColl;Shaun R. McColl;Shaun R. McColl;Paul H. Naccache;Paul H. Naccache;Paul H. Naccache

  • Involvement of membrane calcium in the response of rabbit neutrophils to chemotactic factors as evidenced by the fluorescence of chlorotetracycline.

    P H Naccache;H J Showell;E L Becker;R I Sha'afi

  • Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

    H J Showell;P H Naccache;P Borgeat;S Picard

  • Priming of the human neutrophil respiratory burst by granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha involves regulation at a post-cell surface receptor level. Enhancement of the effect of agents which directly activate G proteins.

    S R McColl;D Beauseigle;C Gilbert;P H Naccache

  • Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity

    Gaέtan P. L'Heureux;Sylvain Bourgoin;Nathalie Jean;Shaun R. McColl

Frequent Co-Authors

Shaun R. McColl
Shaun R. McColl University of Adelaide
Pierre Borgeat
Pierre Borgeat Université Laval
Sylvain G. Bourgoin
Sylvain G. Bourgoin Université Laval
Ramadan I. Sha'afi
Ramadan I. Sha'afi University of Connecticut Health Center
Guillaume Paré
Guillaume Paré Population Health Research Institute
Elmer L. Becker
Elmer L. Becker University of Connecticut Health Center
Stephen E. Malawista
Stephen E. Malawista Yale University
John F. DiPersio
John F. DiPersio Washington University in St. Louis
Ian Clark-Lewis
Ian Clark-Lewis University of British Columbia
François Marceau
François Marceau Université Laval

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