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Molecular Biology

D-Index
42
Citations
6283
World Ranking
3030
National Ranking
1437

Overview

Paul D. Friesen is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with particular emphasis on Molecular Biology as a subfield. The work of Friesen covers topics such as Viral Infectious Diseases and Gene Expression in Insects, CRISPR and Genetic Engineering, and Insect Resistance and Genetics.

The scientist has contributed to several peer-reviewed publications in notable venues. Among these are:

  • International Influence: The Hidden Dimension, 2021, SSRN Electronic Journal
  • Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection, 2022, Journal of Virology
  • Biographical Feature: Diane E. Griffin and Ann Palmenberg-luminaries in RNA virology, 2025, Journal of Virology

Friesen's frequent co-authors include:

  • Benjamin Denison
  • Lucía Tiscornia
  • Robert F. Kalejta
  • Michael Coppedge
  • Yang Xu

Regarding publication venues, Friesen has most often published in the Journal of Virology and SSRN Electronic Journal. These journals have hosted the majority of their scientific contributions.

The research topics regularly addressed by Friesen reflect interests in the molecular mechanisms of viral infections in insects, the application and development of CRISPR and genetic engineering techniques, as well as the genetic basis for insect resistance. This interdisciplinary focus integrates molecular biology approaches with virology and genetic engineering technologies.

Best Publications

  • The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

    David R. Beidler;Muneesh Tewari;Paul D. Friesen;Guy Poirier

  • Expression of the Baculovirus p35 Gene Inhibits Mammalian Neural Cell Death

    S. Rabizadeh;D. J. LaCount;P. D. Friesen;D. E. Bredesen

  • Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans.

    Asako Sugimoto;Paul D. Friesen;Joel H. Rothman

  • Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease.

    J Bertin;S M Mendrysa;D J LaCount;S Gaur

  • Regulation of Baculovirus Early Gene Expression

    Paul D. Friesen

  • Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa californica nuclear polyhedrosis virus: cell line-specific effects on virus replication.

    P A Hershberger;J A Dickson;P D Friesen

  • Location, transcription, and sequence of a baculovirus gene encoding a small arginine-rich polypeptide.

    M E Wilson;T H Mainprize;P D Friesen;L K Miller

  • Molecular analysis of the transcriptional regulatory region of an early baculovirus gene.

    M S Nissen;P D Friesen

  • Divergent transcription of early 35- and 94-kilodalton protein genes encoded by the HindIII K genome fragment of the baculovirus Autographa californica nuclear polyhedrosis virus.

    P D Friesen;L K Miller

  • The hr5 transcriptional enhancer stimulates early expression from the Autographa californica nuclear polyhedrosis virus genome but is not required for virus replication.

    Steven M. Rodems;Paul D. Friesen

  • Gene organization and transcription of TED, a lepidopteran retrotransposon integrated within the baculovirus genome.

    P D Friesen;M S Nissen

  • Transcriptional enhancer activity of hr5 requires dual-palindrome half sites that mediate binding of a dimeric form of the baculovirus transregulator IE1.

    S M Rodems;P D Friesen

  • Suppression of apoptosis in insect cells stably transfected with baculovirus p35: dominant interference by N-terminal sequences p35(1-76).

    J L Cartier;P A Hershberger;P D Friesen

  • The apoptotic suppressor P35 is required early during baculovirus replication and is targeted to the cytosol of infected cells.

    P A Hershberger;D J LaCount;P D Friesen

  • Synthesis of Black Beetle Virus Proteins in Cultured Drosophila Cells: Differential Expression of RNAs 1 and 2.

    Paul D. Friesen;Roland R. Rueckert

  • Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death.

    Gulam A. Manji;Rebecca R. Hozak;Douglas J. Lacount;Paul D. Friesen

  • Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.

    Andrew J. Fisher;Wilfred dela Cruz;Stephen J. Zoog;Christine L. Schneider

  • Caspase Inhibitor P35 and Inhibitor of Apoptosis Op-IAP Block in Vivo Proteolytic Activation of an Effector Caspase at Different Steps

    Douglas J. LaCount;Stephen F. Hanson;Christine L. Schneider;Paul D. Friesen

  • Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

    Stephen J. Zoog;Jennifer J. Schiller;Justin A. Wetter;Nor Chejanovsky

  • Identification of upstream promoter elements mediating early transcription from the 35,000-molecular-weight protein gene of Autographa californica nuclear polyhedrosis virus

    J A Dickson;P D Friesen

Frequent Co-Authors

Roland R. Rueckert
Roland R. Rueckert University of Wisconsin–Madison
Lois K. Miller
Lois K. Miller University of Georgia
Emad S. Alnemri
Emad S. Alnemri Thomas Jefferson University
Teresa Fernandes-Alnemri
Teresa Fernandes-Alnemri Thomas Jefferson University
Paul Ahlquist
Paul Ahlquist University of Wisconsin–Madison
Kevin J. Tomaselli
Kevin J. Tomaselli Pfizer (United States)
Renato Baserga
Renato Baserga Thomas Jefferson University
Gerald Litwack
Gerald Litwack Texas A&M Health Science Center
Muneesh Tewari
Muneesh Tewari University of Michigan–Ann Arbor
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles

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