Kevin J. Tomaselli

Overview

Best Publications

• An inhibitor of Bcl-2 family proteins induces regression of solid tumours

  Tilman Oltersdorf;Steven W. Elmore;Alexander R. Shoemaker;Robert C. Armstrong

  4097
  Citations

• Two CD95 (APO-1/Fas) signaling pathways

  Carsten Scaffidi;Simone Fulda;Anu Srinivasan;Claudia Friesen

  4059
  Citations

• Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

  Shobu Namura;Jinmin Zhu;Klaus Fink;Matthias Endres

  1166
  Citations

• Extracellular Matrix Molecules and their Receptors: Functions in Neural Development

  Louis F. Reichardt;Kevin J. Tomaselli

  1087
  Citations

• In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

  Teresa Fernandes-Alnemri;Robert C. Armstrong;Joseph Krebs;Srinivasa M. Srinivasula

  1023
  Citations

• Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

  Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  722
  Citations

• Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

  John Bertin;Robert C. Armstrong;Sabine Ottilie;David A. Martin

  594
  Citations

• Mch3, a Novel Human Apoptotic Cysteine Protease Highly Related to CPP32

  T Fernandes-Alnemri;A Takahashi;R Armstrong;J Krebs

  519
  Citations

• Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

  Thorsten K Oost;Chaohong Sun;Robert C Armstrong;Ali-Samer Al-Assaad

  493
  Citations

• FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

  Srinivasa M. Srinivasula;Manzoor Ahmad;Sabine Ottilie;Florencia Bullrich

  458
  Citations

• Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release.

  Feng Li;Anu Srinivasan;Yu Wang;Robert C. Armstrong

  457
  Citations

• In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

  Anu Srinivasan;Kevin A Roth;Robert O Sayers;Kenneth S Shindler

  434
  Citations

• Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors

  Robert C. Armstrong;Teresa Aja;Jialing Xiang;Smita Gaur

  432
  Citations

• Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

  C.E. Milligan;D. Prevette;H. Yaginuma;S. Homma

  429
  Citations

• N-Cadherin and Integrins: Two Receptor Systems That Mediate Neuronal Process Outgrowth on Astrocyte Surfaces

  Kevin J. Tomaselli;Karla M. Neugebauer;John L. Bixby;Jack Lilien

  428
  Citations

• The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

  Srinivasa M. Srinivasula;Teresa Fernandes-Alnemri;James Zangrilli;Noreen Robertson

  426
  Citations

• Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.

  Robert C. Armstrong;Teresa J. Aja;Kim D. Hoang;Smita Gaur

  417
  Citations

• N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.

  K M Neugebauer;K J Tomaselli;J Lilien;L F Reichardt

  392
  Citations

• Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.

  Peer R.E. Mittl;Stefania Di Marco;Joseph F. Krebs;Xu Bai

  365
  Citations

• Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.

  Shin-Jung Kang;Suyue Wang;Hideaki Hara;Erin P. Peterson

  363
  Citations