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Michael J. O'Connell

Michael J. O'Connell

D-Index & Metrics

Medicine

D-Index
104
Citations
45754
World Ranking
6991
National Ranking
3677

Overview

Michael J. O'Connell is affiliated with the Mayo Clinic in the United States and has contributed extensively to research in medicine, biochemistry, genetics, and molecular biology. Their work spans various subfields, prominently molecular biology and oncology, with additional focus on ecology, pathology and forensic medicine, and surgery.

Their research primarily centers on colorectal cancer, covering treatments, genetic factors, screening, detection, and surgical approaches. Other significant topics include gene expression and cancer classification, bioinformatics and genomic networks, and colorectal and anal carcinomas.

Recent published papers include the following:

  • Microsatellite Instability in Patients With Stage III Colon Cancer Receiving Fluoropyrimidine With or Without Oxaliplatin: An ACCENT Pooled Analysis of 12 Adjuvant Trials (2020, Journal of Clinical Oncology)
  • Sex and Adverse Events of Adjuvant Chemotherapy in Colon Cancer: An Analysis of 34,640 Patients in the ACCENT Database (2020, JNCI Journal of the National Cancer Institute)
  • Clinicopathological and Molecular Characteristics of Early-Onset Stage III Colon Adenocarcinoma: An Analysis of the ACCENT Database (2021, JNCI Journal of the National Cancer Institute)
  • Lens Epithelial Explants Treated with Vitreous Humor Undergo Alterations in Chromatin Landscape with Concurrent Activation of Genes Associated with Fiber Cell Differentiation and Innate Immune Response (2023, Cells)
  • Assessing the Quality of Rectal Cancer Pathology Reports in National Surgical Adjuvant Breast and Bowel Project Protocol R-04/NRG Oncology (2020, Diseases of the Colon & Rectum)

Frequent co-authors collaborating with Michael J. O'Connell include:

  • Richard M. Goldberg
  • Greg Yothers
  • Carmen J. Allegra
  • Norman Wolmark
  • Aimery de Gramont

Their work is published across various venues, with notable contributions in:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JNCI Journal of the National Cancer Institute
  • Bioinformatics Advances
  • Journal of Clinical Oncology

Michael J. O'Connell's academic production features a strong interdisciplinary approach, integrating molecular biology and oncology to investigate colorectal cancer's clinical and molecular characteristics. Their research provides data-driven analysis in chemotherapy effects, genetic instability, and cancer pathology reporting, reflecting broad expertise in medicine and genomic sciences.

Best Publications

  • Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5‐fluorouracil), and high dose radiation + 5‐fluorouracil. The gastrointestinal tumor study group

    C. G. Moertel;S. Frytak;R. G. Hahn;M. J. O'Connell

  • Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery

    Michael J. O'Connell;James A. Martenson;Harry S. Wieand;James E. Krook

  • Oxaliplatin Combined With Weekly Bolus Fluorouracil and Leucovorin As Surgical Adjuvant Chemotherapy for Stage II and III Colon Cancer: Results From NSABP C-07

    J. Philip Kuebler;H. Samuel Wieand;Michael J. O'Connell;Roy E. Smith

  • Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

    M A Poon;M J O'Connell;C G Moertel;H S Wieand

  • Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analogue.

    Larry K. Kvols;Charles G. Moertel;Michael J. O'Connell;Allan J. Schutt

  • Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms

    Charles G. Moertel;Larry K. Kvols;Michael J. O'Connell;Joseph Rubin

  • Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03

    Mark S. Roh;Linda H. Colangelo;Michael J. O'Connell;Greg Yothers

  • High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison.

    Charles G. Moertel;Thomas R. Fleming;Edward T. Creagan;Joseph Rubin

  • Disease-Free Survival Versus Overall Survival As a Primary End Point for Adjuvant Colon Cancer Studies: Individual Patient Data From 20,898 Patients on 18 Randomized Trials

    Daniel J. Sargent;Harry S. Wieand;Daniel G. Haller;Richard Gray

  • Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer.

    M J O'Connell;J A Mailliard;M J Kahn;J S Macdonald

  • Impact of Number of Nodes Retrieved on Outcome in Patients With Rectal Cancer

    Joel E. Tepper;Michael J. O’Connell;Donna Niedzwiecki;Donna Hollis

  • Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

    Stephen N. Thibodeau;Amy J. French;Julie M. Cunningham;David Tester

  • Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial.

    Edward T. Creagan;Charles G. Moertel;Judith R. O'Fallon;Allan J. Schutt

  • Oxaliplatin As Adjuvant Therapy for Colon Cancer: Updated Results of NSABP C-07 Trial, Including Survival and Subset Analyses

    Greg Yothers;Michael J. O'Connell;Carmen J. Allegra;J. Philip Kuebler

  • Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials

    Daniel Sargent;Alberto Sobrero;Axel Grothey;Michael J. O'Connell

  • Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08

    Carmen J. Allegra;Greg Yothers;Michael J. O'Connell;Saima Sharif

  • Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer.

    P Piedbois;M Buyse;N Kemeny

  • Impact of T and N Stage and Treatment on Survival and Relapse in Adjuvant Rectal Cancer A Pooled Analysis

    Leonard L. Gunderson;Daniel Jay Sargent;Joel E. Tepper;Norman Wolmark

  • Carcinoma of the anal canal, a clinical and pathologic study of 188 cases

    Bruce M. Boman;Charles G. Moertel;Michael J. O'Connell;Mark Scott

  • Intra-arterial Floxuridine vs Systemic Fluorouracil for Hepatic Metastases From Colorectal Cancer: A Randomized Trial

    J. Kirk Martin;Michael J. O'Connell;Harry S. Wieand;Robert J. Fitzgibbons

Frequent Co-Authors

Joseph Rubin
Joseph Rubin Mayo Clinic
Norman Wolmark
Norman Wolmark University of Pittsburgh
Richard M. Goldberg
Richard M. Goldberg West Virginia University
Larry K. Kvols
Larry K. Kvols University of South Florida
Carmen J. Allegra
Carmen J. Allegra University of Florida
Martin M. Oken
Martin M. Oken University of Minnesota
Daniel G. Haller
Daniel G. Haller University of Pennsylvania

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