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Neuroscience

D-Index
64
Citations
17333
World Ranking
3228
National Ranking
1495

Overview

Mark Bothwell is affiliated with the University of Washington in the United States. Their research predominantly spans the fields of biochemistry, genetics, molecular biology, neuroscience, and medicine, with a particular focus on molecular biology, cellular and molecular neuroscience, neurology, genetics, and biochemistry.

Bothwell's work covers a range of topics that include neuroscience and neural engineering, amyotrophic lateral sclerosis (ALS) research, extracellular vesicles in disease, hereditary neurological disorders, neurogenetic and muscular disorders research, 3D printing in biomedical research, and mechanisms of neuroinflammation and neurodegeneration.

Frequent publication venues for Bothwell include Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Frontiers in Cell and Developmental Biology, Advanced Biology, Biomaterials, and the Journal of Neuroscience.

Several recent papers illustrate the scope of Bothwell's research:

  • Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro (2021, Biomaterials)
  • Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies (2021, Frontiers in Cell and Developmental Biology)
  • HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D) (2021, Advanced Biology)
  • Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFNγ Exposure (2024, Journal of Neuroscience)
  • Editorial: Modeling neuromuscular diseases to determine molecular drivers of pathology and for drug discovery (2022, Frontiers in Cell and Developmental Biology)

Bothwell collaborates frequently with several researchers, including:

  • Alec S.T. Smith
  • David L. Mack
  • Changho Chun
  • Deok-Ho Kim
  • Julie Mathieu

Best Publications

  • Expression and structure of the human NGF receptor

    Dan Johnson;Anthony Lanahan;C.Randy Buck;Amita Sehgal

  • Functional Interactions of Neurotrophins and Neurotrophin Receptors

    Mark Bothwell

  • Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs.

    Susan L. Patterson;Larry M. Grover;Philip A. Schwartzkroin;Philip A. Schwartzkroin;Mark Bothwell

  • Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

    Leslayann C. Schecterson;Mark Bothwell

  • A p75 NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

    Scott T. Wong;John R. Henley;Kevin C. Kanning;Kuo hua Huang

  • Gene transfer and molecular cloning of the human NGF receptor

    MV Chao;MA Bothwell;AH Ross;H Koprowski

  • Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene

    B.R. Seizinger;G.A. Rouleau;L.J. Ozelius;A.H. Lane

  • Keeping track of neurotrophin receptors.

    Mark Bothwell

  • Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies

    A H Ross;P Grob;M Bothwell;D E Elder

  • Neurotrophins: To Cleave or Not to Cleave

    Moses V. Chao;Mark Bothwell

  • Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system.

    Christopher S. von Bartheld;Margaret R. Byers;Reg Williams;Mark Bothwell

  • Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

    Alan L. Schechter;Mark A. Bothwell

  • Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons

    M. Marsel Mesulam;Changiz Geula;Mark A. Bothwell;Louis B. Hersh

  • Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

    Kevin C. Kanning;Mark Hudson;Paul S. Amieux;Jesse C. Wiley

  • Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain.

    Elliott J. Mufson;Mark Bothwell;Jeffrey H. Kordower

  • Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells.

    P W Gunning;G E Landreth;M A Bothwell;E M Shooter

  • Expression of NGF receptor in the developing and adult primate central nervous system

    Gina C. Schatteman;Lorraine Gibbs;Anthony A. Lanahan;Philippa Claude

  • Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons

    Elliott J. Mufson;Mark Bothwell;Louis B. Hersh;Jeffrey H. Kordower

  • NGF, BDNF, NT3, and NT4.

    M. Bothwell

  • Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear.

    Leslayann C. Schecterson;Mark Bothwell

Frequent Co-Authors

Edwin W. Rubel
Edwin W. Rubel University of Washington
Moses V. Chao
Moses V. Chao New York University
Christopher S. von Bartheld
Christopher S. von Bartheld University of Nevada Reno
Elliott J. Mufson
Elliott J. Mufson Barrow Neurological Institute
Gwenn A. Garden
Gwenn A. Garden University of North Carolina at Chapel Hill
Amita Sehgal
Amita Sehgal University of Pennsylvania
Philip A. Schwartzkroin
Philip A. Schwartzkroin University of California, Davis
M.-Marsel Mesulam
M.-Marsel Mesulam Northwestern University
Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Laurie J. Ozelius
Laurie J. Ozelius Harvard University

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