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Kensaku Mizuno

Kensaku Mizuno

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
23382
World Ranking
3902
National Ranking
252

Overview

Kensaku Mizuno is affiliated with Tohoku University in Japan and conducts research primarily within the broad field of Biochemistry, Genetics and Molecular Biology. Their work focuses particularly on subfields such as Cell Biology, Molecular Biology, Immunology and Allergy, Physiology, and Plant Science.

The scientist has contributed to understanding cellular mechanics and molecular signaling pathways. Main topics of their research include:

  • Cellular Mechanics and Interactions
  • Protein Kinase Regulation and GTPase Signaling
  • Cell Adhesion Molecules Research
  • Erythrocyte Function and Pathophysiology
  • Hippo pathway signaling and YAP/TAZ
  • Plant Surface Properties and Treatments
  • S100 Proteins and Annexins

Recent publications reflect their focus on cell signaling and cytoskeletal dynamics. Notable works include:

  • "Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP," 2020, Journal of Biological Chemistry
  • "PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation," 2020, Journal of Cell Science
  • "The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks," 2020, Molecular Biology of the Cell
  • "Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling," 2020, Journal of Biological Chemistry
  • "Solo regulates the localization and activity of PDZ-RhoGEF for actin cytoskeletal remodeling in response to substrate stiffness," 2024, Molecular Biology of the Cell

Mizuno frequently publishes in venues such as Molecular Biology of the Cell, bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Journal of Cell Science, and Frontiers in Cell and Developmental Biology.

Collaborations have involved several recurring co-authors, including Kazumasa Ohashi, Shuhei Chiba, Aoi Kunitomi, Nahoko Higashitani, and Atsushi Higashitani.

Best Publications

  • Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

    Midori Maekawa;Toshimasa Ishizaki;Shuken Boku;Naoki Watanabe

  • Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

    Neng Yang;Osamu Higuchi;Kazumasa Ohashi;Kyoko Nagata

  • Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

    Yugo Fukazawa;Yoshito Saitoh;Fumiko Ozawa;Yasuhiko Ohta

  • Control of Actin Reorganization by Slingshot, a Family of Phosphatases that Dephosphorylate ADF/Cofilin

    Ryusuke Niwa;Kyoko Nagata-Ohashi;Masatoshi Takeichi;Kensaku Mizuno

  • Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

    Kazumasa Ohashi;Kyoko Nagata;Midori Maekawa;Toshimasa Ishizaki

  • Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases

    Kyoko Nagata;Kazumasa Ohashi;Toru Nakano;Hitoshi Arita

  • Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

    Hiroyuki Aizawa;Hiroyuki Aizawa;Shuji Wakatsuki;Ai Ishii;Kenji Moriyama

  • Interaction of hepatocyte growth factor with heparan sulfate : elucidation of the major heparan sulfate structural determinants

    Malcolm Lyon;Jon A Deakin;K Mizuno;T Nakamura

  • Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation.

    Kensaku Mizuno

  • A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons

    Haruhiko Bito;Tomoyuki Furuyashiki;Hisamitsu Ishihara;Yoshikazu Shibasaki

  • Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

    Sing Rong;M. Bodescot;D. Blair;J. Dunn

  • Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.

    Jiro Toshima;Junko Y. Toshima;Toru Amano;Neng Yang

  • Protein-Protein Interaction of Zinc Finger LIM Domains with Protein Kinase C

    Shun'ichi Kuroda;Chiharu Tokunaga;Yoshimoto Kiyohara;Osamu Higuchi

  • Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.

    Yan Wang;Futoshi Shibasaki;Kensaku Mizuno

  • Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6.

    Toru Nakano;Yoshikazu Ishimoto;Junji Kishino;Masato Umeda

  • Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

    Tim Eiseler;Heike Döppler;Irene K. Yan;Kanae Kitatani

  • Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases

    Kensaku Mizuno;Tomoko Nakamura;Takehiro Ohshima;Shoji Tanaka

  • Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.

    Mitsuharu Endo;Kazumasa Ohashi;Yukio Sasaki;Yoshio Goshima

  • Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.

    Michiru Nishita;Chinatsu Tomizawa;Masahiro Yamamoto;Yuji Horita

  • Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.

    Kensaku Mizuno;Ichiro Okano;Kazumasa Ohashi;Koh Nunoue

Frequent Co-Authors

Kazumasa Ohashi
Kazumasa Ohashi Tohoku University
Hisayuki Matsuo
Hisayuki Matsuo Osaka University
Toshikazu Nakamura
Toshikazu Nakamura Osaka University
Kenji Kangawa
Kenji Kangawa National Cerebral and Cardiovascular Center
Toru Nakano
Toru Nakano Osaka University
Ryusuke Niwa
Ryusuke Niwa University of Tsukuba
Tadashi Uemura
Tadashi Uemura Kyoto University
Masayasu Kojima
Masayasu Kojima Kurume University
Shuh Narumiya
Shuh Narumiya Kyoto University
Naoto Minamino
Naoto Minamino Osaka University

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