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Biology and Biochemistry
Singapore
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
131
Citations
59977
World Ranking
391
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Singapore Leader Award
  • 2025 - Research.com Biology and Biochemistry in Singapore Leader Award

Overview

Karl Tryggvason is affiliated with Duke NUS Graduate Medical School in Singapore and has contributed extensively to the fields of Medicine, Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields, including Molecular Biology, Nephrology, Surgery, Hematology, and Genetics.

Their scholarly work covers several main topics such as:

  • Renal Diseases and Glomerulopathies
  • Chronic Kidney Disease and Diabetes
  • Congenital Heart Defects Research
  • Tissue Engineering and Regenerative Medicine
  • Cell Adhesion Molecules Research
  • Acute Myeloid Leukemia Research
  • Genetic and Kidney Cyst Diseases

Recent publications by Karl Tryggvason include:

  • "A high-resolution map of human RNA translation," 2022, Molecular Cell
  • "Periportal macrophages protect against commensal-driven liver inflammation," 2024, Nature
  • "Viral proteases activate the CARD8 inflammasome in the human cardiovascular system," 2022, The Journal of Experimental Medicine
  • "Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression," 2021, Blood
  • "Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis," 2021, Scientific Reports

Frequent collaborators include:

  • Lynn Yap (7 co-publications)
  • Enrico Petretto (7 co-publications)
  • Li Yen Chong (6 co-publications)
  • Swarnaseetha Adusumalli (5 co-publications)
  • Clarissa Tan (4 co-publications)

Their publications are frequently found in the following venues:

  • The Journal of Experimental Medicine (2 publications)
  • Molecular Cell (1 publication)
  • Nature (1 publication)
  • Blood (1 publication)
  • Scientific Reports (1 publication)

Karl Tryggvason's work integrates molecular and clinical perspectives, with a strong focus on mechanisms underlying kidney function and disease, as well as hematologic and cardiovascular research that intersects with inflammation and genetic factors. Their multidisciplinary approach reflects involvement in both fundamental molecular biology and applied clinical research.

Best Publications

  • Metastatic potential correlates with enzymatic degradation of basement membrane collagen.

    L. A. Liotta;K. Tryggvason;S. Garbisa;Ian Hart

  • Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome

    Marjo Kestilä;Ulla Lenkkeri;Minna Männikkö;Jane Lamerdin

  • Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.

    Hynda K. Kleinman;Mary L. McGarvey;Lance A. Liotta;Pamela Gehron Robey

  • Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen

    Billy G. Hudson;Karl Tryggvason;Munirathinam Sundaramoorthy;Eric G. Neilson;Eric G. Neilson

  • A simplified laminin nomenclature

    Monique Aumailley;Leena Bruckner-Tuderman;William G. Carter;Rainer Deutzmann

  • Identification of mutations in the COL4A5 collagen gene in Alport syndrome.

    David F. Barker;Sirkka Liisa Hostikka;Jing Zhou;Louise T. Chow

  • Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

    Zhongjun Zhou;Suneel S. Apte;Raija Soininen;Renhai Cao

  • A new nomenclature for the laminins.

    Robert E. Burgeson;Matthias Chiquet;Rainer Deutzmann;Peter Ekblom

  • Genomic instability in laminopathy-based premature aging

    Baohua Liu;Jianming Wang;Kui Ming Chan;Wai Mui Tjia

  • Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.

    A Helbling-Leclerc;X Zhang;H Topaloglu;C Cruaud

  • Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.

    B G Hudson;S T Reeders;K Tryggvason

  • Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria

    Karl Tryggvason;Jaakko Patrakka;Jorma Wartiovaara

  • Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.

    Ekaterina Morgunova;Ari Tuuttila;Ulrich Bergmann;Mikhail Isupov

  • X-linked Alport Syndrome Natural History in 195 Families and Genotype- Phenotype Correlations in Males

    Jean Philippe Jais;Bertrand Knebelmann;Iannis Giatras;Mario De Marchi

  • Proteolytic degradation of extracellular matrix in tumor invasion.

    K. Tryggvason;M. Höyhtyä;T. Salo

  • The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

    Ganka Nikolova;Normund Jabs;Irena Konstantinova;Anna Domogatskaya

  • Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

    Sergey Rodin;Anna Domogatskaya;Susanne Ström;Emil M Hansson

  • Defective Prelamin A Processing and Muscular and Adipocyte Alterations in Zmpste24 Metalloproteinase-Deficient Mice

    Alberto M. Pendás;Zhongjun Zhou;Juan Cadiñanos;José M.P. Freije

  • The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death

    Heli Putaala;Raija Soininen;Pekka Kilpeläinen;Jorma Wartiovaara

  • Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.

    Outi Elomaa;Maarit Kangas;Carin Sahlberg;Juha Tuukkanen

Frequent Co-Authors

Lance A. Liotta
Lance A. Liotta George Mason University
Outi Hovatta
Outi Hovatta Karolinska Institute
Christer Betsholtz
Christer Betsholtz Uppsala University
Jing Zhou
Jing Zhou Harvard University
Enrico Petretto
Enrico Petretto Duke NUS Graduate Medical School
Kari I. Kivirikko
Kari I. Kivirikko University of Oulu
Louise T. Chow
Louise T. Chow University of Alabama at Birmingham
Kjell Hultenby
Kjell Hultenby Karolinska Institute
Jean-Michel Foidart
Jean-Michel Foidart University of Liège
Thomas B. Shows
Thomas B. Shows Roswell Park Cancer Institute

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