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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
16868
World Ranking
11195
National Ranking
4844

Overview

Kaikobad Irani is affiliated with the University of Iowa in the United States. Their research primarily engages the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Epidemiology, Physiology, and Surgery.

The scientist's main research topics include:

  • Cardiac electrophysiology and arrhythmias
  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Autophagy in Disease and Therapy
  • Ion channel regulation and function
  • Adipose Tissue and Metabolism
  • Apelin-related biomedical research

Kaikobad Irani has contributed to multiple recent publications, including:

  • "Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome," 2022, Clinical and Translational Medicine
  • "Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD+ precursors," 2020, Journal of Molecular and Cellular Cardiology
  • "Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice," 2020, Scientific Reports
  • "The microRNA-204-5p inhibits APJ signalling and confers resistance to cardiac hypertrophy and dysfunction," 2022, Clinical and Translational Medicine
  • "Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome," 2023, Nature Communications

Their work has been published in various venues with multiple contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical and Translational Medicine
  • Biochemical and Biophysical Research Communications
  • Journal of Molecular and Cellular Cardiology
  • Scientific Reports

Frequent collaborators in their research include:

  • Ajit Vikram
  • Young-Rae Kim
  • Barry London
  • Ravinder Reddy Gaddam
  • Julia S. Jacobs

Best Publications

  • Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction

    Maitrayee Sundaresan;Zu Xi Yu;Victor J. Ferrans;Kaikobad Irani

  • Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

    Kaikobad Irani;Yong Xia;Jay L. Zweier;Steven J. Sollott

  • Oxidant Signaling in Vascular Cell Growth, Death, and Survival A Review of the Roles of Reactive Oxygen Species in Smooth Muscle and Endothelial Cell Mitogenic and Apoptotic Signaling

    Kaikobad Irani

  • Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

    M Sundaresan;Z X Yu;V J Ferrans;D J Sulciner

  • rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation.

    David J. Sulciner;Kaikobad Irani;Z. X. Yu;Victor J. Ferrans

  • Rac1 inhibits TNF-α-induced endothelial cell apoptosis: dual regulation by reactive oxygen species

    Shailesh S. Deshpande;Piamsook Angkeow;Jianping Huang;Michitaka Ozaki

  • Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.

    Sanae Haga;Keita Terui;Hui Qi Zhang;Shin Enosawa

  • Ras, superoxide and signal transduction.

    Irani K;Goldschmidt-Clermont Pj

  • Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism.

    Md. Ruhul Abid;Jo C. Tsai;Katherine C. Spokes;Shailesh S. Deshpande

  • SIRT1 deacetylates APE1 and regulates cellular base excision repair

    Tohru Yamamori;Jeremy DeRicco;Asma Naqvi;Timothy A. Hoffman

  • Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS

    Li Hong Yeh;Young J. Park;Riple J. Hansalia;Imraan S. Ahmed

  • Alterations in the Expression of the Apurinic/Apyrimidinic Endonuclease-1/redox Factor-1 (APE/Ref-1) in Human Melanoma and Identification of the Therapeutic Potential of Resveratrol as an APE/Ref-1 Inhibitor

    Sun Yang;Kaikobad Irani;Susan E. Heffron;Frances Jurnak

  • Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis.

    Angkeow P;Deshpande Ss;Qi B;Liu Yx

  • Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo

    Michitaka Ozaki;Shailesh S. Deshpande;Piamsook Angkeow;John Bellan

  • Protection from reoxygenation injury by inhibition of rac1.

    Kyung Soo Kim;Kazuyo Takeda;Rachna Sethi;John B. Pracyk

  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.

    John B. Pracyk;Koichi Tanaka;Donald D. Hegland;Kyung Soo Kim

  • Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling

    Rania Harfouche;Nelly Abdel Malak;Ralf P Brandes;Aly Karsan

  • MicroRNA miR-27b Rescues Bone Marrow–Derived Angiogenic Cell Function and Accelerates Wound Healing in Type 2 Diabetes Mellitus

    Jie Mei Wang;Jun Tao;Dan Dan Chen;Jing Jing Cai

  • [Ca2+]i Oscillation Frequency Regulates Agonist-stimulated NF-κB Transcriptional Activity

    Qinghua Hu;Shailesh Deshpande;Kaikobad Irani;Roy C. Ziegelstein

  • Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

    M Ozaki;S Haga;H Q Zhang;K Irani

Frequent Co-Authors

Toren Finkel
Toren Finkel University of Pittsburgh
Ajay Kumar
Ajay Kumar Hong Kong Polytechnic University
Charles J. Lowenstein
Charles J. Lowenstein Johns Hopkins University School of Medicine
Victor J. Ferrans
Victor J. Ferrans National Institutes of Health
Lewis C. Becker
Lewis C. Becker Johns Hopkins University School of Medicine
Qinghua Hu
Qinghua Hu Tianjin University
Kazuyo Takeda
Kazuyo Takeda US Food and Drug Administration
Jay L. Zweier
Jay L. Zweier The Ohio State University
Markus Bachschmid
Markus Bachschmid Boston University

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