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Biology and Biochemistry

D-Index
65
Citations
17424
World Ranking
9060
National Ranking
4027

Overview

Patrick J. Pagano is affiliated with the University of Pittsburgh in the United States. Their research spans medicine and biochemistry, genetics, and molecular biology, with numerous publications focusing on molecular biology, immunology, physiology, pulmonary and respiratory medicine, and cancer research.

The scientist has contributed extensively to topics such as neutrophil, myeloperoxidase and oxidative mechanisms; nitric oxide and endothelin effects; pulmonary hypertension research and treatments; redox biology and oxidative stress; hormonal regulation and hypertension; cardiovascular, neuropeptides, and oxidative stress research; and renin-angiotensin system studies.

Frequent publication venues for their work include Hypertension, Redox Biology, bioRxiv (Cold Spring Harbor Laboratory), Free Radical Biology and Medicine, and Antioxidants.

Some notable recent papers include:

  • CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis (2020, Cells)
  • NADPH oxidase 2 activity in Parkinson's disease (2022, Neurobiology of Disease)
  • Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury (2021, Journal of the American Society of Nephrology)
  • Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence (2021, Proceedings of the National Academy of Sciences)
  • NADPH oxidases: redox regulation of cell homeostasis and disease (2025, Physiological Reviews)

Patrick J. Pagano has collaborated regularly with several co-authors, including Eugenia Cifuentes-Pagano, Adam C. Straub, Christopher M. Dustin, Yao Li, and Damir Kračun.

Best Publications

  • Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

    Victoria M. Bolotina;Soheil Najibi;James J. Palacino;Patrick J. Pagano

  • Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts.

    Deborah A. Siwik;Patrick J. Pagano;Wilson S. Colucci

  • Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O2− and Systolic Blood Pressure in Mice

    F. E. Rey;M. E. Cifuentes;A. Kiarash;M. T. Quinn

  • Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.

    Rhian M. Touyz;Xin Chen;Fatiha Tabet;Guoying Yao

  • Novel Role of gp91phox-Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis

    Masuko Ushio-Fukai;Yan Tang;Tohru Fukai;Sergey I. Dikalov

  • Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

    Pagano Pj;Clark Jk;Cifuentes-Pagano Me;Clark Sm

  • Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide

    Hui Di Wang;Patrick J. Pagano;Yue Du;Antonio J. Cayatte

  • Reactive Oxygen Species Mediate Amplitude-Dependent Hypertrophic and Apoptotic Responses to Mechanical Stretch in Cardiac Myocytes

    David R. Pimentel;Jay K. Amin;Lei Xiao;Thomas Miller

  • An NADPH oxidase superoxide-generating system in the rabbit aorta

    Patrick J. Pagano;Yasushi Ito;K. Tornheim;P. M. Gallop

  • Inhibition of Copper-Zinc Superoxide Dismutase Induces Cell Growth, Hypertrophic Phenotype, and Apoptosis in Neonatal Rat Cardiac Myocytes In Vitro

    Deborah A. Siwik;John D. Tzortzis;David R. Pimental;Donny L.-F. Chang

  • Platelet-derived HMGB1 is a critical mediator of thrombosis.

    Sebastian Vogel;Sebastian Vogel;Rebecca Bodenstein;Qiwei Chen;Susanne Feil

  • Angiotensin II Induces p67phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts

    Patrick J. Pagano;Stephen J. Chanock;Deborah A. Siwik;Wilson S. Colucci

  • Hydrogen Peroxide as a Paracrine Vascular Mediator: Regulation and Signaling Leading to Dysfunction

    Noelia Ardanaz;Patrick J. Pagano

  • Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

    Imad Al Ghouleh;Nicholas K.H. Khoo;Ulla G. Knaus;Kathy K. Griendling

  • Vascular gp91(phox): beyond the endothelium.

    Patrick J. Pagano

  • The Reactive Adventitia Fibroblast Oxidase in Vascular Function

    Federico E. Rey;Patrick J. Pagano

  • Reactive Oxygen Species Mediate Alpha-adrenergic Receptor-stimulated Hypertrophy in Adult Rat Ventricular Myocytes

    Jay K Amin;Lei Xiao;Lei Xiao;David R Pimental;David R Pimental;Patrick J Pagano;Patrick J Pagano

  • NAD(P)H Oxidase Mediates Angiotensin II–Induced Vascular Macrophage Infiltration and Medial Hypertrophy

    Jianhua Liu;Fang Yang;Xiao-Ping Yang;Michelle Jankowski

  • Glycated Proteins Stimulate Reactive Oxygen Species Production in Cardiac Myocytes Involvement of Nox2 (gp91phox)-Containing NADPH Oxidase

    Min Zhang;Ay Lin Kho;Narayana Anilkumar;Rakesh Chibber

  • Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice.

    M. Eugenia Cifuentes;Federico E. Rey;Oscar A. Carretero;Patrick J. Pagano

Frequent Co-Authors

Mark T. Quinn
Mark T. Quinn Montana State University
Oscar A. Carretero
Oscar A. Carretero Henry Ford Hospital
Mauricio Rojas
Mauricio Rojas University of Pittsburgh
Richard A. Cohen
Richard A. Cohen Boston University
Wilson S. Colucci
Wilson S. Colucci Boston University
Mark T. Gladwin
Mark T. Gladwin University of Pittsburgh
Federico E. Rey
Federico E. Rey University of Wisconsin–Madison
Claudette M. St. Croix
Claudette M. St. Croix University of Pittsburgh
Rhian M. Touyz
Rhian M. Touyz McGill University Health Centre
Douglas B. Sawyer
Douglas B. Sawyer Maine Medical Center

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