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Medicine

D-Index
108
Citations
42139
World Ranking
6012
National Ranking
66

Overview

Jorma Isola is affiliated with Tampere University in Finland and has contributed extensively to the field of medicine, with a concentrated focus on gastroenterology. Their body of work encompasses research in several subfields, including gastroenterology, epidemiology, oncology, radiology, nuclear medicine and imaging, and surgery.

Their research spans key topics such as celiac disease research and management, microscopic colitis, HER2/EGFR in cancer research, monoclonal and polyclonal antibodies research, digestive system and related health, genetic factors in colorectal cancer, and Helicobacter pylori-related gastroenterology studies.

Notable recent publications include:

  • A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease (2021, New England Journal of Medicine)
  • ARX788, a novel anti-HER2 antibody-drug conjugate, shows anti-tumor effects in preclinical models of trastuzumab emtansine-resistant HER2-positive breast cancer and gastric cancer (2020, Cancer Letters)
  • Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge (2020, Cellular and Molecular Gastroenterology and Hepatology)
  • Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy (2021, Scientific Reports)
  • Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge (2022, Gastroenterology)

Frequent co-authors collaborating with Jorma Isola include Markku Mäki, Juha Taavela, Alina Popp, Heikki Joensuu, and Keijo Viiri. These collaborations highlight a network of researchers with shared interests in related medical and gastroenterological topics.

Jorma Isola's work has been published predominantly in the following venues:

  • Gastroenterology
  • Cancer Letters
  • Scientific Reports
  • The Lancet. Gastroenterology & Hepatology
  • Digestive Diseases and Sciences

Their research contributions are situated within a strong clinical and biomedical context, addressing both disease mechanisms and therapeutic approaches. The focus on celiac disease and cancer-related antibody research ties together immune-mediated and oncological pathways. The use of transcriptomic analyses and advanced imaging reflects an integration of molecular and clinical methodologies to understand disease at multiple levels.

Best Publications

  • In vivo amplification of the androgen receptor gene and progression of human prostate cancer.

    Tapio Visakorpi;Eija Hyytinen;Pasi Koivisto;Minna Tanner

  • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer.

    Heikki Joensuu;Pirkko-Liisa Kellokumpu-Lehtinen;Petri Bono;Tuomo Alanko

  • Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors.

    Olli‐P ‐P Kallioniemi;Anne Kallioniemi;Jim Piper;Jorma Isola

  • Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.

    Ari Ristimäki;Anna Sivula;Johan Lundin;Mikael Lundin

  • Androgen Receptor Gene Amplification: A Possible Molecular Mechanism for Androgen Deprivation Therapy Failure in Prostate Cancer

    Pasi Koivisto;Juha Kononen;Christian Palmberg;Teuvo Tammela

  • Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab

    M. Tanner;M. Hollmén;T. T. Junttila;A. I. Kapanen

  • Inherited susceptibility to uterine leiomyomas and renal cell cancer

    Virpi Launonen;Outi Vierimaa;Maija Ht Kiuru;Jorma Isola

  • Decreased Accessibility and Lack of Activation of ErbB2 in JIMT-1, a Herceptin-Resistant, MUC4-Expressing Breast Cancer Cell Line

    Peter Nagy;Elza Friedländer;Minna Tanner;Anita I. Kapanen

  • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

    Lao H. Saal;Peter Johansson;Karolina Holm;Sofia K. Gruvberger-Saal

  • Genetic Changes in Primary and Recurrent Prostate Cancer by Comparative Genomic Hybridization

    Tapio Visakorpi;Anne H. Kallioniemi;Ann-Christine Syvänen;Eija R. Hyytinen

  • ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67

    Vilppu J Tuominen;Sanna Ruotoistenmäki;Arttu Viitanen;Mervi Jumppanen

  • Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial

    Heikki Joensuu;Petri Bono;Vesa Kataja;Tuomo Alanko

  • Trastuzumab emtansine: mechanisms of action and drug resistance

    Mark Barok;Heikki Joensuu;Jorma Isola

  • Molecular cytogenetics of primary breast cancer by CGH.

    Mika Tirkkonen;Minna Tanner;Ritva Karhu;Anne Kallioniemi

  • Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer

    Tero A.H. Järvinen;Minna Tanner;Virpi Rantanen;Maarit Bärlund

  • Genetic Heterogeneity and Clonal Evolution Underlying Development of Asynchronous Metastasis in Human Breast Cancer

    Tuula Kuukasjärvi;Ritva Karhu;Minna Tanner;Marketta Kähkönen

  • Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer.

    Olli-P. Kallioniemi;Kaija Holli;Tapio Visakorpi;Timo Koivula

  • Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

    Jorma Isola;Tapio Visakorpi;Kaija Holli;Olli-P. Kallioniemi

  • Chromogenic in Situ Hybridization: A Practical Alternative for Fluorescence in Situ Hybridization to Detect HER-2/neu Oncogene Amplification in Archival Breast Cancer Samples

    Minna Tanner;David Gancberg;Angelo Di Leo;Denis Larsimont

  • Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy.

    T Kuukasjärvi;J Kononen;H Helin;K Holli

Frequent Co-Authors

Minna Tanner
Minna Tanner Tampere University
Heikki Joensuu
Heikki Joensuu University of Helsinki
Tapio Visakorpi
Tapio Visakorpi Tampere University
Åke Borg
Åke Borg Lund University
Vesa Kataja
Vesa Kataja University of Eastern Finland
Ritva Karhu
Ritva Karhu Tampere University
Teuvo L.J. Tammela
Teuvo L.J. Tammela Tampere University
Anne Kallioniemi
Anne Kallioniemi Tampere University
Klaus Elenius
Klaus Elenius University of Turku
Pentti Tuohimaa
Pentti Tuohimaa Tampere University

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