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Immunology

D-Index
63
Citations
24428
World Ranking
2976
National Ranking
1400

Overview

Jonathon D. Sedgwick is affiliated with Eli Lilly in the United States, focusing primarily on medical research within oncology and related subfields.

Their work spans several areas of study, including:

  • Oncology
  • Cancer Research
  • Pathology and Forensic Medicine
  • Neurology
  • Immunology

Main research topics encompass:

  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Colorectal Cancer Treatments and Studies
  • CAR-T cell therapy research
  • Neuroblastoma Research and Treatments
  • Interferon and immune responses

The researcher has contributed to publications in several venues, notably:

  • JCO Precision Oncology
  • OncoImmunology
  • Cancer Research

Recent papers include:

  • Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases (2021, JCO Precision Oncology)
  • Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses (2022, OncoImmunology)
  • Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist (2020, Cancer Research)

Frequent collaborators in their research include:

  • Otmar Schaaf
  • Norbert Kraut
  • Fotios Loupakis
  • Shruti Sharma
  • Madiha Derouazi

Best Publications

  • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

    Daniel J. Cua;Jonathan Sherlock;Yi Chen;Craig A. Murphy

  • Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

    Craig A. Murphy;Claire L. Langrish;Yi Yi Chen;Wendy M Blumenschein

  • A chemokine-driven positive feedback loop organizes lymphoid follicles

    K M Ansel;V N Ngo;P L Hyman;S A Luther

  • Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

    Robert M. Hoek;Sigrid R. Ruuls;Craig A. Murphy;Gavin J. Wright

  • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

    J D Sedgwick;S Schwender;H Imrich;R Dörries

  • CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.

    Bernhard Homey;Harri Alenius;Anja Müller;Hortensia Soto

  • Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

    Unknown

  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.

    Vu N. Ngo;Heinrich Korner;Michael D. Gunn;Kerstin N. Schmidt

  • Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.

    G J Wright;M J Puklavec;A C Willis;R M Hoek

  • A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

    Robert J Snelgrove;John Goulding;Arnaud M Didierlaurent;Daphne Lyonga

  • Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.

    Gavin J. Wright;Holly Cherwinski;Mildred Foster-Cuevas;Gary Brooke

  • Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

    Susumu Nakae;Hajime Suto;Hajime Suto;Motoyasu Iikura;Maki Kakurai

  • The IL-23/Th17 axis : therapeutic targets for autoimmune inflammation

    Kristine Kikly;Ling Liu;Songqing Na;Jonathon D Sedgwick

  • STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

    Matthias Ernst;Meri Najdovska;Dianne Grail;Therese Lundgren-May

  • Mast Cell-Associated TNF Promotes Dendritic Cell Migration

    Hajime Suto;Susumu Nakae;Maki Kakurai;Jonathon D. Sedgwick

  • DAP12-Deficient Mice Fail to Develop Autoimmunity Due to Impaired Antigen Priming

    Alexander B.H. Bakker;Robert M. Hoek;Adelheid Cerwenka;Bianca Blom

  • Mast cells enhance T cell activation: Importance of mast cell-derived TNF

    Susumu Nakae;Hajime Suto;Maki Kakurai;Jonathon D. Sedgwick

  • Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.

    Heinrich Körner;Matthew Cook;D. Sean Riminton;Frances A. Lemckert

  • Tumor necrosis factor: a master-regulator of leukocyte movement.

    Jonathon D Sedgwick;D.Sean Riminton;Jason G Cyster;Heinrich Körner

  • Molecular Mechanisms of CD200 Inhibition of Mast Cell Activation

    Shuli Zhang;Holly Cherwinski;Jonathon D. Sedgwick;Joseph H. Phillips

  • Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

    Sigrid R Ruuls;Robert M Hoek;Vu N Ngo;Tom McNeil

  • Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

    H Körner;D S Riminton;D H Strickland;F A Lemckert

Frequent Co-Authors

Heinrich Körner
Heinrich Körner University of Tasmania
Dirk Schlüter
Dirk Schlüter Otto-von-Guericke University Magdeburg
Sergio A. Lira
Sergio A. Lira Icahn School of Medicine at Mount Sinai
Joseph H. Phillips
Joseph H. Phillips MSD (United States)
Jason G. Cyster
Jason G. Cyster University of California, San Francisco
Stephen J. Galli
Stephen J. Galli Stanford University
Gavin J. Wright
Gavin J. Wright Wellcome Sanger Institute
Maria C. Jenmalm
Maria C. Jenmalm Linköping University
Mindy Tsai
Mindy Tsai Stanford University
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute

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