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D-Index
103
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44109
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7296
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Overview

John Nemunaitis is affiliated with Gradalis in the United States and has contributed extensively to medical research, primarily focusing on oncology and related biomedical fields. Their work spans from clinical trials to biomarker and immunotherapy research, with a broad interdisciplinary approach crossing medicine, biochemistry, genetics, and molecular biology.

The scientist has published in prominent venues, with frequent publications in the following journals:

  • Journal of Clinical Oncology
  • Future Oncology
  • Gynecologic Oncology
  • Cancer Gene Therapy
  • Oncology Reviews

Nemunaitis' primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Oncology, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Genetics.

The main topics in Nemunaitis' research portfolio cover a diverse set of areas related to cancer and immune therapies:

  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Cancer Research and Treatments
  • PARP inhibition in cancer therapy
  • Ovarian cancer diagnosis and treatment
  • Cancer Genomics and Diagnostics

Notable recent papers by Nemunaitis include:

  • "Ovarian Cancer Immunotherapy and Personalized Medicine" (2021), published in International Journal of Molecular Sciences
  • "TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials" (2020), in Cancer Gene Therapy
  • "First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors" (2020), published in Journal of Clinical Oncology
  • "Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer" (2023), in Journal of Clinical Oncology
  • "The Abscopal Effect of Radiation Therapy" (2021), published in Future Oncology

Frequent collaborators in Nemunaitis' research include Laura Stanbery, Ernest Bognar, Rodney P. Rocconi, Adam Walter, and Luisa Manning, reflecting collaborative efforts across clinical and scientific disciplines. The partnership with these colleagues has resulted in numerous co-authored studies enhancing the understanding of oncology and immunotherapy.

Best Publications

  • Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

    David H. Johnson;Louis Fehrenbacher;William F. Novotny;Roy S. Herbst

  • Placebo-Controlled Phase III Trial of Immunologic Therapy with Sipuleucel-T (APC8015) in Patients with Metastatic, Asymptomatic Hormone Refractory Prostate Cancer

    Eric J. Small;Paul F. Schellhammer;Celestia S. Higano;Charles H. Redfern

  • Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

    R H Collins;O Shpilberg;W R Drobyski;D L Porter

  • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

    Fadlo R. Khuri;John Nemunaitis;Ian Ganly;James Arseneau

  • Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

    Manuel Hidalgo;Lillian L. Siu;John Nemunaitis;Jinee Rizzo

  • Phase III Trial of Gemcitabine Plus Cisplatin Versus Cisplatin Alone in Patients With Locally Advanced or Metastatic Non–Small-Cell Lung Cancer

    Alan B. Sandler;J. Nemunaitis;C. Denham;J. Von Pawel

  • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with Sipuleucel-T in advanced prostate cancer

    Celestia S. Higano;Paul F. Schellhammer;Eric J. Small;Patrick A. Burch

  • siRNA vs. shRNA: similarities and differences.

    Donald D. Rao;John S. Vorhies;Neil Senzer;John Nemunaitis

  • Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

    Neil N. Senzer;Howard L. Kaufman;Thomas Amatruda;Mike Nemunaitis

  • Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer

    Stephen G. Swisher;Jack A. Roth;John Nemunaitis;David D. Lawrence

  • Phase II Trial of Intratumoral Administration of ONYX-015, a Replication-Selective Adenovirus, in Patients With Refractory Head and Neck Cancer

    J. Nemunaitis;F. Khuri;I. Ganly;J. Arseneau

  • Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer

    John Nemunaitis;John Nemunaitis;John Nemunaitis;Susan N. Rabinowe;Jack W. Singer;Jack W. Singer;Jack W. Singer;Philip J. Bierman

  • Selective Replication and Oncolysis in p53 Mutant Tumors with ONYX-015, an E1B-55kD Gene-deleted Adenovirus, in Patients with Advanced Head and Neck Cancer: A Phase II Trial

    John Nemunaitis;Ian Ganly;Fadlo Khuri;James Arseneau

  • Adenovirus-Mediated p53 Gene Transfer in Sequence With Cisplatin to Tumors of Patients With Non–Small-Cell Lung Cancer

    J. Nemunaitis;S.G. Swisher;T. Timmons;D. Connors

  • AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

    David Sanghyun Hong;Razelle Kurzrock;Youngsoo Kim;Richard Woessner

  • Allogeneic Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study of Safety, Feasibility, and Immune Activation

    Dan Laheru;Eric Lutz;James Burke;Barbara Biedrzycki

  • Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non–Small-Cell Lung Cancer

    John Nemunaitis;Robert O. Dillman;Paul O. Schwarzenberger;Neil Senzer

  • Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients.

    John Nemunaitis;Casey Cunningham;Neil Senzer;Joseph Kuhn

  • Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

    J. Nemunaitis;C. Cunningham;A. Buchanan;A. Blackburn

  • MicroRNA profile analysis of human prostate cancers

    A W Tong;P Fulgham;C Jay;P Chen

Frequent Co-Authors

Neil Senzer
Neil Senzer Gradalis (United States)
Howard L. Kaufman
Howard L. Kaufman Harvard University
Johanna C. Bendell
Johanna C. Bendell Sarah Cannon Research Institute
Jack W. Singer
Jack W. Singer University of Washington
David S. Hong
David S. Hong The University of Texas MD Anderson Cancer Center
Razelle Kurzrock
Razelle Kurzrock Medical College of Wisconsin
Sunil Chada
Sunil Chada The University of Texas MD Anderson Cancer Center
Kunle Odunsi
Kunle Odunsi Roswell Park Cancer Institute
Robert L. Coleman
Robert L. Coleman The University of Texas MD Anderson Cancer Center
Jack A. Roth
Jack A. Roth The University of Texas MD Anderson Cancer Center

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