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Jean-Philippe Deslys

Jean-Philippe Deslys

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
9588
World Ranking
15716
National Ranking
638

Overview

Jean-Philippe Deslys is affiliated with the University of Paris-Saclay in France and specializes primarily in Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Molecular Biology, Neurology, Biophysics, Physiology, and Developmental Neuroscience. The work covers key topics such as Prion Diseases and Protein Misfolding, Neurological diseases and metabolism, Pluripotent Stem Cells Research, Single-cell and spatial transcriptomics, Cell Image Analysis Techniques, Alzheimer's disease research and treatments, and CRISPR and Genetic Engineering.

The scientist's publication record includes notable papers with a range of recent contributions as listed below:

  • Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease (2020), published in Frontiers in Cellular Neuroscience
  • Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients (2021), published in Acta Neuropathologica Communications
  • Three-dimensional molecular cartography of human cerebral organoids revealed by double-barcoded spatial transcriptomics (2023), published in Cell Reports Methods
  • Development and Optimization of a Lactate Dehydrogenase Assay Adapted to 3D Cell Cultures (2024), published in Organoids
  • Non-human primates in prion diseases (2022), published in Cell and Tissue Research

Jean-Philippe Deslys frequently collaborates with several researchers including F Yates, Lucie Madrange, Emmanuel Comoy, Héloïse Castiglione, and Pierre-Antoine Vigneron.

Their research has appeared in journals such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Cellular Neuroscience, Organoids, Acta Neuropathologica Communications, and Cell Reports Methods. This publication diversity reflects a broad interdisciplinary approach combining molecular techniques and neurological investigations.

Best Publications

  • Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein

    Corinne I. Lasmézas;Jean-Philippe Deslys;Olivier Robain;Alexandre Jaegly

  • The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein

    Sabine Gauczynski;Jean‐Michel Peyrin;Stéphane Haïk;Christoph Leucht

  • BSE transmission to macaques

    C I Lasmézas;J P Deslys;R Demaimay;K T Adjou

  • Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor

    Christoph Hundt;Jean‐Michel Peyrin;Stéphane Haïk;Sabine Gauczynski

  • Novel methods for disinfection of prion-contaminated medical devices

    Guillaume Fichet;Emmanuel Comoy;Christelle Duval;Kathleen Antloga

  • BSE agent signatures in a goat

    Marc Eloit;Karim Adjou;Muriel Coulpier;Jean Jacques Fontaine

  • Evaluation of Quinacrine Treatment for Prion Diseases

    A. Barret;F. Tagliavini;G. Forloni;C. Bate

  • Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

    Corinne Ida Lasmézas;Jean-Guy Fournier;Virginie Nouvel;Hermann Boe

  • Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents.

    Thomas Maignien;Corinne Ida Lasmé zas;Vincent Beringue;Dominique Dormont

  • Gene Expression in Scrapie CLONING OF A NEW SCRAPIE-RESPONSIVE GENE AND THE IDENTIFICATION OF INCREASED LEVELS OF SEVEN OTHER mRNA TRANSCRIPTS

    Françoise Dandoy-Dron;Frédéric Guillo;Louisa Benboudjema;Jean-Philippe Deslys

  • Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

    Vincent Beringue;Marina Demoy;Corinne I. Lasmézas;Bruno Gouritin

  • Immune system-dependent and -independent replication of the scrapie agent.

    C I Lasmézas;J Y Cesbron;J P Deslys;R Demaimay

  • Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection

    Herzog C;Salès N;Etchegaray N;Charbonnier A

  • PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases

    Pilar Calvo;Bruno Gouritin;Irène Brigger;Corinne Lasmezas

  • Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate.

    Emmanuel E. Comoy;Cristina Casalone;Nathalie Lescoutra-Etchegaray;Gianluigi Zanusso

  • Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.

    Jean Michel Peyrin;Corinne Ida Lasmézas;Stéphane Haïk;Fabrizio Tagliavini

  • Similar genetic susceptibility in iatrogenic and sporadic Creutzfeldt-Jakob disease

    Jean-Philippe Deslys;Dominique Marcé;Dominique Dormont

  • New insight into abnormal prion protein using monoclonal antibodies.

    Séverine Demart;Jean-Guy Fournier;Christophe Creminon;Yveline Frobert

  • Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy.

    Corinne Ida Lasmézas;Jean-Philippe Deslys;Rémi Demaimay;Karim T. Adjou

  • Risk of oral infection with bovine spongiform encephalopathy agent in primates

    Corinne Ida Lasmézas;Emmanuel Comoy;Stephen Hawkins;Christian Herzog

Frequent Co-Authors

Dominique Dormont
Dominique Dormont French Alternative Energies and Atomic Energy Commission (CEA)
Corinne Ida Lasmézas
Corinne Ida Lasmézas Scripps Research Institute
Jean-Jacques Hauw
Jean-Jacques Hauw Grenoble Alpes University
Paul Brown
Paul Brown National Institutes of Health
Jacques Grassi
Jacques Grassi French Alternative Energies and Atomic Energy Commission (CEA)
James W. Ironside
James W. Ironside University of Edinburgh
Fabrizio Tagliavini
Fabrizio Tagliavini Istituto Neurologico Carlo Besta
Vincent Calvez
Vincent Calvez Centre national de la recherche scientifique, CNRS
Patrick Couvreur
Patrick Couvreur University of Paris-Saclay

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