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Chemistry

D-Index
43
Citations
6250
World Ranking
17283
National Ranking
2611

Overview

Guoqiang Dong is affiliated with the Second Military Medical University in China and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans a total of 93 publications in these main areas, with a significant focus on molecular biology and oncology.

The scientist's work predominantly centers on the study of protein degradation and inhibitors, with 68 publications addressing this topic. Other key research areas include peptidase inhibition and analysis, ubiquitin and proteasome pathways, histone deacetylase inhibitors research, multiple myeloma research and treatments, quinazolinone synthesis and applications, and cancer therapeutics and mechanisms.

Frequent coauthors in Guoqiang Dong's collaborations are:

  • Chunquan Sheng
  • Shipeng He
  • Shanchao Wu
  • Junfei Cheng
  • Yuxin Fang

Guoqiang Dong has published multiple papers in reputable journals, demonstrating active engagement in medicinal chemistry and chemical biology fields. Key recent papers include:

  • "Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery," 2021, Journal of Medicinal Chemistry
  • "Aptamer-PROTAC Conjugates (APCs) for Tumor-Specific Targeting in Breast Cancer," 2021, Angewandte Chemie International Edition
  • "Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer," 2020, Angewandte Chemie International Edition
  • "Fulvic acid ameliorates drought stress-induced damage in tea plants by regulating the ascorbate metabolism and flavonoids biosynthesis," 2020, BMC Genomics
  • "Targeting necroptosis in anticancer therapy: mechanisms and modulators," 2020, Acta Pharmaceutica Sinica B

Publication venues frequently chosen by Guoqiang Dong include:

  • Journal of Medicinal Chemistry
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Acta Pharmaceutica Sinica B
  • European Journal of Medicinal Chemistry

Their research also extends to related subfields such as organic chemistry, hematology, and biomedical engineering, with publications covering molecular biology, oncology, organic chemistry, hematology, and biomedical engineering topics. This multidisciplinary approach is reflected in the diversity of research topics and publication venues.

Best Publications

  • Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery.

    Guoqiang Dong;Yu Ding;Shipeng He;Chunquan Sheng

  • Aptamer-PROTAC Conjugates (APCs) for Tumor-specific Targeting in Breast Cancer

    Shipeng He;Fei Gao;Junhui Ma;Haoqian Ma

  • Structural Simplification of Natural Products

    Shengzheng Wang;Shengzheng Wang;Guoqiang Dong;Chunquan Sheng

  • New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.

    Guoqiang Dong;Shengzheng Wang;Zhenyuan Miao;Jianzhong Yao

  • Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.

    Shengzheng Wang;Shengzheng Wang;Kun Fang;Guoqiang Dong;Shuqiang Chen

  • State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

    Chunquan Sheng;Guoqiang Dong;Zhenyuan Miao;Wannian Zhang

  • Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents.

    Guoqiang Dong;Chunquan Sheng;Shengzheng Wang;Zhenyuan Miao

  • Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.

    Chunlin Zhuang;Zhenyuan Miao;Lingjian Zhu;Guoqiang Dong

  • Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

    Chunquan Sheng;Zhenyuan Miao;Haitao Ji;Jianzhong Yao

  • Emerging New Targets for the Treatment of Resistant Fungal Infections.

    Na Liu;Jie Tu;Guoqiang Dong;Yan Wang

  • Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

    Shipeng He;Shipeng He;Shipeng He;Guoqiang Dong;Yu Li;Shanchao Wu

  • Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections

    Yahui Huang;Guoqiang Dong;Huanqiu Li;Na Liu

  • Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

    Guoqiang Dong;Wei Chen;Xia Wang;Xinglin Yang

  • Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3'-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors.

    Shengzheng Wang;Shengzheng Wang;Yan Jiang;Shanchao Wu;Guoqiang Dong

  • Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.

    Zhigan Jiang;Julin Gu;Chen Wang;Shengzheng Wang

  • New azoles with potent antifungal activity: design, synthesis and molecular docking.

    Xiaoying Che;Chunquan Sheng;Wenya Wang;Yongbing Cao

  • Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

    Yongqiang Zhang;Shanchao Wu;Shengzheng Wang;Kun Fang;Kun Fang

  • Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents.

    Shipeng He;Guoqiang Dong;Shanchao Wu;Kun Fang

  • Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer.

    Shipeng He;Junhui Ma;Yuxin Fang;Ying Liu

  • Structural simplification: an efficient strategy in lead optimization.

    Shengzheng Wang;Shengzheng Wang;Guoqiang Dong;Chunquan Sheng

  • Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement.

    Zhigan Jiang;Yan Wang;Wenya Wang;Shengzheng Wang

  • Design and synthesis of cyclopropylamide analogues of combretastatin-A4 as novel microtubule-stabilizing agents.

    Huan Chen;Yongmei Li;Chunquan Sheng;Zhiliang Lv

Frequent Co-Authors

Wei Wang
Wei Wang East China University of Science and Technology
Hengming Ke
Hengming Ke University of North Carolina at Chapel Hill
Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
Yingying Le
Yingying Le Chinese Academy of Sciences
Hao Li
Hao Li Zhejiang University

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